Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Jaclyn A, Biegel"'
Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors
Autor:
Eirini Christodoulou, Venkata Yellapantula, Katrina O’Halloran, Liya Xu, Jesse L. Berry, Jennifer A. Cotter, Anya Zdanowicz, Leo Mascarenhas, James F. Amatruda, Dejerianne Ostrow, Moiz Bootwalla, Xiaowu Gai, Fariba Navid, Jaclyn A. Biegel
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid
Externí odkaz:
https://doaj.org/article/2d4c69443c07400f8b129c34095fae56
Autor:
Elyssa Y. Wong, Liya Xu, Lishuang Shen, Mary E. Kim, Ashley Polski, Rishvanth K. Prabakar, Rachana Shah, Rima Jubran, Jonathan W. Kim, Jaclyn A. Biegel, Xiaowu Gai, Peter Kuhn, James Hicks, Jesse L. Berry
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
Abstract Germline alterations in the RB1 tumor suppressor gene predispose patients to develop retinoblastoma (RB) in both eyes. While similar treatment is given for each eye, there is often a variable therapeutic response between the eyes. Herein, we
Externí odkaz:
https://doaj.org/article/cba62b9753aa46e6a2d5607deeabe06c
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 885-893 (2021)
Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate pr
Externí odkaz:
https://doaj.org/article/36225cc591ed41b89d2c56eb4a2cafd2
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1293-1299 (2021)
The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) pro
Externí odkaz:
https://doaj.org/article/f8aa19448b194282a64ae08f50d5999a
Autor:
Thao T. Truong, Alex Ryutov, Utsav Pandey, Rebecca Yee, Lior Goldberg, Deepa Bhojwani, Paibel Aguayo-Hiraldo, Benjamin A. Pinsky, Andrew Pekosz, Lishuang Shen, Scott D. Boyd, Oliver F. Wirz, Katharina Röltgen, Moiz Bootwalla, Dennis T. Maglinte, Dejerianne Ostrow, David Ruble, Jennifer H. Han, Jaclyn A. Biegel, Maggie Li, ChunHong Huang, Malaya K. Sahoo, Pia S. Pannaraj, Maurice O'Gorman, Alexander R. Judkins, Xiaowu Gai, Jennifer Dien Bard
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103355- (2021)
Background: There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses
Externí odkaz:
https://doaj.org/article/42209873b5b849b2806a3d10b8822b27
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at t
Externí odkaz:
https://doaj.org/article/8bc3c67240da4c278b62c7403755aa51
Autor:
Kristiyana, Kaneva, Theodore G, Schurr, Tatiana V, Tatarinova, Jonathan, Buckley, Daria, Merkurjev, Petr, Triska, Xiyu, Liu, James, Done, Dennis T, Maglinte, Dennis, Deapen, Amie, Hwang, Joshua D, Schiffman, Timothy J, Triche, Jaclyn A, Biegel, Xiaowu, Gai
Publikováno v:
Mitochondrion. 67:6-14
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583fb7a04280b6b04aded9ba10e6af76
https://doi.org/10.1016/j.mito.2022.09.002
https://doi.org/10.1016/j.mito.2022.09.002
Autor:
Daria V. Babushok, Jamie L. Duke, Hongbo M. Xie, Natasha Stanley, Jamie Atienza, Nieves Perdigones, Peter Nicholas, Deborah Ferriola, Yimei Li, Hugh Huang, Wenda Ye, Jennifer J.D. Morrissette, Jane Kearns, David L. Porter, Gregory M. Podsakoff, Laurence C. Eisenlohr, Jaclyn A. Biegel, Stella T. Chou, Dimitrios S. Monos, Monica Bessler, Timothy S. Olson
Publikováno v:
Blood Advances, Vol 1, Iss 22, Pp 1900-1910 (2017)
Abstract: Acquired aplastic anemia (aAA) is an acquired deficiency of early hematopoietic cells, characterized by inadequate blood production, and a predisposition to myelodysplastic syndrome (MDS) and leukemia. Although its exact pathogenesis is unk
Externí odkaz:
https://doaj.org/article/2d4ec009b9d644f0835cd7403d43ae3c
Autor:
Jeffrey Jean, Alexandra E. Kovach, Andrew Doan, Matthew Oberley, Jianling Ji, Ryan J. Schmidt, Jaclyn A. Biegel, Deepa Bhojwani, Gordana Raca
Publikováno v:
Blood Advances. 6:3343-3346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f440c026e9ec94caeefa7510f9fa96e7
https://doi.org/10.1182/bloodadvances.2021006328
https://doi.org/10.1182/bloodadvances.2021006328
Autor:
Jaclyn A. Biegel, Tamim H. Shaikh, Hongbo Xie, Juan Carlos Perin, Laura Tooke, Alexander R. Judkins, Hakon Hakonarson, Xiaowu Gai, Angela J. Sievert, Eric M. Jackson
Supplementary Table S1 from Genomic Analysis Using High-Density Single Nucleotide Polymorphism-Based Oligonucleotide Arrays and Multiplex Ligation-Dependent Probe Amplification Provides a Comprehensive Analysis of INI1/SMARCB1 in Malignant Rhabdoid T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f887c7359bc23bef05d12e222c95850
https://doi.org/10.1158/1078-0432.22440526
https://doi.org/10.1158/1078-0432.22440526
