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pro vyhledávání: '"Jaclyn R. Espinosa"'
Autor:
Jaclyn R. Espinosa, Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, Mingqing Song, Linda L. Stempora, Jun Wang, Neal N. Iwakoshi, Allan D. Kirk
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR
Externí odkaz:
https://doaj.org/article/9b50cf9d8dea4c1f9954c7be7dcd7634
Autor:
Linda Stempora, Allan D. Kirk, Allison N. Miller, Bartley Adams, Brian I. Shaw, Jaclyn R. Espinosa
Publikováno v:
J Immunol
Costimulation blockade (CoB)–based immunosuppression offers the promise of improved transplantation outcomes with reduced drug toxicity. However, it is hampered by early acute rejections, mediated at least in part by differentiated, CoB-resistant T
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2111
In vitro differentiation of naïve CD4
Publikováno v:
Methods in Molecular Biology ISBN: 9781071602652
In vitro differentiation of naive CD4+ T cells into effector and regulatory subsets offers a means to acquire large numbers of relatively homogeneous cell populations for experimentation. However, culture systems for T cell differentiation described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bddbee7fa07656759ecdcb8724af7d86
https://doi.org/10.1007/978-1-0716-0266-9_7
https://doi.org/10.1007/978-1-0716-0266-9_7
Publikováno v:
American Journal of Transplantation. 18:720-730
Kidney transplant patients treated with belatacept without depletional induction experience higher rates of acute rejection compared to patients treated with conventional immunosuppression. Costimulation blockade-resistant rejection (CoBRR) is associ
Autor:
Matthew K Zuberbuehler, Harmony R. Salzler, Maria Ciofani, Eunchong Park, Morgan E. Parker, Jaclyn R. Espinosa, Joshua D. Wheaton
Publikováno v:
Nature immunology
γδ T cells that produce the cytokine IL-17 (Tγδ17 cells) are innate-like mediators of immunity that undergo effector programming in the thymus. While regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment f
Autor:
C. Victor Hurtig, Cheryl L. Moreton, Juanmarco Gutierrez, Jason J. Lamanna, Lindsey N. Urquia, Thais Federici, Muhibullah S Tora, Jaclyn R. Espinosa, Jacob L. Wagner, Allan D. Kirk, Nicholas M. Boulis
Publikováno v:
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 48
Extensive pre-clinical and clinical studies have searched for therapeutic efficacy of cell-based therapeutics in diseases of the Central Nervous System (CNS) with no other viable options. Allogeneic cells represent the primary source of these therapi
Autor:
Maria Ciofani, Harmony R. Salzler, Jaclyn R. Espinosa, Joshua D. Wheaton, Eunchong Park, Morgan E. Parker, Matthew K Zuberbuehler
Publikováno v:
Nature Immunology. 20:663-663
In the version of this article initially published, the top right plot in Figure 4a was aligned incorrectly. The error has been corrected in the HTML and PDF versions of the article. The original and corrected figures are provided in the accompanying
Publikováno v:
Nature reviews. Nephrology. 12(6)
Antigen-experienced T cells, also known as memory T cells, are functionally and phenotypically distinct from naive T cells. Their enhanced expression of adhesion molecules and reduced requirement for co-stimulation enables them to mount potent and ra
Autor:
M. Song, Antoine Durrbach, Linda Stempora, Allan D. Kirk, Steven E. Bosinger, Roshan P. George, Jennifer Cheeseman, Robert M. Townsend, Jaclyn R. Espinosa, Florence Herr, Alton B. Farris, Gregory K. Tharp
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(4)
Belatacept is a B7-specific fusion protein used to prevent allograft rejection by blocking T cell costimulation. Generally efficacious, it fails to prevent acute rejection in a sizable minority of patients. In experimental models, memory T cells medi