Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jacob A Herman"'
Publikováno v:
eLife, Vol 9 (2020)
Accurate chromosome segregation requires kinetochores on duplicated chromatids to biorient by attaching to dynamic microtubules from opposite spindle poles, which exerts forces to bring kinetochores under tension. However, kinetochores initially bind
Externí odkaz:
https://doaj.org/article/61333f6fd3e64cb5a2ddb46ae980efee
Autor:
Caileen M Brison, Steven M Mullen, Michelle E Wuerth, Kira Podolsky, Matthew Cook, Jacob A Herman, Justin D Walter, Shannon L Meeks, P Clint Spiegel
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122447 (2015)
The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement the
Externí odkaz:
https://doaj.org/article/29ed0a4b3e9b4c7990838542085fdb11
Autor:
Feyisola P. Olatunji, Michael Pun, Jacob W. Herman, Oscar Romero, Mitchell Maniatopoulos, Joseph D. Latoche, Robert A. Parise, Jianxia Guo, Jan H. Beumer, Carolyn J. Anderson, Clifford E. Berkman
Publikováno v:
Mol Cancer Ther
New targeted chemotherapeutics are urgently needed to minimize off-target toxicity and reduce the high-mortality rate associated with metastatic prostate cancer. Herein, we report on the modular synthesis, pharmacokinetics, and efficacy of two small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d704048493ad988bca36828290750d
https://doi.org/10.1158/1535-7163.mct-22-0160
https://doi.org/10.1158/1535-7163.mct-22-0160
Autor:
Clifford E. Berkman, Carolyn J. Anderson, Jan H. Beumer, Jianxia Guo, Robert A. Parise, Joseph D. Latoche, Mitchell Maniatopoulos, Oscar Romero, Jacob W. Herman, Michael Pun, Feyisola P. Olatunji
Supplementary Data from Modular Smart Molecules for PSMA-Targeted Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2208a0a3a162c0934bede2fe5cdfa0
https://doi.org/10.1158/1535-7163.22523347
https://doi.org/10.1158/1535-7163.22523347
Autor:
Jun Zhu, Patrick Paddison, Raymund L. Yong, Jennifer G. DeLuca, Chad M. Toledo, Jacob A. Herman, Huaien Wang, Margaret Pain, Eunjee Lee
Supplementary Data includes Supplementary Materials and Methods (cell culture protocols, methods for predicting BUB1BR/S status and extracting molecular profiles of GBM tumor cells, genome-wide shRNA screens, GBM cohort data, drug sensitivity measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c492e3a90395c3a9a10ed422c061af
https://doi.org/10.1158/0008-5472.22415405.v1
https://doi.org/10.1158/0008-5472.22415405.v1
Autor:
Jun Zhu, Patrick Paddison, Raymund L. Yong, Jennifer G. DeLuca, Chad M. Toledo, Jacob A. Herman, Huaien Wang, Margaret Pain, Eunjee Lee
Glioblastoma multiforme (GBM) remains a mainly incurable disease in desperate need of more effective treatments. In this study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a predictive marker for aggressiveness an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d608196ef47372d22a5bd11c999c6e
https://doi.org/10.1158/0008-5472.c.6509276.v1
https://doi.org/10.1158/0008-5472.c.6509276.v1
Autor:
Pia Hoellerbauer, Matt C. Biery, Sonali Arora, Yiyun Rao, Emily J. Girard, Kelly Mitchell, Pratiksha Dighe, Megan Kufeld, Daniel A. Kuppers, Jacob A. Herman, Eric C. Holland, Liliana Soroceanu, Nicholas A. Vitanza, James M. Olson, Justin R. Pritchard, Patrick J. Paddison
BackgroundAdult and pediatric tumors display stark differences in their mutation spectra and chromosome alterations. Here, we attempted to identify common and unique gene dependencies and their associated biomarkers among adult and pediatric tumor is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e88e907c9043c2c5a83a45d6372a7f63
https://doi.org/10.1101/2023.01.05.522885
https://doi.org/10.1101/2023.01.05.522885
Autor:
Pia Hoellerbauer, Megan Kufeld, Sonali Arora, Emily J. Girard, Jacob A. Herman, James M. Olson, Patrick J. Paddison
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. To identify genes differentially required for the viability of GBM stem-like cells (GSCs), we performed functional genomic lethality screens comparing GSCs and control human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fe01c941d11e18662785fac84310f3
https://doi.org/10.1101/2022.11.29.518420
https://doi.org/10.1101/2022.11.29.518420
Autor:
Jacob A. Herman, Romario R. Romain, Pia Hoellerbauer, Hazheen K. Shirnekhi, David C. King, Keith F. DeLuca, Erin Osborne Nishimura, Patrick J. Paddison, Jennifer G. DeLuca
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors that contributes to their initiation and evolution. Preventing aneuploidy requires properly functioning kinetochores, which are large protein complexes assembled on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9976595bc94cf2157e3e8588e62cf097
https://doi.org/10.1073/pnas.2208255119
https://doi.org/10.1073/pnas.2208255119
Publikováno v:
Genesdevelopment. 36(7-8)
The identity of human protein-coding genes is well known, yet our in-depth knowledge of their molecular functions and domain architecture remains limited by shortcomings in homology-based predictions and experimental approaches focused on whole-gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82e11342fe06256a5a41acf8b351a67
https://pubmed.ncbi.nlm.nih.gov/35483740
https://pubmed.ncbi.nlm.nih.gov/35483740