Influencing neuroplasticity in stroke treatment with advanced biomaterials-based approaches

Autor: Eric C.H. Ho, Aileen Gracias, Molly S. Shoichet, Jaclyn M. Obermeyer

Publikováno v: Advanced Drug Delivery Reviews. 148:204-218

Since the early 1990s, we have known that the adult brain is not static and has the capacity to repair itself. The delivery of various therapeutic factors and cells have resulted in some exciting pre-clinical and clinical outcomes in stroke models by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7220269b9a99471c7edec752df80ce0d
https://doi.org/10.1016/j.addr.2018.12.012

Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model of stroke

Autor: Molly S. Shoichet, Samantha L. Payne, Anup Tuladhar, Sohrab Zand, Cindi M. Morshead, Jaclyn M. Obermeyer, Ricky Siu

Publikováno v: Biomaterials. 235

Therapeutic delivery to the brain is limited by the blood-brain barrier and is exacerbated by off-target effects associated with systemic delivery, thereby precluding many potential therapies from even being tested. Given the systemic side effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c29d9fbc2a771963412faef4991463c
https://pubmed.ncbi.nlm.nih.gov/31981761

Local Affinity Release

Autor: Jaclyn M. Obermeyer, Vianney Delplace, Molly S. Shoichet

Publikováno v: ACS Nano. 10:6433-6436

The use of hydrogels for therapeutic delivery is a burgeoning area of investigation. These water-swollen polymer matrices are ideal platforms for localized drug delivery that can be further combined with specific ligands or nanotechnologies to advanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3273197cc98db09936a695af923a7fa8
https://doi.org/10.1021/acsnano.6b04308

Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord

Autor: Jaclyn M. Obermeyer, Charles H. Tator, Molly S. Shoichet, Tobias Führmann

Publikováno v: Methods. 84:60-69

Traumatic spinal cord injury (SCI) causes damage and degeneration at and around the lesion site resulting in a loss of function. SCI presents a complex regenerative problem due to the multiple aspects of growth inhibition and the heterogeneity in siz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6b31e179c79042474638236c68f89a
https://doi.org/10.1016/j.ymeth.2015.03.023

Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Autor: Christopher K. McLaughlin, Malgosia M. Pakulska, Irja Elliott Donaghue, Molly S. Shoichet, Tyler N. Shendruk, Jaclyn M. Obermeyer, Anup Tuladhar

Publikováno v: Pakulska, M M, Donaghue, I E, Obermeyer, J, Tuladhar, A, McLaughlin, C K, Shendruk, T & Shoichet, M S 2016, ' Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles ', Science Advances, vol. 2, no. 5, e1600519 . https://doi.org/10.1126/sciadv.1600519
Science Advances

Researchers demonstrate that encapsulation is not necessary to achieve controlled, long-term protein release.
Encapsulation of therapeutic molecules within polymer particles is a well-established method for achieving controlled release, yet chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028db350f978f6cb1ebdc56a427ffcef
https://doi.org/10.1126/sciadv.1600519