Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions

Autor: Jacob A. Ludin, Eric G. Krause, Amy R. Alleyne, Meng Liu, Annette D. de Kloet, Colin Sumners, Shormista Kar, Zachary Winder, David J. Pioquinto, Vermali Rodriguez, Yuma T. Ortiz

Publikováno v: Hypertens Res

Brain angiotensin-II (Ang-II) type-1 receptors (AT1Rs), which exert profound effects on normal cardiovascular, fluid, and metabolic homeostasis, are overactivated in and contribute to chronic sympathoexcitation and hypertension. Accumulating evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f6b48d7ab1d2c36bc491fa538339d9
https://pubmed.ncbi.nlm.nih.gov/31953528

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

Autor: Eric G. Krause, Helmut Hiller, Jacob A. Ludin, Annette D. de Kloet, Justin A. Smith, Lei Wang, Deborah A. Scheuer, Colin Sumners, David J. Pioquinto, U. Muscha Steckelings

Publikováno v: de Kloet, A D, Wang, L, Ludin, J A, Smith, J A, Pioquinto, D J, Hiller, H, Steckelings, U M, Scheuer, D A, Sumners, C & Krause, E G 2016, ' Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system ', Brain Structure and Function (Print Edition), vol. 221, no. 2, pp. 891-912 . https://doi.org/10.1007/s00429-014-0943-1

Angiotensin-II acts at its type-1 receptor (AT1R) in the brain to regulate body fluid homeostasis, sympathetic outflow and blood pressure. However, the role of the angiotensin type-2 receptor (AT2R) in the neural control of these processes has receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995c60c9491f28c311c4e3783903440b
https://doi.org/10.1007/s00429-014-0943-1

Abstract 073: Hindbrain Angiotensin Type-2 Receptors and Hypertension

Autor: Lei Wang, Eric G. Krause, Justin A. Smith, Urlike M Steckelings, Annette D. de Kloet, Jacob A. Ludin, Helmut Hiller, Deborah A. Scheuer, Colin Sumners

Publikováno v: Hypertension. 68

The role of the angiotensin type-2 receptor (AT2R) in the neural control of cardiovascular homeostasis and hypertension is not well-characterized. Using a BAC transgenic AT2R-enhanced green fluorescent protein (eGFP) reporter mouse, dense localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830a9e18e7874eab5e560a0eea048288
https://doi.org/10.1161/hyp.68.suppl_1.073

Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats

Autor: Robert W, Regenhardt, Adam P, Mecca, Fiona, Desland, Phillip F, Ritucci-Chinni, Jacob A, Ludin, David, Greenstein, Cristina, Banuelos, Jennifer L, Bizon, Mary K, Reinhard, Colin, Sumners

Publikováno v: Experimental physiology. 99(2)

What is the central question of this study? Activation of angiotensin-converting enzyme 2, resulting in production of angiotensin-(1-7) and stimulation of its receptor, Mas, exerts beneficial actions in a number cardiovascular diseases, including isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7baa6668225b5d01e489d16554fa4f87
https://pubmed.ncbi.nlm.nih.gov/24487246

A Unique "Angiotensin-Sensitive" Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress.

Autor: de Kloet, Annette D., Lei Wang, Pitra, Soledad, Hiller, Helmut, Smith, Justin A., Yalun Tan, Dani Nguyen, Cahill, Karlena M., Sumners, Colin, Stern, Javier E., Krause, Eric G.

Publikováno v: Journal of Neuroscience; 3/29/2017, Vol. 37 Issue 13, p3478-3490, 13p