Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jaclyn E. Quin"'
Autor:
Charles Arama, Jaclyn E. Quin, Bourèma Kouriba, Ann-Kristin Östlund Farrants, Marita Troye-Blomberg, Ogobara K. Doumbo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A better understanding of stable changes in regulation of gene expression that result from epigenetic events is of great relevance in the development of strategies to prevent and treat infectious diseases. Histone modification and DNA methylation are
Externí odkaz:
https://doaj.org/article/3ccb9d0c6ea2437fa50d919b1e11287f
Autor:
William G. Rice, Kenna Anderes, David Ryckman, Ross D. Hannan, Megan J. Bywater, Elaine Sanij, Jaclyn E. Quin, Nicole Streiner, Adam Siddiqui-Jain, Michael K. Schwaebe, Mustapha Haddach, Mayuko Omori, Chris Proffitt, Sean E. O'Brien, Caroline B. Ho, Josh Bliesath, Amy Lin, Denis Drygin
Supplementary Materials from Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b64b9899bae18205e730a978712b0
https://doi.org/10.1158/0008-5472.22387916.v1
https://doi.org/10.1158/0008-5472.22387916.v1
Autor:
Jaclyn E Quin, Ioana Bujila, Mariama Chérif, Guillaume S Sanou, Ying Qu, Manijeh Vafa Homann, Anna Rolicka, Sodiomon B Sirima, Mary A O'Connell, Andreas Lennartsson, Marita Troye-Blomberg, Issa Nebie, Ann-Kristin Östlund Farrants
Publikováno v:
eLife, Vol 6 (2017)
The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the bas
Externí odkaz:
https://doaj.org/article/39b8b6e0f9804c338ae23e06a2541155
Autor:
Antoni Gañez Zapater, Ann-Kristin Östlund Farrants, Anna Vintermist, Kanwal Tariq, Anna Rolicka, Jaclyn E Quin, Yuan Guo, Fatemeh Sadeghifar, Marie Arsenian-Henriksson
Publikováno v:
The FASEB Journal. 34:10818-10834
Regulation of ribosomal transcription is under tight control from environmental stimuli, and this control involves changes in the chromatin structure. The underlying mechanism of how chromatin changes in response to nutrient and energy supply in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4111708eb3b2c56dafb0ddd06b81ab
https://doi.org/10.1096/fj.202000411r
https://doi.org/10.1096/fj.202000411r
Publikováno v:
Trends in Biochemical Sciences
Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deaminatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3001251a2c7632bca501baa835af5436
Autor:
Ann-Kristin Östlund Farrants, Charles Arama, Jaclyn E Quin, Ioana Bujila, Marita Troye-Blomberg
Publikováno v:
Scandinavian Journal of Immunology
There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children with Pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe810fb690c57f8b1e90ebb4affed02
https://doi.org/10.1111/sji.12932
https://doi.org/10.1111/sji.12932
Autor:
Amit Khot, Amee J George, Ross D. Hannan, Kum Kum Khanna, Carleen Cullinane, Karen E. Sheppard, Elaine Sanij, Denis Drygin, Jessica E. Ahern, Katherine M. Hannan, Nadine Hein, Richard B. Pearson, Grant A. McArthur, Jeannine Diesch, Ricky W. Johnstone, Donald P. Cameron, Keefe T. Chan, Jaclyn E Quin, Gretchen Poortinga, Jennifer R. Devlin
Publikováno v:
Oncotarget
RNA polymerase I (Pol I)-mediated transcription of the ribosomal RNA genes (rDNA) is confined to the nucleolus and is a rate-limiting step for cell growth and proliferation. Inhibition of Pol I by CX-5461 can selectively induce p53-mediated apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e97d1ed07cecb28662c09b55661b89
https://doi.org/10.18632/oncotarget.10452
https://doi.org/10.18632/oncotarget.10452
Autor:
Sodiomon B. Sirima, Jaclyn E Quin, Andreas Lennartsson, Ioana Bujila, Ying Qu, Mary A. O’Connell, Mariama Chérif, Ann-Kristin Östlund Farrants, Guillaume S. Sanou, Issa Nebie, Marita Troye-Blomberg, Manijeh Vafa Homann, Anna Rolicka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491be052ed4f8e2fa0263fbabdb0aade
https://doi.org/10.7554/elife.29156.022
https://doi.org/10.7554/elife.29156.022
Autor:
Ross D. Hannan, Richard B. Pearson, Jennifer R. Devlin, Jaclyn E Quin, Katherine M. Hannan, Donald P. Cameron
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842(6):802-816
The contribution of the nucleolus to cancer is well established with respect to its traditional role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies however, infer that nucleoli contribute a much broader role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8877ab5a8fa73499f249a1086f59a5
Autor:
Grant A. McArthur, James D. Rozario, Meaghan Wall, Denis Drygin, Gretchen Poortinga, Adele Baker, Ross D. Hannan, Donald P. Cameron, Katherine M. Hannan, Carleen Cullinane, Johannes Zuber, Mark A. Guthridge, Jennifer R. Devlin, Elaine Sanij, Jirawas Sornkom, Mark A. Dawson, Nadine Hein, Nhu Y.N. Nguyen, Amee J George, Chun Yew Fong, Simon J. Harrison, Ricky W. Johnstone, Jaclyn E Quin, Megan Pavy, Jeannine Diesch, Richard B. Pearson, Inge Verbrugge, Stuart M. Pitson, Jason A. Powell, Andrew H. Wei
Publikováno v:
Blood. 129(21)
Despite the development of novel drugs, the prospects for many patients with acute myeloid leukemia (AML) remain dismal. This study reveals that the selective inhibitor of RNA polymerase I (Pol I) transcription, CX-5461, effectively treats aggressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1f831335936e04c02ecbcaced9ae9
https://pubmed.ncbi.nlm.nih.gov/28283481
https://pubmed.ncbi.nlm.nih.gov/28283481