Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jacob C. Harrison"'
Autor:
Tomonari Kaji, Sarah J. Longo, A.R. Palmer, Sheila N. Patek, G.M. Farley, Justin F. Jorge, William J. Ray, Jacob C. Harrison
Publikováno v:
Current biology : CB. 31(3)
Surprisingly, the fastest motions are not produced by large animals or robots. Rather, small organisms or structures, including cnidarian stinging cells, fungal shooting spores, and mandible strikes of ants, termites, and spiders, hold the world acce
Publikováno v:
Applied and Environmental Microbiology, 77 (3), 2011
Malic enzyme catalyzes the reversible oxidative decarboxylation of malate to pyruvate and CO 2 . The Saccharomyces cerevisiae MAE1 gene encodes a mitochondrial malic enzyme whose proposed physiological roles are related to the oxidative, malate-decar
Publikováno v:
Applied and Environmental Microbiology, 76 (16), 2010
Pyruvate carboxylase is the sole anaplerotic enzyme in glucose-grown cultures of wild-type Saccharomyces cerevisiae . Pyruvate carboxylase-negative (Pyc − ) S. cerevisiae strains cannot grow on glucose unless media are supplemented with C 4 compoun
Publikováno v:
Current Biology. 20(4):328-332
Eukaryotic cells employ a suite of replication and mitotic checkpoints to ensure the accurate transmission of their DNA. In budding yeast, both the DNA damage checkpoint and the spindle assembly checkpoint (SAC) block cells prior to anaphase [1-5]. T
Autor:
Hee-Sook Kim, John H.J. Petrini, Sangeetha Vijayakumar, James E. Haber, Jacob C. Harrison, Mike Reger, Clifford F. Weil
Publikováno v:
Genetics. 178:711-723
The Mre11 complex functions in double-strand break (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways. Sae2 deficiency has opposing effects on the Mre11 complex. On one hand, it appears to impair Mre11 nuclease function in DNA re
Autor:
James E. Haber, Jacob C. Harrison
Publikováno v:
Annual Review of Genetics. 40:209-235
In response to even a single chromosomal double-strand DNA break, cells enact the DNA damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to repair damaged chromosomes before entering mitosis. This mechanism hel
Autor:
Jung-Ae Kim, Judy Lieberman, Stephen Buratowski, Jeffrey Fillingham, Nevan J. Krogan, Michael Downey, Sarah Galicia, Xuetong Shen, Jack Greenblatt, James E. Haber, Michael-Christopher Keogh, Daniel Durocher, Andrew Emili, Jacob C. Harrison, Dipanjan Chowdhury, Nira Datta, Megumi Onishi
Publikováno v:
Nature. 439:497-501
One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif to create gammaH2AX-containing nucleosomes. Budding-yeast histone H2A is phosphorylated in
Autor:
Trevin R. Zyla, John N. McMillan, Daniel J. Lew, Aron R. Marquitz, Jacob C. Harrison, Indrani Bose
Publikováno v:
The EMBO Journal. 21:4012-4025
The Saccharomyces cerevisiae morphogenesis checkpoint delays mitosis in response to insults that impair actin organization and/or bud formation. The delay is due to accumulation of the inhibitory kinase Swe1p, which phosphorylates the cyclin-dependen
Publikováno v:
Biology of Reproduction. 63:1706-1712
At fertilization in most animals, cortical granules of the egg or oocyte secrete their contents, whose function it is to modify the extracellular matrix. This modified matrix then participates in the block to polyspermy and protection for early embry
Autor:
James E. Haber, Vikram Ranade, Satoshi Yoshida, Ayelet A Eden, Farokh Dotiwala, Vinay V. Eapen, Jacob C. Harrison
Publikováno v:
The FASEB Journal. 27