Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jacob C. Schwartz"'
Autor:
Simona Krasnopolsky, Lital Marom, Rachel A. Victor, Alona Kuzmina, Jacob C. Schwartz, Koh Fujinaga, Ran Taube
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-19 (2019)
Abstract Background The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transc
Externí odkaz:
https://doaj.org/article/713a51bffa35458d803d3907929cb896
Autor:
Alyssa N. Coyne, Ileana Lorenzini, Ching-Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Externí odkaz:
https://doaj.org/article/864d5b20cac14a2c8ea1e98ca71ebe07
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 918-925 (2013)
The abundant nuclear RNA binding protein FUS binds the C-terminal domain (CTD) of RNA polymerase II in an RNA-dependent manner, affecting Ser2 phosphorylation and transcription. Here, we examine the mechanism of this process and find that RNA binding
Externí odkaz:
https://doaj.org/article/5b41648a73e3435487fb01d3ba255caa
Autor:
Alona Kuzmina, Lopamudra Sadhu, Md Hasanuzzaman, Koh Fujinaga, Jacob C Schwartz, Oliver T Fackler, Ran Taube
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012172 (2024)
The implementation of antiretroviral therapy (ART) has effectively restricted the transmission of Human Immunodeficiency Virus (HIV) and improved overall clinical outcomes. However, a complete cure for HIV remains out of reach, as the virus persists
Externí odkaz:
https://doaj.org/article/26e3e77428d6413ba9341675a8907c27
Autor:
Valery F. Thompson, Daniel R. Wieland, Vivian Mendoza-Leon, Helen I. Janis, Michelle A. Lay, Lucas M. Harrell, Jacob C. Schwartz
The protein FUS (FUSed in sarcoma) is a metazoan RNA-binding protein that influences RNA production by all three nuclear polymerases. FUS also binds nascent transcripts, RNA processing factors, RNA polymerases, and transcription machinery. We explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27fbbd2ddd3ca5dba2295630d8de82e2
https://doi.org/10.1101/2022.08.11.503633
https://doi.org/10.1101/2022.08.11.503633
Autor:
Valery F. Thompson, Jacob C. Schwartz, Michelle A Lay, Nasiha S. Ahmed, Lucas M. Harrell, Daniel R. Wieland
Publikováno v:
RNA
Ewing sarcoma is driven by fusion proteins containing a low complexity (LC) domain that is intrinsically disordered and a powerful transcriptional regulator. The most common fusion protein found in Ewing sarcoma, EWS-FLI1, takes its LC domain from th
Autor:
Natalie K. Barker, Paul R. Langlais, Jacob C. Schwartz, Mahta Moinpour, Lindsay E. Guzman, John C. Jewett
Publikováno v:
Protein Sci
Chemical modification of proteins has been crucial in engineering protein‐based therapies, targeted biopharmaceutics, molecular probes, and biomaterials. Here, we explore the use of a conjugation‐based approach to sense alternative conformational
Autor:
Tetsuya Kawaguchi, William M. Old, Christopher C. Ebmeier, Andres A. Morera, Mahta Moinpour, Jacob C. Schwartz, Matthew Rollins
Publikováno v:
Journal of Proteome Research
The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly all ALS patients. Both the natural function and contribution to pathology
Autor:
Anthony E. Kline, Jeffrey P. Cheng, Julia Kofler, Udai Bhan Pandey, Jacob C. Schwartz, Amanda M. Gleixner, Thor D. Stein, Eric N. Anderson, William M. Old, Nandini Ramesh, Andres A. Morera, Christopher C. Ebmeier, Jonathan D. Cherry, Sukhleen Kour, Christopher J. Donnelly
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although def
Autor:
Christopher J. Donnelly, Christopher C. Ebmeier, Andres A. Morera, Amanda M. Gleixner, Eric N. Anderson, Thor D. Stein, Jeffrey P. Cheng, Jonathan D. Cherry, Udai Bhan Pandey, Julia Kofler, Anthony E. Kline, Nandini Ramesh, William M. Old, Sukhleen Kour, Jacob C. Schwartz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a1fbe471be4ed942dccbb3d95f4723f
https://doi.org/10.7554/elife.67587.sa2
https://doi.org/10.7554/elife.67587.sa2