Výsledky vyhledávání - "Jacob, Haase"

Telomerase reactivation induces progression of mouse BrafV600E-driven thyroid cancers without telomere lengthening

Autor: Iñigo Landa, Caitlin EM Thornton, Bin Xu, Jacob Haase, Gnana P. Krishnamoorthy, Jingzhu Hao, Jeffrey A Knauf, Zachary T Herbert, María A Blasco, Ronald Ghossein, James A Fagin

Publikováno v: bioRxiv

Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a non-coding region.TERTpromoter mutations (TPMs) are biomarkers of poor prognosis in several tumors, including thyroid can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e194bd5df23da7cd31096ede2e0683
https://doi.org/10.1101/2023.01.24.525280

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Abstract 3068: CREBBP/EP300 disruption promotes tumor progression and confers synthetic lethality in anaplastic thyroid cancers

Autor: Jacob Haase, Talia A. Gebhard, Qi Liu, Sara G. Bernabé, Jingzhu Hao, Chisom Unegbu, Athanasios Bikas, Jun Qi, Iñigo Landa

Publikováno v: Cancer Research. 83:3068-3068

Anaplastic thyroid cancers (ATC) are fast-growing, undifferentiated tumors and almost invariably fatal, primarily due to the lack of effective therapeutic options. The recent approval of dabrafenib plus trametinib for the treatment of BRAFV600E-mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fedd9955cb90bbf115358c11171c1be1
https://doi.org/10.1158/1538-7445.am2023-3068

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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

Autor: Claudia Misiak, Jacob Haase, Stefan Hüttelmaier, Marcell Lederer, Nadine Bley, Markus Glaß, Jean B. Bertoldo, Tommy Fuchs, Simon Müller, Bianca Busch, Patrick Michl, Alice Wedler

Publikováno v: Nucleic Acids Research

The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse prognosis in solid cancers. However, conserved effector pathway(s) and the feasibility of targeting IGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a99770c130aaa2e8af95062bf1562b7
http://europepmc.org/articles/PMC7470957

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MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression

Autor: Hüttelmaier, Danny Misiak, Marcus Bauer, Jana Lange, Jacob Haase, Juliane Braun, Kerstin Lorenz, Claudia Wickenhauser, Stefan

Publikováno v: Cancers; Volume 13; Issue 23; Pages: 5913

Anaplastic thyroid carcinoma (ATC) is the most fatal and rapidly evolving endocrine malignancy invading the head and neck region and accounts for up to 50% of thyroid cancer-associated deaths. Deregulation of the microRNA (miRNA) expression promotes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b23a6c299028f72e0b95cb32f5e66c94

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MiRNA Deregulation Distinguishes Anaplastic Thyroid Carcinoma (ATC) and Supports Upregulation of Oncogene Expression

Autor: Danny, Misiak, Marcus, Bauer, Jana, Lange, Jacob, Haase, Juliane, Braun, Kerstin, Lorenz, Claudia, Wickenhauser, Stefan, Hüttelmaier

Publikováno v: Cancers, Vol 13, Iss 5913, p 5913 (2021)
Cancers

Simple Summary MicroRNAs are essential regulators of gene expression. Their deregulation is associated with a substantial reorganization of the transcriptome in anaplastic thyroid carcinoma (ATC). Here, we present an integrated, combinatorial approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::52b781841876afa8c469edc90b0b9ef5
https://www.mdpi.com/2072-6694/13/23/5913

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OR17-1 MKRN3 Inhibits the Reproductive Axis by Interacting With Key Hypothalamic Substrates and Targeting Neurokinin B to Degradation Pathways

Autor: Ana Paula Abreu, Rona S Carroll, Jacob Haase, Ursula B Kaiser, Iñigo Landa, John C Magnotto, Lydie Naulé, Manar Zoghdan, Alessandra Mancini

Publikováno v: Journal of the Endocrine Society. 6:A616-A616

Background and Objectives Human fertility is attained following puberty due to finely orchestrated events driven by hypothalamic release of the excitatory neuropeptide neurokinin B (NKB), which in turn stimulates the release of kisspeptin and then Gn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e97a3dee58c6c674b8aa4afb601ef144
https://doi.org/10.1210/jendso/bvac150.1277

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The Critical Role of RNA m6A Methylation in Cancer

Autor: Stefan Hüttelmaier, Tao Liu, Qing Lan, Jessica L. Bell, Pei Y. Liu, Jacob Haase

Publikováno v: Cancer Research. 79:1285-1292

Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has emerged as a widespread phenomenon and a critical regulator of transcript e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e410316539f869ef858642c64ef6c6
https://doi.org/10.1158/0008-5472.can-18-2965

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