Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jaclyn A, Brennan"'
Autor:
Philipp Gutruf, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov, John A. Rogers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Pacing tools that support small animals and can serve as models for pathogenesis of cardiovascular diseases are currently not available. Here, the authors report a miniaturized wireless battery-free implantable multimodal and multisite pacemaker that
Externí odkaz:
https://doaj.org/article/6dbd42b35661487d89a936efbf8c2f39
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optogenetic technology provides researchers with spatiotemporally precise tools for stimulation, sensing, and analysis of function in cells, tissues, and organs. These tools can offer low-energy and localized approaches due to the use of the transgen
Externí odkaz:
https://doaj.org/article/f2011cf816dd427e9dc6c9bb918b7375
Publikováno v:
JACC: Clinical Electrophysiology. 8:1341-1353
Recently, our laboratory presented functional and molecular evidence for the presence of 2 competing sinoatrial node (SAN) pacemakers in healthy human and rat hearts. Anatomically localized near the superior vena cava and inferior vena cava, the supe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b784460ccf2d3eaf80990bb8425494e1
https://doi.org/10.1016/j.jacep.2022.08.003
https://doi.org/10.1016/j.jacep.2022.08.003
Autor:
Buyan-Ochir Orgil, Deli Dong, Brianna Cathey, Dennis Black, Jeffrey A. Towbin, Joseph F. Pierre, Lu Lu, Jaclyn A. Brennan, Qingqing Gu, Fuyi Xu, Igor R. Efimov, Neely R Alberson, Zaza Khuchua, Undral Munkhsaikhan, Jason N. Johnson, Enkhsaikhan Purevjav
Publikováno v:
Physiological Genomics
Broad cellular functions and diseases including muscular dystrophy, arrhythmogenic right ventricular cardiomyopathy (ARVC5) and cancer are associated with transmembrane protein43 (TMEM43/ LUMA). The study aimed to investigate biological roles of TMEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a78a264bdd76c8b9c5b9f8cbd6036e1
https://doi.org/10.1152/physiolgenomics.00066.2021
https://doi.org/10.1152/physiolgenomics.00066.2021
Autor:
Jokubas Ausra, Micah Madrid, Rose T. Yin, Jessica Hanna, Suzanne Arnott, Jaclyn A. Brennan, Roberto Peralta, David Clausen, Jakob A. Bakall, Igor R. Efimov, Philipp Gutruf
Publikováno v:
Science Advances. 8
Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79cefa7fd0b068d9d62558f9f964520
https://doi.org/10.1126/sciadv.abq7469
https://doi.org/10.1126/sciadv.abq7469
Autor:
Jeffrey Schmeckpeper, Kyungsoo Kim, Sharon A George, Dan Blackwell, Jaclyn A Brennan, Igor R Efimov, Bjorn C Knollmann
BackgroundVentricular tachycardia (VT) is responsible for sudden death in chronic ischemic heart disease (CIHD) patients. The cardiac ryanodine receptor (RyR2) releases Ca2+ from the sarcoplasmic reticulum (SR) and links electrical excitation to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c888d76c54d2a4c1ab62a67793beb8f
https://doi.org/10.1101/2022.06.24.496861
https://doi.org/10.1101/2022.06.24.496861
Autor:
Mohammed A. Swid, Leif A. Havton, Peter Hanna, Elizabeth H. Smith, Sirisha Achanta, Jeffrey L. Ardell, John D. Tompkins, Pradeep S. Rajendran, Robert L. Lux, Natalia P. Biscola, Kalyanam Shivkumar, Alison Moss, Jin Chen, Joseph Hadaya, Jaclyn A. Brennan, Igor R. Efimov, Rajanikanth Vadigepalli, Zixi (Jack) Cheng, James S. Schwaber, Michael J. Dacey, Shaina Robbins, Donald B. Hoover, Shumpei Mori, Stanley G. Peirce
Publikováno v:
Circ Res
Circulation research, vol 128, iss 9
Circulation research, vol 128, iss 9
Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results. Objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5b1c049668192a7b1f2126ee974afa
https://doi.org/10.1161/circresaha.120.318458
https://doi.org/10.1161/circresaha.120.318458
Autor:
Jaclyn A. Brennan, Igor R. Efimov
Publikováno v:
JACC: Clinical Electrophysiology. 7:1345-1347
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f2081e80a747e68d1d9df4939e0b7b
https://doi.org/10.1016/j.jacep.2021.04.006
https://doi.org/10.1016/j.jacep.2021.04.006
Autor:
Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak-Young Ahn, Grace Wickerson, Abraham Vázquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers
Publikováno v:
Science
Science, 376(6596)
Science, 376(6596)
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44c9871dd076b44814f24e533e7b2b5
https://pubmed.ncbi.nlm.nih.gov/35617399
https://pubmed.ncbi.nlm.nih.gov/35617399
Autor:
Xiangang Zong, Jaclyn A. Brennan, Igor R. Efimov, Verena F. Brox, Christian Kupatt, Carsten T. Wotjak, Audrys G. Pauža, Andreas Scharr, Rai Zhang, Rasmus Gönner, René D. Rötzer, Konstantin Hennis, Christian Wahl-Schott, Henggui Zhang, Christian Gruner, Martin Biel, Tilman Ziegler, Markus Moser, Verena Mehlfeld, Elvir Becirovic, Stefanie Fenske
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
Nature Communications
Nature communications, London : Nature Publishing Group, 2020, vol. 11, no. 1, 5555, p. 1-22
Nature Communications
Nature communications, London : Nature Publishing Group, 2020, vol. 11, no. 1, 5555, p. 1-22
It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic nervous system. We addressed this question using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd4af068b231e45bb8651823394936
https://doaj.org/article/6c6af2794e4b4707a82af208feb04493
https://doaj.org/article/6c6af2794e4b4707a82af208feb04493