Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jacob A. McPhail"'
Autor:
Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, pro
Externí odkaz:
https://doaj.org/article/195d660c5d9c4b958c577bebd6f5b073
Autor:
Chiara Borsari, Erhan Keles, Jacob A. McPhail, Alexander Schaefer, Rohitha Sriramaratnam, Wojciech Goch, Thorsten Schaefer, Martina De Pascale, Wojciech Bal, Matthias Gstaiger, John E. Burke, Matthias P. Wymann
Publikováno v:
Journal of the American Chemical Society, 144 (14)
Journal of the American Chemical Society
Journal of the American Chemical Society
Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine 5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible-inhibitor scaffold. Here, we delineate a path to target solvent-expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4ac7a3a87ebe57f8fc665894307933
https://hdl.handle.net/20.500.11850/544544
https://hdl.handle.net/20.500.11850/544544
Autor:
John E. Burke, Jacob A. McPhail, Charles J. Eyermann, Kelly Chibale, Stephen Fienberg, Gregory S. Basarab, Lauren B. Arendse
Publikováno v:
ACS Infectious Diseases. 6:3048-3063
Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K) has emerged as a promising new drug target for novel antimalarial therapeutics. In the absence of a reliable high-resolution three-dimensional structure, a homology model of PfPI4K was buil
Autor:
Denise Rageot, Thomas Bohnacker, Erhan Keles, Jacob A. McPhail, Reece M. Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander M. Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E. Burke, Matthias P. Wymann
Publikováno v:
Journal of Medicinal Chemistry. 62:6241-6261
Autor:
Jacob A, McPhail, John E, Burke
Publikováno v:
Advances in experimental medicine and biology. 1274
The lipid kinases that generate the lipid signalling phosphoinositides have been established as fundamental signalling enzymes that control numerous aspects of how cells respond to their extracellular environment. In addition, they play critical role
Autor:
John E. Burke, Jacob A. McPhail
Publikováno v:
Druggable Lipid Signaling Pathways ISBN: 9783030506209
The lipid kinases that generate the lipid signalling phosphoinositides have been established as fundamental signalling enzymes that control numerous aspects of how cells respond to their extracellular environment. In addition, they play critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f608bd970baa585d38b6322238b56c79
https://doi.org/10.1007/978-3-030-50621-6_9
https://doi.org/10.1007/978-3-030-50621-6_9
Autor:
Rohitha Sriramaratnam, Matthias Wymann, Alexander Schäfer, Martina De Pascale, Jacob A. McPhail, John E. Burke, Chiara Borsari, Erhan Keles, Matthias Gstaiger
Publikováno v:
Cancer Research. 81:1377-1377
Inhibitors of the phosphatidylinositol 3-kinase (PI3K) - protein kinase B (PKB/Akt) - mechanistic target of rapamycin (mTOR) axis are considered valuable assets in cancer therapy. A considerable effort has been dedicated to the development of drugs t
Autor:
John E. Burke, Chiara Borsari, Martina De Pascale, Matthias Gstaiger, Erhan Keles, Rohitha Sriramaratnam, Jacob A. McPhail, Matthias Wymann, Alexander Schäfer
Publikováno v:
Cancer Research. 81:291-291
Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics.[1-5] The major obstacles to the successful implementation of PI3K-targeted cancer therapy are on-target adverse effects
Autor:
John E. Burke, Jordan T B Stariha, Heyrhyoung Lyoo, Joshua G. Pemberton, Reece M. Hoffmann, Frank J. M. van Kuppeveld, Wendy van Elst, Jacob A. McPhail, Tamas Balla, Jeroen R.P.M. Strating, Meredith L. Jenkins
Publikováno v:
bioRxiv
SummaryThe lipid kinase PI4KB, which generates phosphatidylinositol 4-phosphate (PI4P), is a key enzyme in regulating membrane transport and is also hijacked by multiple picornaviruses to mediate viral replication. PI4KB can interact with multiple pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839722ad473931503785a82831aa4afa
https://doi.org/10.1101/634592
https://doi.org/10.1101/634592
Autor:
Wendy van Elst, Cameron J. Powell, Frank J. M. van Kuppeveld, John E. Burke, Joshua G. Pemberton, Jeroen R.P.M. Strating, Jordan T B Stariha, Tamas Balla, Meredith L. Jenkins, Heyrhyoung Lyoo, Jacob A. McPhail, Reece M. Hoffmann, Martin J. Boulanger
Publikováno v:
EMBO Reports. Nature Publishing Group
EMBO Rep
EMBO Reports
EMBO Rep
EMBO Reports
The lipid kinase PI4KB, which generates phosphatidylinositol 4-phosphate (PI4P), is a key enzyme in regulating membrane transport and is also hijacked by multiple picornaviruses to mediate viral replication. PI4KB can interact with multiple protein b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4834e886be0bbc7ca5bdb8c97b2ad22
https://dspace.library.uu.nl/handle/1874/388064
https://dspace.library.uu.nl/handle/1874/388064