Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jacob A Kelly"'
Autor:
James M. Holt, Brandon Wilk, Camille L. Birch, Donna M. Brown, Manavalan Gajapathy, Alexander C. Moss, Nadiya Sosonkina, Melissa A. Wilk, Julie A. Anderson, Jeremy M. Harris, Jacob M. Kelly, Fariba Shaterferdosian, Angelina E. Uno-Antonison, Arthur Weborg, Undiagnosed Diseases Network, Elizabeth A. Worthey
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background When applying genomic medicine to a rare disease patient, the primary goal is to identify one or more genomic variants that may explain the patient’s phenotypes. Typically, this is done through annotation, filtering, and then pr
Externí odkaz:
https://doaj.org/article/f2c1bb0577154d0199fe50d36a271be4
Autor:
Harry Klein, Yuguo Xiao, Phillip A. Conklin, Rajanikanth Govindarajulu, Jacob A. Kelly, Michael J. Scanlon, Clinton J. Whipple, Madelaine Bartlett
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3583-3592 (2018)
Forward genetics remains a powerful method for revealing the genes underpinning organismal form and function, and for revealing how these genes are tied together in gene networks. In maize, forward genetics has been tremendously successful, but the s
Externí odkaz:
https://doaj.org/article/fd8832a7bf9344a7a11874ce040acb85
Autor:
Jacob P. Kelly, Adam D. DeVore, JingJing Wu, Bradley G. Hammill, Abhinav Sharma, Lauren B. Cooper, G. Michael Felker, Jonathan P. Piccini, Larry A. Allen, Paul A. Heidenreich, Eric D. Peterson, Clyde W. Yancy, Gregg C. Fonarow, Adrian F. Hernandez
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 24 (2019)
Background Limited data exist to guide treatment for patients with heart failure with preserved ejection fraction and atrial fibrillation, including the important decision regarding rate versus rhythm control. Methods and Results We analyzed the Get
Externí odkaz:
https://doaj.org/article/1c8ead4cf54d45cb85100d654f38d618
Autor:
Lauren B. Cooper, Steven J. Lippmann, Melissa A. Greiner, Abhinav Sharma, Jacob P. Kelly, Gregg C. Fonarow, Clyde W. Yancy, Paul A. Heidenreich, Adrian F. Hernandez
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundPerceived risks of hyperkalemia and acute renal insufficiency may limit use of mineralocorticoid receptor antagonist (MRA) therapy in patients with heart failure, especially those with diabetes mellitus or chronic kidney disease. Methods an
Externí odkaz:
https://doaj.org/article/a5737983b94940c08c3a2d791e00bad8
Autor:
Heidi L Rehm, Joseph T Alaimo, Swaroop Aradhya, Pinar Bayrak-Toydemir, Hunter Best, Rhonda Brandon, Jillian G Buchan, Elizabeth C Chao, Elaine Chen, Jacob Clifford, Ana S Cohen, Laura K Conlin, Soma Das, Kyle W Davis, Daniela del Gaudio, Florencia Del Viso, Christina DiVincenzo, Marcia Eisenberg, Lucia Guidugli, Monia B Hammer, Steven M Harrison, Kathryn E Hatchell, Lindsay Havens Dyer, Lily U Hoang, James M Holt, Vaidehi Jobanputra, Izabela D Karbassi, Hutton M Kearney, Melissa A Kelly, Jacob M Kelly, Michelle L Kluge, Timothy Komala, Paul Kruszka, Lynette Lau, Matthew S Lebo, Christian R Marshall, Dianalee McKnight, Kirsty McWalter, Yan Meng, Narasimhan Nagan, Christian S Neckelmann, Nir Neerman, Zhiyv Niu, Vitoria K Paolillo, Sarah A Paolucci, Denise Perry, Tina Pesaran, Kelly Radtke, Kristen J Rasmussen, Kyle Retterer, Carol J Saunders, Elizabeth Spiteri, Christine M Stanley, Anna Szuto, Ryan J Taft, Isabelle Thiffault, Brittany C Thomas, Amanda Thomas-Wilson, Erin Thorpe, Timothy J Tidwell, Meghan C Towne, Hana Zouk
Variants of uncertain significance (VUS) are a common result of diagnostic genetic testing and can be difficult to manage with potential misinterpretation and downstream costs, including time investment by clinicians. We investigated the rate of VUS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d80f0f4b92e956df2d629d73bc45bef
https://doi.org/10.1101/2022.09.21.22279949
https://doi.org/10.1101/2022.09.21.22279949
Autor:
Jacob P. Kelly, Abhinav Sharma
Publikováno v:
JACC: Heart Failure. 9:836-838
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb6f9a91bb1b990047598a19ba3941f
https://doi.org/10.1016/j.jchf.2021.07.002
https://doi.org/10.1016/j.jchf.2021.07.002
Autor:
Wynn G. Hunter, Jacob P. Kelly, Robert W. McGarrah, Michel G. Khouri, Damian Craig, Carol Haynes, Olga Ilkayeva, Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, Christopher B. Newgard, G. Michael Felker, Adrian F. Hernandez, Eric J. Velazquez, William E. Kraus, Svati H. Shah
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 8 (2016)
BackgroundMetabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction (HFpEF). We sought to deter
Externí odkaz:
https://doaj.org/article/a5ca7e069ca34f67aa4d55540a5f1368
Autor:
Adam D. DeVore, Bradley G. Hammill, Jacob P. Kelly, Todd J. Brophy, Eric D. Peterson, Adrian F. Hernandez, Marat Fudim, Bertram Pitt, Gregg C. Fonarow, Clyde W. Yancy
Publikováno v:
The American Journal of Cardiology. 125:1655-1660
The TOPCAT trial investigated spironolactone vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Although the primary endpoint was not statistically significant, treatment with spironolactone did reduce heart failure h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc375020978712fea64d15929e30fd6
https://doi.org/10.1016/j.amjcard.2020.02.038
https://doi.org/10.1016/j.amjcard.2020.02.038
Autor:
Jacob P. Kelly, Brian J. Andonian, Mahesh J. Patel, Robert W. McGarrah, Zhen Huang, William E. Kraus, Linda K. Shaw, Salvador Borges-Neto, Eric J. Velazquez
Publikováno v:
American Heart Journal. 210:88-97
Objective To identify temporal trends in the use of exercise treadmill testing (ETT) and cardiorespiratory fitness (CRF) estimated by ETT in metabolic equivalents (METs). Patients and methods We compiled an ETT database of all available treadmill tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf46d34998da71a53f3db1d3076f64af
https://doi.org/10.1016/j.ahj.2019.01.001
https://doi.org/10.1016/j.ahj.2019.01.001
Autor:
Madelaine E. Bartlett, Harry Klein, Rajanikanth Govindarajulu, Phillip A Conklin, Jacob A Kelly, Clinton J. Whipple, Michael J. Scanlon, Yuguo Xiao
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3583-3592 (2018)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Forward genetics remains a powerful method for revealing the genes underpinning organismal form and function, and for revealing how these genes are tied together in gene networks. In maize, forward genetics has been tremendously successful, but the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9810b1ca659817a4c23fe2e64af38689
http://g3journal.org/lookup/doi/10.1534/g3.118.200499
http://g3journal.org/lookup/doi/10.1534/g3.118.200499