Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jaclyn N. Hayner"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:72-79
Activating transcription factor 3 (ATF3) is a highly regulated protein that is implicated in a wide range of pathological conditions including inflammation and transformation. Transcription from the ATF3 gene is induced by several stress-induced sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f887a90e7475e4337ce7a8b3e701693
https://doi.org/10.1016/j.bbagrm.2018.01.002
https://doi.org/10.1016/j.bbagrm.2018.01.002
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1854:31-38
DNA polymerases require a sliding clamp to achieve processive DNA synthesis. The toroidal clamps are loaded onto DNA by clamp loaders, members of the AAA+family of ATPases. These enzymes utilize the energy of ATP binding and hydrolysis to perform a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75491f6c3051fc9f4b53ce3ebdc2ebc0
https://doi.org/10.1016/j.bbapap.2014.09.019
https://doi.org/10.1016/j.bbapap.2014.09.019
Publikováno v:
Nucleic Acids Research
Sliding clamps are loaded onto DNA by clamp loaders to serve the critical role of coordinating various enzymes on DNA. Clamp loaders must quickly and efficiently load clamps at primer/template (p/t) junctions containing a duplex region with a free 3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6aab7159600691ca29cb85517e39bc
https://doi.org/10.1093/nar/gku774
https://doi.org/10.1093/nar/gku774
Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA
Publikováno v:
Nucleic Acids Research
Excision repair processes are essential to maintain genome stability. A decrease in efficiency and fidelity of these pathways at regions of the genome that can assume non-canonical DNA structures has been proposed as a possible mechanism to explain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6def9c1bee2a65cad9b1145b81cbc7bf
https://doi.org/10.1093/nar/gku417
https://doi.org/10.1093/nar/gku417
Publikováno v:
Journal of Biological Chemistry. 289:5537-5548
Clamp loaders belong to a family of proteins known as ATPases associated with various cellular activities (AAA+). These proteins utilize the energy from ATP binding and hydrolysis to perform cellular functions. The clamp loader is required to load th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fe67a74eee0e1799bbbb048b025bd2
https://doi.org/10.1074/jbc.m113.541466
https://doi.org/10.1074/jbc.m113.541466
Autor:
Marcel E. Dinger, Kerith-Rae Dias, Michael F. Buckley, Mark J. Cowley, Tony Roscioli, Tejaswi Kandula, Ann M. E. Bye, Jaclyn N. Hayner, Jiang Tao, David Miller, Ying Zhu, Michael S. Kilberg, Paula Morris, Rani Sachdev, Michael Cardamone, Edwin P. Kirk, Rebecca Macintosh, Elizabeth E. Palmer
Publikováno v:
Mol Genet Metab
Asparagine Synthetase Deficiency is a recently described cause of profound intellectual disability, marked progressive cerebral atrophy and variable seizure disorder. To date there has been limited functional data explaining the underlying pathophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f21e6510965a1e93137788c3a2937
https://europepmc.org/articles/PMC10152381/
https://europepmc.org/articles/PMC10152381/
Autor:
Maria-Cecilia Lopez, Henry V. Baker, William Donelan, Jaclyn N. Hayner, Jixiu Shan, Mukundh N. Balasubramanian, Lingchen Fu, Michael S. Kilberg
Publikováno v:
The Journal of biological chemistry. 289(35)
Amino acid (AA) limitation in mammalian cells triggers a collection of signaling cascades jointly referred to as the AA response (AAR). In human HepG2 hepatocellular carcinoma, the early growth response 1 (EGR1) gene was induced by either AA deprivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5655af53721155482df161fd40bf6479
https://pubmed.ncbi.nlm.nih.gov/25028509
https://pubmed.ncbi.nlm.nih.gov/25028509
Autor:
Linda B. Bloom, Jaclyn N. Hayner
Publikováno v:
The Journal of biological chemistry. 288(2)
Escherichia coli γ complex clamp loader functions to load the β sliding clamp onto sites of DNA replication and repair. The clamp loader uses the energy of ATP binding and hydrolysis to drive conformational changes allowing for β binding and openi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aed3d5135e6ec4a12ba0d51fa3125c5
https://pubmed.ncbi.nlm.nih.gov/23161545
https://pubmed.ncbi.nlm.nih.gov/23161545
Autor:
Linda B. Bloom, Jaclyn N. Hayner
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6dc242f2b866e57d0063ea08f8f581
https://doi.org/10.1096/fasebj.26.1_supplement.739.7
https://doi.org/10.1096/fasebj.26.1_supplement.739.7
Autor:
Jaclyn N. Hayner, Linda B. Bloom
Publikováno v:
Current biology : CB. 22(5)
SummaryMolecular events in the clamp-loading reaction pathway of DNA replication are revealed by new crystal structures of bacteriophage T4 clamp loader–clamp–DNA complexes that capture two distinct conformations with the clamp open and closed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652492de84d85ce9a35002a9017cd2e6
https://pubmed.ncbi.nlm.nih.gov/22401895
https://pubmed.ncbi.nlm.nih.gov/22401895