Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Jacob Beal"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract As synthetic biology becomes increasingly capable and accessible, it is likewise increasingly critical to be able to make accurate biosecurity determinations regarding the pathogenicity or toxicity of particular nucleic acid or amino acid se
Externí odkaz:
https://doaj.org/article/a6a45a2c80124d63b21966c7389b2522
Autor:
Katherine A. Kiwimagi, Justin H. Letendre, Benjamin H. Weinberg, Junmin Wang, Mingzhe Chen, Leandro Watanabe, Chris J. Myers, Jacob Beal, Wilson W. Wong, Ron Weiss
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kiwimagi & Letendre et al. present a workflow to quantitatively define recombinase-based digitizer and predict responses to different input signals. With a mechanistic/phenotypic model that can predict circuit performance, they generate a synthetic c
Externí odkaz:
https://doaj.org/article/d4030bb1a2c34df186adb664ad87a908
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Genome-scale engineering requires the integration of a wide range of in silico and in vivo technologies, as well data management procedures and legal infrastructure. Here the authors provide a list of recommendations to address these challenges.
Externí odkaz:
https://doaj.org/article/6e2b00be562f422f97310610f3d902b6
Autor:
Benjamin H. Weinberg, Jang Hwan Cho, Yash Agarwal, N. T. Hang Pham, Leidy D. Caraballo, Maciej Walkosz, Charina Ortega, Micaela Trexler, Nathan Tague, Billy Law, William K. J. Benman, Justin Letendre, Jacob Beal, Wilson W. Wong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in
Externí odkaz:
https://doaj.org/article/2d4222928cd84b6aa52fbca43ee615fa
Autor:
Jacob Beal, Geoff S Baldwin, Natalie G Farny, Markus Gershater, Traci Haddock-Angelli, Russell Buckley-Taylor, Ari Dwijayanti, Daisuke Kiga, Meagan Lizarazo, John Marken, Kim de Mora, Randy Rettberg, Vishal Sanchania, Vinoo Selvarajah, Abigail Sison, Marko Storch, Christopher T Workman, iGEM Interlab Study Contributors
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252263 (2021)
Reproducibility is a key challenge of synthetic biology, but the foundation of reproducibility is only as solid as the reference materials it is built upon. Here we focus on the reproducibility of fluorescence measurements from bacteria transformed w
Externí odkaz:
https://doaj.org/article/c7ded86e73e9474f93a3c887a1d5cc76
Autor:
Jacob Beal, Miles Rogers
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp n/a-n/a (2020)
Engineering biological organisms is a complex, challenging, and often slow process. Other engineering domains have addressed such challenges with a combination of standardization and automation, enabling a divide‐and‐conquer approach to complexit
Externí odkaz:
https://doaj.org/article/8f656feb4a51458e9289d4d75fc74ea6
Autor:
Peter Lamb, Seema Kantak, Bryan Glaser, Justin Wetter, Bee-Cheng Sim, Jeff Higaki, Jacob Beal, Sara Ollerman, Dileep Pulukkunat, Mandar Bawadekar, Charles Kaplan, Bonnie Hammer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/1667f5e92ad147a390c033bc9d07eb14
Publikováno v:
Logical Methods in Computer Science, Vol Volume 16, Issue 4 (2020)
Field-based coordination has been proposed as a model for coordinating collective adaptive systems, promoting a view of distributed computations as functions manipulating data structures spread over space and evolving over time, called computational
Externí odkaz:
https://doaj.org/article/4dafde12f1464d97979404cc24f1c811
Autor:
James Alastair McLaughlin, Jacob Beal, Göksel Mısırlı, Raik Grünberg, Bryan A. Bartley, James Scott-Brown, Prashant Vaidyanathan, Pedro Fontanarrosa, Ernst Oberortner, Anil Wipat, Thomas E. Gorochowski, Chris J. Myers
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The Synthetic Biology Open Language (SBOL) is a community-developed data standard that allows knowledge about biological designs to be captured using a machine-tractable, ontology-backed representation that is built using Semantic Web technologies. W
Externí odkaz:
https://doaj.org/article/1d81fb42e7504d86aff6be45ec289cae
Autor:
Velia Siciliano, Breanna DiAndreth, Blandine Monel, Jacob Beal, Jin Huh, Kiera L Clayton, Liliana Wroblewska, AnneMarie McKeon, Bruce D. Walker, Ron Weiss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional o
Externí odkaz:
https://doaj.org/article/29e185b3e05642a993be2f596425ebc8