Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jaclyn Cika"'
Autor:
Rafael Alcala-Torano, Mariha Islam, Jaclyn Cika, Kwok Ho Lam, Rongsheng Jin, Konstantin Ichtchenko, Charles B. Shoemaker, James A. Van Deventer
Publikováno v:
ACS Chemical Biology. 17:3435-3449
While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe the use of yeast displa
Autor:
Rafael Alcala-Torano, Mariha Islam, Jaclyn Cika, Kwok Ho Lam, Rongsheng Jin, Konstantin Ichtchenko, Charles Shoemaker, James Van Deventer
While covalent drug discovery is reemerging as an important route to small molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe the use of yeast displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9abb02b4792f9567bc7dfbce18df95f1
https://doi.org/10.26434/chemrxiv-2022-lrj2r
https://doi.org/10.26434/chemrxiv-2022-lrj2r
Autor:
Cesar H. Benjumea, James B. Machamer, Elliot J. Glotfelty, Charles B. Shoemaker, Patrick M. McNutt, Christopher A. Angeles, Luis Tenezaca, Kyle E.M. Kelly, Justin T. Whitfield, Jaclyn Cika, Celinia A. Ondeck, Edwin J. Vazquez-Cintron, Konstantin Ichtchenko, Mark Mangkhalakhili, Philip A. Band
Publikováno v:
Sci Transl Med
Botulism is caused by a potent neurotoxin that blocks neuromuscular transmission, resulting in death by asphyxiation. Currently, the therapeutic options are limited and there is no antidote. Here, we harness the structural and trafficking properties