Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jacob B. Axelrad"'
Autor:
Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108293- (2020)
Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused poole
Externí odkaz:
https://doaj.org/article/c36af48cd2dc464096d008d1f2795abf
Autor:
Petko Fiziev, Kadir C. Akdemir, John P. Miller, Emily Z. Keung, Neha S. Samant, Sneha Sharma, Christopher A. Natale, Christopher J. Terranova, Mayinuer Maitituoheti, Samirkumar B. Amin, Emmanuel Martinez-Ledesma, Mayura Dhamdhere, Jacob B. Axelrad, Amiksha Shah, Christine S. Cheng, Harshad Mahadeshwar, Sahil Seth, Michelle C. Barton, Alexei Protopopov, Kenneth Y. Tsai, Michael A. Davies, Benjamin A. Garcia, Ido Amit, Lynda Chin, Jason Ernst, Kunal Rai
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 875-889 (2017)
The extent and nature of epigenomic changes associated with melanoma progression is poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications and transcriptomic analysis, we define chromatin state changes associated wi
Externí odkaz:
https://doaj.org/article/fba1822f041e4353b3a276ef7a4506d3
Supplementary Methods, Figure Legends, Table Legends from Dual Roles of RNF2 in Melanoma Progression
Autor:
Lynda Chin, Jason Ernst, Alexander J. Lazar, Suhendan Ekmekcioglu, James W. Horner, Timothy P. Heffernan, Denai R. Milton, Michelle C. Barton, Elizabeth A. Grimm, Dong Yang, Amiksha Shah, Jacob B. Axelrad, Maura Williams, Neha S. Samant, Sneha Sharma, Emily Z. Keung, Chang-Jiun Wu, Petko Fiziev, Lawrence N. Kwong, Kadir C. Akdemir, Kunal Rai
This file contains supplementary methods, supplementary figure legends, supplementary table legends and supplementary references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7095d0bbb71a789f1d7eb2dcfbc2adc3
https://doi.org/10.1158/2159-8290.22530408.v1
https://doi.org/10.1158/2159-8290.22530408.v1
Autor:
Lynda Chin, Jason Ernst, Alexander J. Lazar, Suhendan Ekmekcioglu, James W. Horner, Timothy P. Heffernan, Denai R. Milton, Michelle C. Barton, Elizabeth A. Grimm, Dong Yang, Amiksha Shah, Jacob B. Axelrad, Maura Williams, Neha S. Samant, Sneha Sharma, Emily Z. Keung, Chang-Jiun Wu, Petko Fiziev, Lawrence N. Kwong, Kadir C. Akdemir, Kunal Rai
Supplementary Figure 1. Western blots. Supplementary Figure 2. Graphs showing tumor volume from mice following intradermal injection of (A) HMEL-BRAF^V600E cells, (B) WM115 cells, (C) 1205 Lu cells, and (D) pMEL-NRAS^G12D overexpressing GFP, RNF2 wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15e831788ff1e3285cfe08fa304cd37
https://doi.org/10.1158/2159-8290.22530411.v1
https://doi.org/10.1158/2159-8290.22530411.v1
Autor:
Lynda Chin, Jason Ernst, Alexander J. Lazar, Suhendan Ekmekcioglu, James W. Horner, Timothy P. Heffernan, Denai R. Milton, Michelle C. Barton, Elizabeth A. Grimm, Dong Yang, Amiksha Shah, Jacob B. Axelrad, Maura Williams, Neha S. Samant, Sneha Sharma, Emily Z. Keung, Chang-Jiun Wu, Petko Fiziev, Lawrence N. Kwong, Kadir C. Akdemir, Kunal Rai
Description of states in 45-state chromatin state model.This table describes the biological annotation of each chromatin state in 50-state chromatin model from HMEL-BRAFV600E cells from ChromHMM program.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6811ad484f0cf089b3c3445a0c0077fb
https://doi.org/10.1158/2159-8290.22530399.v1
https://doi.org/10.1158/2159-8290.22530399.v1
Autor:
Lynda Chin, Jason Ernst, Alexander J. Lazar, Suhendan Ekmekcioglu, James W. Horner, Timothy P. Heffernan, Denai R. Milton, Michelle C. Barton, Elizabeth A. Grimm, Dong Yang, Amiksha Shah, Jacob B. Axelrad, Maura Williams, Neha S. Samant, Sneha Sharma, Emily Z. Keung, Chang-Jiun Wu, Petko Fiziev, Lawrence N. Kwong, Kadir C. Akdemir, Kunal Rai
Binding sites for RNF2 in HMEL-RNF2WT cells. This file contains list of all chromosomal locations that show enrichment by MACS for RNF2 binding by V5 ChIP-Seq in HMEL-RNF2 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ee7481b13a89a8e719bb40e892c9e4
https://doi.org/10.1158/2159-8290.22530405.v1
https://doi.org/10.1158/2159-8290.22530405.v1
Autor:
Kadir C. Akdemir, Sahil Seth, Kunal Rai, Jason Ernst, Jacob B. Axelrad, Emmanuel Martinez-Ledesma, Harshad S. Mahadeshwar, Neha S. Samant, Kenneth Y. Tsai, Ido Amit, Samirkumar B. Amin, Christopher A. Natale, Emily Z. Keung, John P. Miller, Mayinuer Maitituoheti, Christine S. Cheng, Lynda Chin, Alexei Protopopov, Amiksha Shah, Michelle Craig Barton, Mayura Dhamdhere, Sneha Sharma, Petko Fiziev, Christopher Terranova, Benjamin A. Garcia, Michael A. Davies
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 875-889 (2017)
Cell reports, vol 19, iss 4
Cell reports, vol 19, iss 4
The extent and nature of epigenomic changes associated with melanoma progression is poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications and transcriptomic analysis, we define chromatin state changes associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513eccc6e13994e50f42a0fd1fd525ff
http://www.sciencedirect.com/science/article/pii/S2211124717304552
http://www.sciencedirect.com/science/article/pii/S2211124717304552
Autor:
Ayush T. Raman, Ming Tang, Liang Yan, Emily Z. Keung, Guangchun Han, Maura Williams, Linghua Wang, Florian L. Muller, Wei Lien Wang, Amiksha Shah, Norman Zheng, Hunain Alam, Min Gyu Lee, Yu Hsi Lin, Christopher Terranova, Davis R. Ingram, Haoqiang Ying, Edward Q. Chang, Tara Shah, Shan Jiang, Samir B. Amin, Alexander J. Lazar, Elias Orouji, Mayinuer Maitituoheti, Jacob B. Axelrad, Kunal Rai, Nazanin Esmaeili Anvar, Mayura Dhamdhere, Sharmistha Sarkar, Sneha Sharma, Anand K Singh, Neha S. Samant
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108293-(2020)
Cell reports
Cell reports
SUMMARY Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02072ce246e19287ad40b288974bded
Autor:
Dong Yang, Lynda Chin, Sneha Sharma, Jason Ernst, Timothy P. Heffernan, Alexander J. Lazar, Michelle Craig Barton, James W. Horner, Chang-Jiun Wu, Denái R. Milton, Jacob B. Axelrad, Petko Fiziev, Suhendan Ekmekcioglu, Maura Williams, Emily Z. Keung, Lawrence N. Kwong, Elizabeth A. Grimm, Amiksha Shah, Kadir C. Akdemir, Kunal Rai, Neha S. Samant
Publikováno v:
Cancer discovery, vol 5, iss 12
Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8d1318354241d793540458dd52dea9
https://escholarship.org/uc/item/3dg969q0
https://escholarship.org/uc/item/3dg969q0