Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

Autor: Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt

Publikováno v: Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)

The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi

Externí odkaz: https://doaj.org/article/9426e7d8200a4cacaf75487e613184ae

Measuring and Calculating Current Atmospheric Phosphorous and Nitrogen Loadings to Utah Lake Using Field Samples and Geostatistical Analysis

Autor: Jacob M. Olsen, Gustavious P. Williams, A. Woodruff Miller, LaVere Merritt

Publikováno v: Hydrology, Vol 5, Iss 3, p 45 (2018)

Atmospheric nutrient loading through wet and dry deposition is one of the least understood, yet can be one of the most important, pathways of nutrient transport into lakes and reservoirs. Nutrients, specifically phosphorus and nitrogen, are essential

Externí odkaz: https://doaj.org/article/69939230aa7940f3a21ef1acb611082f

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

Autor: Martin Illemann, Ralf Elvert, Dieter Schmoll, Nicole Ziegler, Andreas Nygaard Madsen, Patrick C. Even, Jacob A Olsen, Marc Foretz, Heiner Glombik, Benoit Viollet, Dalila Azzout-Marniche, Klaus Steinmeyer, Wolfgang Hennerici, Michael Feigh, Aimo Kannt, Karen Mandrup, Jörg Czech, Tamara R. Castañeda

Publikováno v: International Hepatology Communications
International Hepatology Communications, Elsevier, 2020, 4 (7), pp.1056-1072. ⟨10.1002/hep4.1508⟩
Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)
Hepatology Communications
International Hepatology Communications, 2020, 4 (7), pp.1056-1072. ⟨10.1002/hep4.1508⟩

The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d47db58e3758ae0ac431a232885e99
https://www.hal.inserm.fr/inserm-02886252

Selenoureido-iminosugars: A new family of multitarget drugs

Autor: Óscar López, José G. Fernández-Bolaños, Jacob Ingemar Olsen, Mikael Bols, José M. Padrón, Gabriela B. Plata

Publikováno v: European Journal of Medicinal Chemistry. 123:155-160

Herein we report the synthesis of N-alkylated deoxynojirimycin derivatives decorated with a selenoureido motif at the hydrocarbon tether as an example of unprecedented multitarget agents. Title compounds were designed as dual drugs for tackling simul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c1ab8102be0db73c70a78306c0182
https://doi.org/10.1016/j.ejmech.2016.07.021

Exploring the relationship between the conformation and pKa: can a pKavalue be used to determine the conformational equilibrium?

Autor: Mikael Bols, Stephan P. A. Sauer, Jacob Ingemar Olsen, Christian Pedersen

Publikováno v: Organic & Biomolecular Chemistry. 13:3116-3121

Four substituted cis and trans-4,5-dihydroxyhexahydropyridazines that were expected to undergo pH induced conformational switching were synthesized and carefully investigated by NMR analyses and calculations. For two of the compounds a large differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766853559c8024b1aba05ec7f35e1fdc
https://doi.org/10.1039/c4ob02630f