Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jaclyn A. Brennan"'
Autor:
Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov, John A. Rogers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Pacing tools that support small animals and can serve as models for pathogenesis of cardiovascular diseases are currently not available. Here, the authors report a miniaturized wireless battery-free implantable multimodal and multisite pacemaker that
Externí odkaz:
https://doaj.org/article/6dbd42b35661487d89a936efbf8c2f39
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optogenetic technology provides researchers with spatiotemporally precise tools for stimulation, sensing, and analysis of function in cells, tissues, and organs. These tools can offer low-energy and localized approaches due to the use of the transgen
Externí odkaz:
https://doaj.org/article/f2011cf816dd427e9dc6c9bb918b7375
Publikováno v:
JACC: Clinical Electrophysiology. 8:1341-1353
Recently, our laboratory presented functional and molecular evidence for the presence of 2 competing sinoatrial node (SAN) pacemakers in healthy human and rat hearts. Anatomically localized near the superior vena cava and inferior vena cava, the supe
Autor:
Buyan-Ochir Orgil, Deli Dong, Brianna Cathey, Dennis Black, Jeffrey A. Towbin, Joseph F. Pierre, Lu Lu, Jaclyn A. Brennan, Qingqing Gu, Fuyi Xu, Igor R. Efimov, Neely R Alberson, Zaza Khuchua, Undral Munkhsaikhan, Jason N. Johnson, Enkhsaikhan Purevjav
Publikováno v:
Physiological Genomics
Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated with transmembrane protein43 (TMEM43/ LUMA). The study aimed to investigate biological roles of TMEM
Autor:
Jokubas Ausra, Micah Madrid, Rose T. Yin, Jessica Hanna, Suzanne Arnott, Jaclyn A. Brennan, Roberto Peralta, David Clausen, Jakob A. Bakall, Igor R. Efimov, Philipp Gutruf
Publikováno v:
Science Advances. 8
Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety
Autor:
Mohammed A. Swid, Leif A. Havton, Peter Hanna, Elizabeth H. Smith, Sirisha Achanta, Jeffrey L. Ardell, John D. Tompkins, Pradeep S. Rajendran, Robert L. Lux, Natalia P. Biscola, Kalyanam Shivkumar, Alison Moss, Jin Chen, Joseph Hadaya, Jaclyn A. Brennan, Igor R. Efimov, Rajanikanth Vadigepalli, Zixi (Jack) Cheng, James S. Schwaber, Michael J. Dacey, Shaina Robbins, Donald B. Hoover, Shumpei Mori, Stanley G. Peirce
Publikováno v:
Circ Res
Circulation research, vol 128, iss 9
Circulation research, vol 128, iss 9
Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results. Objecti
Autor:
Jaclyn A. Brennan, Igor R. Efimov
Publikováno v:
JACC: Clinical Electrophysiology. 7:1345-1347
Autor:
Jeffrey Schmeckpeper, Kyungsoo Kim, Sharon A George, Dan Blackwell, Jaclyn A Brennan, Igor R Efimov, Bjorn C Knollmann
BackgroundVentricular tachycardia (VT) is responsible for sudden death in chronic ischemic heart disease (CIHD) patients. The cardiac ryanodine receptor (RyR2) releases Ca2+ from the sarcoplasmic reticulum (SR) and links electrical excitation to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c888d76c54d2a4c1ab62a67793beb8f
https://doi.org/10.1101/2022.06.24.496861
https://doi.org/10.1101/2022.06.24.496861
Autor:
Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak-Young Ahn, Grace Wickerson, Abraham Vázquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers
Publikováno v:
Science
Science, 376(6596)
Science, 376(6596)
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction proc
Autor:
Xiangang Zong, Jaclyn A. Brennan, Igor R. Efimov, Verena F. Brox, Christian Kupatt, Carsten T. Wotjak, Audrys G. Pauža, Andreas Scharr, Rai Zhang, Rasmus Gönner, René D. Rötzer, Konstantin Hennis, Christian Wahl-Schott, Henggui Zhang, Christian Gruner, Martin Biel, Tilman Ziegler, Markus Moser, Verena Mehlfeld, Elvir Becirovic, Stefanie Fenske
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
Nature Communications
Nature communications, London : Nature Publishing Group, 2020, vol. 11, no. 1, 5555, p. 1-22
Nature Communications
Nature communications, London : Nature Publishing Group, 2020, vol. 11, no. 1, 5555, p. 1-22
It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic nervous system. We addressed this question using