Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Jacob A, Blum"'
Autor:
Jayson J. Smith, Seth R. Taylor, Jacob A. Blum, Weidong Feng, Rebecca Collings, Aaron D. Gitler, David M. Miller, III, Paschalis Kratsios
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113857- (2024)
Summary: Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset diseases. It is therefore important to define the molecular makeup of adult MNs in animal models and extract organizing principles. Here, we generate a comp
Externí odkaz:
https://doaj.org/article/953caea15b214f369b4db238ef9ec0ce
Autor:
Tulsi Patel, Jennifer Hammelman, Siaresh Aziz, Sumin Jang, Michael Closser, Theodore L. Michaels, Jacob A. Blum, David K. Gifford, Hynek Wichterle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Patel et al. show that gene expression and regulation in motor neurons is dynamic until juvenile age. A core subprogram (~40% of genes) is faithfully recapitulated in cultured motor neurons, with neuronal activity playing only a modulatory role.
Externí odkaz:
https://doaj.org/article/8c6a3121fd1145a590671bdfc9c21b17
Autor:
Jacob A. Blum, Aaron D. Gitler
Publikováno v:
Trends in Genetics. 38:904-919
Motor neurons are a remarkably powerful cell type in the central nervous system. They innervate and control the contraction of virtually every muscle in the body and their dysfunction underlies numerous neuromuscular diseases. Some motor neurons seem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698e671ab418d1543e19fde07d70aa3f
https://doi.org/10.1016/j.tig.2022.03.016
https://doi.org/10.1016/j.tig.2022.03.016
Autor:
Olivia Gautier, Jacob A. Blum, James Maksymetz, Derek Chen, Christoph Schweingruber, Irene Mei, Anita Hermann, David H. Hackos, Eva Hedlund, John Ravits, Aaron D. Gitler
We performed single-nucleus RNA-sequencing on adult human spinal cord using a neuronal nuclei enrichment strategy. We obtained transcriptomic profiles of >14,000 spinal neurons, including a small population of motor neurons that shares similarities w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68553c88191893ce56f582c2bb0c5625
https://doi.org/10.1101/2023.04.05.535689
https://doi.org/10.1101/2023.04.05.535689
Autor:
Steven Boeynaems, X. Rosa Ma, Vivian Yeong, Garrett M. Ginell, Jian-Hua Chen, Jacob A. Blum, Lisa Nakayama, Anushka Sanyal, Adam Briner, Delphi Van Haver, Jarne Pauwels, Axel Ekman, H. Broder Schmidt, Kousik Sundararajan, Lucas Porta, Keren Lasker, Carolyn Larabell, Mirian A. F. Hayashi, Anshul Kundaje, Francis Impens, Allie Obermeyer, Alex S. Holehouse, Aaron D. Gitler
Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013c06175ee5e3e890d98431771b7dc9
https://doi.org/10.1101/2023.03.09.531820
https://doi.org/10.1101/2023.03.09.531820
Autor:
Prageeth R. Wijewardhane, Maya K. Weigel, Gaurav Chopra, Uriel Rufen-Blanchette, Priya Prakash, Jacob A. Blum, Shane A. Liddelow, Jonathan Fine, Aaron D. Gitler, Mikaela C. Neal, Kimberley D. Bruce, Philip Hasel, Kevin A. Guttenplan, Alexandra E. Münch, Ben A. Barres
Publikováno v:
Nature. 599:102-107
Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease1–6. Here we report an approach to isolate one component of the long-sought astrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d67a7fcbc3e7da504806c704c77cce
https://doi.org/10.1038/s41586-021-03960-y
https://doi.org/10.1038/s41586-021-03960-y
Autor:
Phuong T. Hoang, Kevin A. Guttenplan, Arwa Kathiria, Julia A. Kaltschmidt, Jennifer L. Shadrach, William J. Greenleaf, Olivia Gautier, Sandy Klemm, Lisa Nakayama, Jacob A. Blum, Aaron D. Gitler
Publikováno v:
Nature neuroscience
The spinal cord is a fascinating structure that is responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the spinal cord to diverse peripheral targets. In this study, we profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b76850018f085b70e242f10dea416
https://doi.org/10.1038/s41593-020-00795-0
https://doi.org/10.1038/s41593-020-00795-0
Autor:
Garam Kim, Lisa Nakayama, Jacob A. Blum, Tetsuya Akiyama, Steven Boeynaems, Meena Chakraborty, Julien Couthouis, Eduardo Tassoni-Tsuchida, Caitlin M. Rodriguez, Michael C. Bassik, Aaron D. Gitler
SummaryAntisense oligonucleotide therapy targeting ATXN2—a gene in which mutations cause neurodegenerative diseases spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis—has entered clinical trials in humans. Additional methods to lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a319e1622a07fa2741db5b13555b5751
https://doi.org/10.1101/2021.12.20.473567
https://doi.org/10.1101/2021.12.20.473567
Autor:
Garam Kim, Lisa Nakayama, Jacob A. Blum, Tetsuya Akiyama, Steven Boeynaems, Meenakshi Chakraborty, Julien Couthouis, Eduardo Tassoni-Tsuchida, Caitlin M. Rodriguez, Michael C. Bassik, Aaron D. Gitler
Publikováno v:
Cell Reports. 41:111508
Mutations in the ataxin-2 gene (ATXN2) cause the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). A therapeutic strategy using antisense oligonucleotides targeting ATXN2 has entered clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857daeb421296976fa18f865b28b3d22
https://doi.org/10.1016/j.celrep.2022.111508
https://doi.org/10.1016/j.celrep.2022.111508
Autor:
Gabriel R. Linares, Fen-Biao Gao, Zohar Shipony, Manuel Santana, Jacob A. Blum, Rodrigo Lopez-Gonzalez, Marc Tessier-Lavigne, Gokul Ramaswami, Aaron D. Gitler, Yong Jie Zhang, Kyuho Han, Lisa Nakayama, Justin K. Ichida, Kai Ruan, William J. Greenleaf, Maya Maor-Nof, Laura D. Attardi, Michael C. Bassik, Thomas E. Lloyd, Patricia A. Castruita, Julien Couthouis, Leonard Petrucelli, Nasa Sinnott-Armstrong, David J. Simon, Aviv Nof, Daniel H. Geschwind, Jennifer S. Yokoyama
Publikováno v:
Cell, vol 184, iss 3
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape and transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d841d1b3f0b552a1a6004a2267073e37
https://escholarship.org/uc/item/6cm8z9gp
https://escholarship.org/uc/item/6cm8z9gp