Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials

Autor: Matt S. Zinter, Daniela Markovic, Lisa A. Asaro, Vinay M. Nadkarni, Patrick S. McQuillen, Pratik Sinha, Michael A. Matthay, Marc G. Jeschke, Michael S. D. Agus, Anil Sapru, Michael Agus, Kerry Coughlin-Wells, Kyle Hughes, Jaclyn French, Meghan Fitzgerald, Vijay Srinivasan, Martha Sisko, Ranjit S. Chima, Kelli Howard, Rhonda Jones, Neal J Thomas, Debbie Spear, Simon Li, Alan Pinto, Peter Eldridge, Christopher Newth, Jeni Kwok, Amanda B Hassinger, Haiping Qiao, Kris Bysani, Tracey Monjure, Edward Vincent Faustino, Joana Tala, Sarah A Kandil, Tyler Quinn, Eliotte Hirshberg, Jennifer Lilley, Kupper Wintergerst, Janice E Sullivan, Kristen Lee, Adam Schwarz, Cathy Flores, Ofelia Vargas-Shiraishi, Lauren Sorce, Lauren Marsillio, Avani Shukla, Natalie Cvijanovich, Heidi Flori, Becky Brumfield, Cheryl Stone, Mary Dahmer, Chaandini Jayachandran, Myke Federman, Kayley Wong, Sitaram S Vangala, Matteo Pellegrini, Brunilda Balliu, Kinisha P Gala, Theresa Kirkpatrick, Tanaya Deshmukh, Manvita Mareboina, Nguyen Do, Neda Ashtari, Anna Ratiu, Sholeen Nett, Marcy Singleton, Dean Jarvis, Mary McNally, Karlyn Martini, Neethi Pinto, Grace Chong, Chiara Rodgers, Shirley Viteri, Ramany John, Teresa Mulholland, Gwen Pellicciotti, Patrick McQuillen, Matt Zinter, Shrey Goel, Mustafa Alkhouli, Anne McKenzie, Denise Villarreal-Chico

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 207:945-949

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84930a79588a371f05007dbac48d7e01
https://doi.org/10.1164/rccm.202210-1988le

Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control

Autor: Katherine V. Biagas, Veronica J. Hinton, Natalie R. Hasbani, Peter M. Luckett, David Wypij, Vinay M. Nadkarni, Michael S.D. Agus, Vijay Srinivasan, Peter M. Mourani, Ranjit Chima, Neal J. Thomas, Simon Li, Alan Pinto, Christopher Newth, Amanda Hassinger, Kris Bysani, Kyle J. Rehder, Edward Vincent Faustino, Sarah Kandil, Eliotte Hirshberg, Kupper Wintergerst, Adam Schwarz, Dayanand Bagdure, Lauren Marsillio, Natalie Cvijanovich, Nga Pham, Michael Quasney, Heidi Flori, Myke Federman, Sholeen Nett, Neethi Pinto, Shirley Viteri, James Schneider, Shivanand Medar, Anil Sapru, Patrick McQuillen, Christopher Babbitt, John C. Lin, Philippe Jouvet, Ofer Yanay, Christine Allen, Lisa Asaro, Kerry Coughlin-Wells, Jaclyn French, Aruna Natarajan

Publikováno v: J Pediatr

Objectives To investigate adaptive skills, behavior, and quality health-related quality of life in children from 32 centers enrolling in the Heart And Lung Failure-Pediatric INsulin Titration randomized controlled trial. Study design This prospective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c800c78bf9e6206767cb765fac3cde2
https://pubmed.ncbi.nlm.nih.gov/31910992

Design and rationale of Heart and Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children

Autor: David Wypij, Donna Duva, Jamin L. Alexander, Natalie R Hasbani, Vijay Srinivasan, Lisa A. Asaro, Ellie Hirshberg, Garry M. Steil, Carmen L. Soto-Rivera, Jaclyn French, Martha A. Q. Curley, Michael S. D. Agus, Peter M. Luckett, Edward Vincent S. Faustino, Kerry Coughlin-Wells, Martha Sisko, Vinay M. Nadkarni

Publikováno v: Contemporary clinical trials

Objectives Test whether hyperglycemic critically ill children with cardiovascular and/or respiratory failure experience more ICU-free days when assigned to tight glycemic control with a normoglycemic versus hyperglycemic blood glucose target range. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6dea7d91fc52361887609a708bf8fb
https://pubmed.ncbi.nlm.nih.gov/28042054