Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacob C. Kimmel"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005927 (2018)
Cell populations display heterogeneous and dynamic phenotypic states at multiple scales. Similar to molecular features commonly used to explore cell heterogeneity, cell behavior is a rich phenotypic space that may allow for identification of relevant
Externí odkaz:
https://doaj.org/article/7155a5a63bc740189f098f7284f912f6
Autor:
Jacob C. Kimmel, Rochelle Buffenstein, Marian M. Deuker, Kaitlyn N. Lewis, Maria Ingaramo, Jeff Settleman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The naked mole-rat is a subterranean rodent, approximately the size of a mouse, renowned for its exceptional longevity (>30 years) and remarkable resistance to cancer. To explore putative mechanisms underlying the cancer resistance of the naked mole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebeb25e85871e72585cc8db5ae73a40
http://link.springer.com/article/10.1038/s41598-020-64009-0
http://link.springer.com/article/10.1038/s41598-020-64009-0
Autor:
Antoine E, Roux, Chunlian, Zhang, Jonathan, Paw, José, Zavala-Solorio, Evangelia, Malahias, Twaritha, Vijay, Ganesh, Kolumam, Cynthia, Kenyon, Jacob C, Kimmel
Publikováno v:
Cell Systems. 13:574-587.e11
Partial pluripotent reprogramming can reverse features of aging in mammalian cells, but the impact on somatic identity and the necessity of individual reprogramming factors remain unknown. Here, we used single-cell genomics to map the identity trajec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55746f560ae2fc2b0b3975296a078911
https://doi.org/10.1016/j.cels.2022.05.002
https://doi.org/10.1016/j.cels.2022.05.002
Autor:
Twaritha Vijay, Jacob C. Kimmel, José-Zavalara Solorio, Ganesh Kolumam, Chunlian Zhang, Antoine E. Roux, Cynthia Kenyon, Jonathan S. Paw
Transient induction of pluripotent reprogramming factors has been reported to reverse some features of aging in mammalian cells and tissues. However, the impact of transient reprogramming on somatic cell identity programs and the necessity of individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d890b909f187223879079de81784a6
https://doi.org/10.1101/2021.05.21.444556
https://doi.org/10.1101/2021.05.21.444556
Autor:
Jacob C. Kimmel, David R. Kelley
Publikováno v:
Genome Res
Annotating cell identities is a common bottleneck in the analysis of single-cell genomics experiments. Here, we present scNym, a semisupervised, adversarial neural network that learns to transfer cell identity annotations from one experiment to anoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3449858b850f6b925ed1ac8805c27b
https://pubmed.ncbi.nlm.nih.gov/33627475
https://pubmed.ncbi.nlm.nih.gov/33627475
Skeletal muscle experiences a decline in lean mass and regenerative potential with age, in part due to intrinsic changes in progenitor cells. However, it remains unclear if age-related changes in progenitors persist across a differentiation trajector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f7794057c6933d4feea13ff7274fc9
https://doi.org/10.1101/2020.03.05.979112
https://doi.org/10.1101/2020.03.05.979112
Publikováno v:
Cell reports. 35(4)
Summary Skeletal muscle experiences a decline in lean mass and regenerative potential with age, in part due to intrinsic changes in progenitor cells. However, it remains unclear how age-related changes in progenitors manifest across a differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84282228734f87424af1fe8ea7f2c7f
https://pubmed.ncbi.nlm.nih.gov/33910007
https://pubmed.ncbi.nlm.nih.gov/33910007
Autor:
Jacob C. Kimmel
Single cell RNA sequencing (scRNA-seq) enables transcriptional profiling at the resolution of individual cells. These experiments measure features at the level of transcripts, but biological processes of interest often involve the complex coordinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57dca9819b65bf6b6a9332e6802bc96
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation that is required for regeneration, but it remains unknown if the trajectory and dynamics of activation change with age. Here, we use time-lapse imaging and single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241dfce7752a941e227f7976c63922bb
https://doi.org/10.1242/dev.183855
https://doi.org/10.1242/dev.183855