Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jacob R. Remacle"'
Autor:
Wei-Ming Sun, Joel R. Calvin, Jacob R. Remacle, Brian D. Haeberle, Scott A. May, Nikolay Zaborenko, Martin D. Johnson, John Brennan, William D. Diseroad, Michael Miller, James R. Stout
Publikováno v:
Organic Process Research & Development. 16:1017-1038
A fully continuous process including an asymmetric hydrogenation reaction operating at 70 bar hydrogen, aqueous extraction, and crystallization was designed, developed, and demonstrated at pilot scale. This paper highlights safety, quality, and throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305c007f32a2f6b59f0689bd127961a1
https://doi.org/10.1021/op200362h
https://doi.org/10.1021/op200362h
Autor:
Jacob R. Remacle, Amy C. DeBaillie, Christopher P. Ley, Thomas Michael Wilson, Nicholas A. Magnus, Varie David Lee, Perry Clark Heath, Timothy M. Braden, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 16:830-835
This article describes the development and optimization of chemical reactions and subsequent multikilogram preparation of the glucokinase activator (R)-1 to fund clinical evaluation as a potential therapeutic for type II diabetes. The major process d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1fb7722475fb950612116d53a873c37
https://doi.org/10.1021/op300053a
https://doi.org/10.1021/op300053a
Autor:
Moher Eric D, John Allan Rieck, Richard D. Miller, Tracy K. Ditsworth, David A. Hay, Sandra S. K. Borders, Mindy B. Forst, Richard C. Hoying, and Duane A. Pierson, Joseph A. Turpin, Varie David Lee, Ryan J. Linder, Jason S. Cronin, David D. Anderson, and Jacob R. Remacle, Molly D. Brady, Hoard David W, Paul N. Dodson, Christopher A. Beck
Publikováno v:
Organic Process Research & Development. 11:546-559
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53e1e122ffede3fb8c73298de6793ee
https://doi.org/10.1021/op060225f
https://doi.org/10.1021/op060225f
Publikováno v:
ChemInform. 43
A key feature is the use of catalytic zinc triflate, which significantly improves turnover frequency and suppresses epimerization in the α-position of the products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9529b5b6ddb651a9f10f2082079a1dc4
https://doi.org/10.1002/chin.201226033
https://doi.org/10.1002/chin.201226033
Publikováno v:
Organic letters. 14(4)
The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681430cb5ec0420a9534d36c2b0cfba
https://pubmed.ncbi.nlm.nih.gov/22288716
https://pubmed.ncbi.nlm.nih.gov/22288716
Autor:
David L. Varie, Christopher Beck, Sandra K. Borders, Molly D. Brady, Jason S. Cronin, Tracy K. Ditsworth, David A. Hay, David W. Hoard, Richard C. Hoying, Ryan J. Linder, Richard D. Miller, Eric D. Moher, Jacob R. Remacle, John A. Rieck, David D. Anderson, Paul N. Dodson, Mindy B. Forst, Duane A. Pierson, Joseph A. Turpin
Publikováno v:
Organic Process Research & Development; May2007, Vol. 11 Issue 3, p546-559, 14p