Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jacob Bode"'
Autor:
J. S. Daniels, Heather A. Bimonte-Nelson, Nellie Byun, Ryan D. Morrison, Colleen M. Niswender, A. G. Walker, P.J. Conn, Gregory J. Digby, Carrie K. Jones, M. F. Olive, Hykeyung P. Cho, Sarah E. Mennenga, Craig W. Lindsley, N. E. Nemirovsky, K. Italiano, Michael Bubser, Evan P. Lebois, M. J. Noetzel, Jacob Bode, Bryan W. Camp, Douglas J. Sheffler, Zixiu Xiang, A. A. Davis, T. J. Utley
Publikováno v:
Journal of Neuroscience. 32:8532-8544
M(1) muscarinic acetylcholine receptors (mAChRs) represent a viable target for treatment of multiple disorders of the central nervous system (CNS) including Alzheimer's disease and schizophrenia. The recent discovery of highly selective allosteric ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81b4ac7dfac148f75ed34db89a39d5d
https://doi.org/10.1523/jneurosci.0337-12.2012
https://doi.org/10.1523/jneurosci.0337-12.2012
Autor:
Mark L. Wolfe, Jacob Bode, H. David Fischer, Merrill S. Babcock, W. Rodney Mathews, Gurnam S. Gill, Robert L. Garlick, Eric T. Baldwin, Shenping Liu, Jeanne S. Chang, Bruce N. Rogers, Brandon J. Margolis, Eric T. Lund, Vince Groppi
Publikováno v:
Protein Expression and Purification. 79:102-110
Nicotinic acetylcholine receptors (nAChRs) form ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are members of a large family of pentameric ion channels that are of active medical interest. An expression s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5ad9a679c3ecb882f12cae4e556bb3
https://doi.org/10.1016/j.pep.2011.05.019
https://doi.org/10.1016/j.pep.2011.05.019
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2011)
Frontiers in Pharmacology
Frontiers in Pharmacology
Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a44c4e843dd97fcca9021232782383a
Autor:
Colleen M. Niswender, Jacob Bode, Corey R. Hopkins, Satyawan Jadhav, Ryan D. Morrison, Nathalie Turle-Lorenzo, J. Scott Daniels, Kimberly Italiano, P. Jeffrey Conn, Carrie K. Jones, Marianne Amalric, Anna L. Blobaum, Thomas M. Bridges, Darren W. Engers, Jonathan W. Dickerson, Michael Bubser, Craig W. Lindsley, Analisa D. Thompson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2012, 340 (2), pp.404-421. ⟨10.1124/jpet.111.187443⟩
Journal of Pharmacology and Experimental Therapeutics, 2012, 340 (2), pp.404-421. ⟨10.1124/jpet.111.187443⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2012, 340 (2), pp.404-421. ⟨10.1124/jpet.111.187443⟩
Journal of Pharmacology and Experimental Therapeutics, 2012, 340 (2), pp.404-421. ⟨10.1124/jpet.111.187443⟩
Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with severe motor impairments caused by the loss of dopaminergic innervation of the striatum. Previous studies have demonstrated that positive allosteric modulators (PAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a5e372d0bcf0a5e0ace5a4611d6b2
https://pubmed.ncbi.nlm.nih.gov/22088953
https://pubmed.ncbi.nlm.nih.gov/22088953
Publikováno v:
Cancer Research. 74:323-323
Background: Pharmacodynamics (PD) endpoint assays are important biomarker(s) for target therapy/personalized medicine in oncology drug discovery & development. Identification of the informative PD biomarkers/readouts can support dose selection in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6636994f20e94b348bebfd27153ad2dd
https://doi.org/10.1158/1538-7445.am2014-323
https://doi.org/10.1158/1538-7445.am2014-323
Publikováno v:
Cancer Research. 71:2918-2918
This study was designed to elucidate the selectivity and cellular behavior of several marketed kinase inhibitors used in the treatment of cancer patients. Generally, kinase inhibitors are optimized to inhibit a single cellular target associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ee4607e2a20e42d710318779ac3bf6
https://doi.org/10.1158/1538-7445.am2011-2918
https://doi.org/10.1158/1538-7445.am2011-2918