Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jacob, Cobb"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303863 (2024)
Type 1 diabetes (T1D)-associated hyperglycemia develops, in part, from loss of insulin-secreting beta cells. The degree of glycemic dysregulation and the age at onset of disease can serve as indicators of the aggressiveness of the disease. Tracking b
Externí odkaz:
https://doaj.org/article/0659856f51fa41f1bf00e8c35ddc7d61
Autor:
Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Mahmoud Singer, Fouad Kandeel, Mohamed I. Husseiny
Publikováno v:
Vaccines, Vol 12, Iss 3, p 276 (2024)
A combination therapy of preproinsulin (PPI) and immunomodulators (TGFβ+IL10) orally delivered via genetically modified Salmonella and anti-CD3 promoted glucose balance in in NOD mice with recent onset diabetes. The Salmonella bacteria were modified
Externí odkaz:
https://doaj.org/article/3b15bc7880c64a608ad946ed362ae014
Autor:
Jacob Cobb, Sameh S M Soliman, Mauricio Retuerto, Janine C Quijano, Chris Orr, Mahmoud Ghannoum, Fouad Kandeel, Mohamed I Husseiny
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285905 (2023)
We developed an oral Salmonella-based vaccine that prevents and reverses diabetes in non-obese diabetic (NOD) mice. Related to this, the gastrointestinal tract harbors a complex dynamic population of microorganisms, the gut microbiome, that influence
Externí odkaz:
https://doaj.org/article/0979359f82844f5994d5d5b6c71241c0
Autor:
Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Michael Hensel, Fouad Kandeel, Mohamed I. Husseiny
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated Salmonella MvP728 (ΔhtrA/ΔpurD), cytokines (IL10 and TGFβ) and preproinsulin (PPI) antigen in combination with a sub-therapeutic dose of anti-CD3 mAb was devel
Externí odkaz:
https://doaj.org/article/79113d5122b34a50b040d3e80486f4ba
Publikováno v:
Geosphere. 18:1851-1884
The Cretaceous-Paleogene (K-Pg) contact interval is constrained by vertebrate fossil sites at seven sites in the Tornillo Group and lies within an 80–100-m stratigraphic section between the top of the Javelina Formation and the base of the “log j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c80c91f893544abe23bc22b501bc527
https://doi.org/10.1130/ges02519.1
https://doi.org/10.1130/ges02519.1
Autor:
Jacques C. Mbongue, Jeffrey Rawson, Pablo A. Garcia, Nelson Gonzalez, Jacob Cobb, Fouad Kandeel, Kevin Ferreri, Mohamed I. Husseiny
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We ar
Externí odkaz:
https://doaj.org/article/15614e04a26a48d782330488da2c5f58
Publikováno v:
American family physician. 103(2)
Dystocia (abnormally slow or protracted labor) accounts for 25% to 55% of primary cesarean deliveries. The latent phase of labor begins with onset of regular, painful contractions and continues until 6 cm of cervical dilation. Current recommendations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0144d8c66c6f4f481640f9504e5c2921
https://pubmed.ncbi.nlm.nih.gov/33448772
https://pubmed.ncbi.nlm.nih.gov/33448772
Autor:
Pablo A. Garcia, Nelson Gonzalez, Fouad Kandeel, Mohamed I. Husseiny, Jacob Cobb, Kevin Ferreri, Jacques C. Mbongue, Jeffrey Rawson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a37e44e1bcdc3ad46985d6c5a5ee17
https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full
Autor:
Raquel Evaristo, Alexei Korolev, David J. Smalley, Earle Williams, Robert G. Hallowell, Michael F. Donovan, Kenta T. Hood, Jaclyn Ritzman, Jacob Cobb, Adam Stepanek, Teresa M. Bals-Elsholz, Betty J. Bennett, Mengistu Wolde
Publikováno v:
Journal of Applied Meteorology and Climatology. 54:573-595
The organized behavior of differential radar reflectivity (ZDR) is documented in the cold regions of a wide variety of stratiform precipitation types occurring in both winter and summer. The radar targets and attendant cloud microphysical conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee8a26d6d33d34856aa6e342e39b505
https://doi.org/10.1175/jamc-d-14-0020.1
https://doi.org/10.1175/jamc-d-14-0020.1
Autor:
W. Jacob Cobb, Greta Schuster, Patricia J. Holman, Susan M. Cooper, Adalberto A. Pérez de León, Amanda C. Fisher, Andrea M. James
Publikováno v:
Veterinary parasitology. 197(1-2)
In the United States, the generally non-pathogenic trypanosome of cattle is designated Trypanosoma (Megatrypanum) theileri and is distinguished morphologically from Trypanosoma (M.) cervi, a trypanosome originally described in mule deer and elk. Phyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f72b14bcf2e309eff32d75c2effdef
https://pubmed.ncbi.nlm.nih.gov/23683651
https://pubmed.ncbi.nlm.nih.gov/23683651