Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells

Autor: Eric Eldering, Lisette Waanders, Lieve E H van der Donk, Louis S Ates, Janneke Maaskant, John L van Hamme, Jaco A C van Bruggen, Joanne M Rietveld, Wilbert Bitter, Teunis B H Geijtenbeek, Coenraad P Kuijl

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)

Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphod

Externí odkaz: https://doaj.org/article/31940c490bd64fc09c995d4d78516705

Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells

Autor: Lisette Waanders, Lieve E H van der Donk, Louis S Ates, Janneke Maaskant, John L van Hamme, Eric Eldering, Jaco A C van Bruggen, Joanne M Rietveld, Wilbert Bitter, Teunis B H Geijtenbeek, Coenraad P Kuijl

Publikováno v: Journal for immunotherapy of cancer, 11(4). BioMed Central Ltd.
Waanders, L, van der Donk, L E H, Ates, L S, Maaskant, J, van Hamme, J L, Eldering, E, van Bruggen, J A C, Rietveld, J M, Bitter, W, Geijtenbeek, T B H & Kuijl, C P 2023, ' Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells ', Journal for Immunotherapy of Cancer, vol. 11, no. 4, jitc-2022-005839, pp. 1-13 . https://doi.org/10.1136/jitc-2022-005839
Journal for Immunotherapy of Cancer, 11(4):jitc-2022-005839. BioMed Central
Waanders, L, van der Donk, L E H, Ates, L S, Maaskant, J, van Hamme, J L, Eldering, E, van Bruggen, J A C, Rietveld, J M, Bitter, W, Geijtenbeek, T B H & Kuijl, C P 2023, ' Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells ', Journal for Immunotherapy of Cancer, vol. 11, no. 4, jitc-2022-005839 . https://doi.org/10.1136/jitc-2022-005839
Journal for Immunotherapy of Cancer, 11(4):jitc-2022-005839, 1-13. BioMed Central

BackgroundInterferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2149b7bf3d883993fac5482fcf45611a
https://pure.amc.nl/en/publications/ectopic-expression-of-cgas-in-salmonella-typhimurium-enhances-stingmediated-ifn-response-in-human-macrophages-and-dendritic-cells(946d907b-8e7c-4291-b92d-ff52383ad71b).html

Correction: van Bruggen et al. Overcoming the Hurdles of Autologous T-Cell-Based Therapies in B-Cell Non-Hodgkin Lymphoma. Cancers 2020, 12, 3837

Autor: Arnon P. Kater, Jaco A. C. van Bruggen, Anne W. J. Martens, Sanne H. Tonino

Publikováno v: Cancers, Vol 13, Iss 4738, p 4738 (2021)

In the original article [...]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff57a0afd91943d877de461f87752ac
https://www.mdpi.com/2072-6694/13/19/4738

Chronic Lymphocytic Leukemia Actively Induces T-Cell Dysfunction By Contact-Dependent Signaling Via CD24 and CD52

Autor: Arnon P. Kater, Jaco A. C. van Bruggen, Gaspard Cretenet, J. Joseph Melenhorst, Eric Eldering, Fleur S. Peters

Publikováno v: Blood. 138:3714-3714

Introduction Success rates of autologous T cell-based therapies, such as CAR-T cell therapy, in chronic lymphocytic leukemia (CLL) have been suboptimal and correlate with failure of activation and proliferation of T cells in vitro and in vivo. Previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ac147783ab65f4586fe02ff3bdde74
https://doi.org/10.1182/blood-2021-152495

CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis

Autor: Jaco A. C. van Bruggen, Sabina Kersting, Martijn H. A. van Attekum, Arnon P. Kater, Erik Slinger, Emilie Reinen, Eric Eldering, M Cristina Lebre

Publikováno v: Haematologica
Haematologica, 102(12), 2069-2076. Ferrata Storti Foundation

Chronic lymphocytic leukemia (CLL) cells are provided with essential survival and proliferative signals in the lymph node microenvironment. Here, CLL cells engage in various interactions with bystander cells such as T cells and macrophages. Phenotypi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6565099f09a2eced46cc5c2e37fd724
https://doi.org/10.3324/haematol.2016.157206