Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jacky Van Dun"'
Autor:
Peter ten Holte, Boudewijn Janssens, Sandrine Gaurrand, Janine Arts, Jacky van Gompel, Virginie Sophie Poncelet, Patrick Angibaud, Ann Marien, Hans De Winter, Bruno Roux, An Aerts, Verdonck Marc Gustaaf Celine, Jacky Van Dun, Luc Van Hijfte, Kristof Van Emelen, Isabelle Noëlle Constance Pilatte, Eddy Jean Edgard Freyne, Wim Floren, Michel Janicot, Sven Franciscus Anna Van Brandt, Jean-Michel Argoullon, Laurence Queguiner
Publikováno v:
European Journal of Medicinal Chemistry. 40:597-606
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Autor:
Roel Straetemans, Marc Aerts, Timothy E. O'Brien, Luc Wouters, Jacky Van Dun, Luc Bijnens, Michel Janicot, Tomasz Burzykowski
Publikováno v:
Biometrical Journal. 47:299-308
In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interactio
Autor:
Patrick Rene Angibaud, Eddy Jean Edgard Freyne, Christophe Meyer, Jacky Van Dun, Gerda Smets, Marc Venet, Isabelle Noëlle Constance Pilatte, Laurence Mevellec, Virginie Sophie Poncelet, Bruno Roux, Geert Mannens, Ashis K. Saha, David William End, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patricia Lezouret
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4361-4364
Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potenti
Autor:
Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for
Autor:
Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Autor:
Luc Van Puyvelde, Simon G. Mathenge, Miroslav Cik, Francis P. Mudida, Josée E. Leysen, Wouters Walter Boudewijn Leopo, Jacky Van Dun, Ilse Van der Lindin, Anne Simone Josephine Lesage, Giovanni Appendino, Norbert De Kimpe, Weidong He
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3245-3255
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic d
Autor:
Bruno Roux, Luc Van Hijfte, Jacky van Gompel, Claire Mackie, Sven Franciscus Anna Janssen Pharm. Van Brandt, Marc Noppe, Ann Marien, David Speybrouck, Lut Janssen, Marc Du Jardin, Wim Floren, Eddy Jean Edgard Freyne, Michel Janicot, Kristof Van Emelen, Jacky Van Dun, Ron Gilissen, Isabelle Noëlle Constance Pilatte, Virginie Sophie Poncelet, Patrick Angibaud, Verdonck Marc Gustaaf Celine, Peter ten Holte, Sandrine Gaurrand, Martin John Page, Jozef Peeters, Laurence Decrane, Janine Arts, Laurence Queguiner
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
Pursuing our efforts in designing 5-pyrimidylhydroxamic acid anti-cancer agents, we have identified a new series of potent histone deacetylase (HDAC) inhibitors. These compounds exhibit enzymatic HDAC inhibiting properties with IC(50) values in the n
Autor:
Wouters Walter Boudewijn Leopo, Alfons H. M. Raeymaekers, Ann Dillen, Jacky Van Dun, Marc Gaston Venet, Jozef H L Van Gelder, Roland De Coster, Eddy Jean Edgard Freyne, Marcel August Constant Janssen, M. D. W. G. Krekels, Gerard Charles Sanz
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 37:1049-1054
R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole) is a selective, non-steroidal aromatase inhibitor containing an asymmetric carbon atom. In this paper, we compare the effects of R76713 (racemate) with its enantiomer
Publikováno v:
The Journal of antibiotics. 56(11)
During the course of a screening program intended to identify new antiproliferative agents, a new bafilolide metabolite was discovered. R176502 (1) was isolated from the liquid fermentation cultures of a novel Micromonospora species found in African
Autor:
Jacky Van Dun, Wouters Walter Boudewijn Leopo, P.F.M. Janssen, Mady Verwimp, W. Gommeren, Alain Schotte, Pierre M. Laduron, Josée E. Leysen, Paul Van Gompel
Publikováno v:
Drug Development Research. 8:15-26
Chemical compounds synthesized at Janssen Pharmaceutica are commonly used to identify and characterize neurotransmitter receptors in the brain and in the peripheral system through in vitro or in vivo binding techniques. In this regard, they have play