Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jacob A. Van Winkle"'
Autor:
Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice
Publikováno v:
eLife, Vol 11 (2022)
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestin
Externí odkaz:
https://doaj.org/article/49f905267f26475caccf534d5cf8c0dd
Autor:
David A. Constant, Jacob A. Van Winkle, Eden VanderHoek, Simone E. Dekker, M. Anthony Sofia, Emilie Regner, Nir Modiano, V. Liana Tsikitis, Timothy J. Nice
Publikováno v:
Immunohorizons
The three types of interferon (IFN) have roles in antimicrobial immunity and inflammation that must be properly balanced to maintain tissue homeostasis. For example, IFNs are elevated in the context of inflammatory bowel disease and may synergize wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652bf1b7c6c0e135cbc589cfed12e3c7
https://doi.org/10.4049/immunohorizons.2200025
https://doi.org/10.4049/immunohorizons.2200025
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007940 (2019)
Human norovirus (HNoV) is the leading cause of acute gastroenteritis and is spread by fecal shedding that can often persist for weeks to months after the resolution of symptoms. Elimination of persistent viral reservoirs has the potential to prevent
Externí odkaz:
https://doaj.org/article/956f679c75904a8e81afa024f1afe91a
Autor:
Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd9916b5ce3b6d8271857be63c9806d3
https://doi.org/10.7554/elife.74072.sa2
https://doi.org/10.7554/elife.74072.sa2
Autor:
Jacob A. Van Winkle, Stefan T. Peterson, Elizabeth A. Kennedy, Michael J. Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A. Constant, Austin P. Wright, Lena Li, Maxim Artyomov, Sanghyun Lee, Megan T. Baldridge, Timothy J. Nice
Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8f1b85a8ecc1ca656b1f26a44464d5
https://doi.org/10.1101/2021.06.02.446828
https://doi.org/10.1101/2021.06.02.446828
Publikováno v:
J Virol
Interferon (IFN) family cytokines stimulate genes (interferon-stimulated genes [ISGs]) that are integral to antiviral host defense. Type I IFNs act systemically, whereas type III IFNs act preferentially at epithelial barriers. Among barrier cells, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0517f40820b8f3959507affa5ec48e
https://europepmc.org/articles/PMC7565621/
https://europepmc.org/articles/PMC7565621/
Publikováno v:
Trends in Microbiology. 26:510-524
Persistent viral infections result from evasion or avoidance of sterilizing immunity, extend the timeframe of virus transmission, and can trigger disease. Prior studies in mouse models of persistent infection have suggested that ineffective adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54e14c96fbe429631e7744f8bc639f9
https://doi.org/10.1016/j.tim.2017.10.010
https://doi.org/10.1016/j.tim.2017.10.010
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 7, p e1007940 (2019)
PLoS Pathogens, Vol 15, Iss 7, p e1007940 (2019)
Human norovirus (HNoV) is the leading cause of acute gastroenteritis and is spread by fecal shedding that can often persist for weeks to months after the resolution of symptoms. Elimination of persistent viral reservoirs has the potential to prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1155f727ed1b6bde2b7067f1677930ad
https://pubmed.ncbi.nlm.nih.gov/31329638
https://pubmed.ncbi.nlm.nih.gov/31329638
Autor:
Jacob A. Van Winkle, Bridget A. Robinson, Timothy J. Nice, Matthias Mack, Lena Li, A. Mack Peters, Ruth V. Nouboussi
Publikováno v:
SSRN Electronic Journal.
Viral persistence can contribute to chronic disease and promote virus dissemination. Prior work demonstrated that timely clearance of systemic murine norovirus (MNV) infection depends on cellintrinsic type I interferon responses and adaptive immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ef3d1ff789fe9c9ff65d81c8a19cb7
https://doi.org/10.2139/ssrn.3188484
https://doi.org/10.2139/ssrn.3188484
Autor:
A. Mack Peters, Jacob A. Van Winkle, Timothy J. Nice, Lena Li, Bridget A. Robinson, Matthias Mack, Ruth V. Nouboussi
Publikováno v:
Cell Host & Microbe
Summary Viral persistence can contribute to chronic disease and promote virus dissemination. Prior work demonstrated that timely clearance of systemic murine norovirus (MNV) infection depends on cell-intrinsic type I interferon responses and adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827b61b1fa29d8ad260d5ccce00b7154
https://doi.org/10.1016/j.chom.2018.10.003
https://doi.org/10.1016/j.chom.2018.10.003