Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jacky Guy"'
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Cre/Lox technology is a powerful tool in the mouse genetics tool-box as it enables tissue-specific and inducible mutagenesis of specific gene loci. Correct interpretation of phenotypes depends upon knowledge of the Cre expression pattern in the chose
Externí odkaz:
https://doaj.org/article/0731e32cd2ac4bdeaf736c3b56922b21
Autor:
Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Epigenetic information is transmitted from mother to daughter cells through mitosis. Here, the authors isolate native chromosomes from metaphase-arrested cells and perform LC-MS/MS to identify chromosome-bound proteins in pluripotent stem cells durin
Externí odkaz:
https://doaj.org/article/73176d0dba7348dcb968ea5de1aa87c6
Autor:
Claudio De Felice, Floriana Della Ragione, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Lucia Ciccoli, Francesco Scalabrì, Federico Marracino, Michele Madonna, Giuseppe Belmonte, Laura Ricceri, Bianca De Filippis, Giovanni Laviola, Giuseppe Valacchi, Thierry Durand, Jean-Marie Galano, Camille Oger, Alexandre Guy, Valérie Bultel-Poncé, Jacky Guy, Stefania Filosa, Joussef Hayek, Maurizio D'Esposito
Publikováno v:
Neurobiology of Disease, Vol 68, Iss , Pp 66-77 (2014)
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). High circulating
Externí odkaz:
https://doaj.org/article/f05bc40df8d64a928adb14bd5f3ac97e
Autor:
David M. Katz, Joanne E. Berger-Sweeney, James H. Eubanks, Monica J. Justice, Jeffrey L. Neul, Lucas Pozzo-Miller, Mary E. Blue, Diana Christian, Jacqueline N. Crawley, Maurizio Giustetto, Jacky Guy, C. James Howell, Miriam Kron, Sacha B. Nelson, Rodney C. Samaco, Laura R. Schaevitz, Coryse St. Hillaire-Clarke, Juan L. Young, Huda Y. Zoghbi, Laura A. Mamounas
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 733-745 (2012)
In September of 2011, the National Institute of Neurological Disorders and Stroke (NINDS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the International Rett Syndrome Foundation (IRSF) and the Rett Syn
Externí odkaz:
https://doaj.org/article/e47f996a0ef64ccab86e468a2e1e40e3
Publikováno v:
Paton, K M, Selfridge, J, Guy, J & Bird, A 2022, ' Comparative analysis of potential broad-spectrum neuronal Cre drivers ', Wellcome Open Research, vol. 7, no. 185 . https://doi.org/10.12688/wellcomeopenres.17965.1
Cre/Lox technology is a powerful tool in the mouse genetics tool-box as it enables tissue-specific and inducible mutagenesis of specific gene loci. Correct interpretation of phenotypes depends upon knowledge of the Cre expression pattern in the chose
Autor:
Silvia Leoncini, Claudio De Felice, Roberto Guerranti, Jacky Guy, Alessio Cortelazzo, Anna Maria Timperio, Lello Zolla, Cinzia Signorini, Thierry Durand, Joussef Hayek
Publikováno v:
Journal of Proteomics
Journal of Proteomics, Elsevier, 2020, 210, pp.103537. ⟨10.1016/j.jprot.2019.103537⟩
Journal of Proteomics, Elsevier, 2020, 210, pp.103537. ⟨10.1016/j.jprot.2019.103537⟩
International audience; Rett syndrome (RTT) is a leading cause of severe intellectual disability in females, caused by de novo loss-of function mutations in the X-linked methyl-CpG binding protein 2 (MECP2). To better investigate RTT disease progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198ecd53de98969edd29ada879687b47
https://hal.umontpellier.fr/hal-03377592
https://hal.umontpellier.fr/hal-03377592
Autor:
Jim Selfridge, Martha V. Koerner, Stuart Cobb, Ralph D. Hector, Adrian Bird, Kamal K.E. Gadalla, Diana De Sousa, Rebekah Tillotson, Jacky Guy
Publikováno v:
Tillotson, R, Selfridge, J, Koerner, M V, Gadalla, K K E, Guy, J, Sousa, D D, Hector, R D, Cobb, S R & Bird, A 2017, ' Radically truncated MeCP2 rescues Rett syndrome-like neurological defects ', Nature, vol. 550, pp. 398-401 . https://doi.org/10.1038/nature24058
Nature
Nature
Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett syndrome1. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine2, 3. Functiona
Autor:
Bee Ling Ng, Chad Whilding, Kevin K. Brown, Dounia Djeghloul, Abul K. Tarafder, Matthias Merkenschlager, Kohler A-C., James I. Elliott, Holger Kramer, N Veland, Andrew Dimond, Jacky Guy, Jan Löwe, Yike Guo, Amanda G. Fisher, Amelie Feytout, Bhavik Anil Patel, Bharat Tam.
Epigenetic information is transmitted from mother to daughter cells through mitosis. To identify trans-acting factors and cis-acting elements that might be important for conveying epigenetic memory through cell division, we isolated native (unfixed)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b156da0fd4a2968db49b1ccd77927d68
Autor:
Rebekah Tillotson, Dina De Sousa, Martha V. Koerner, Jacky Guy, Matthew J. Lyst, Mitchell A. Lazar, Jim Selfridge, Laura FitzPatrick, Alastair R.W. Kerr, Zheng Sun, Adrian Bird
Publikováno v:
Koerner, M V, Fitzpatrick, L, Selfridge, J, Guy, J, De Sousa, D, Tillotson, R, Kerr, A, Sun, Z, Lazar, M A, Lyst, M J & Bird, A 2018, ' Toxicity of overexpressed MeCP2 is independent of HDAC3 activity ', Genes & Development, vol. 32, no. 23-24, pp. 1514-1524 . https://doi.org/10.1101/gad.320325.118
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e9a5b5c6aff5436cc29cf6104de48
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
Autor:
Joussef Hayek, Claudio De Felice, Francesco Scalabrì, Silvia Leoncini, Antonietta Capone, Thierry Durand, Alessio Cortelazzo, Alessandra Pecorelli, Jacky Guy, Giuseppe Valacchi, Cinzia Della Giovampaola, Lello Zolla, Lucia Ciccoli, Roberto Guerranti, Cinzia Signorini, Cristiana Mirasole, Michele Madonna, Maurizio D'Esposito, Stefania Filosa
Publikováno v:
Neuroscience research
info:cnr-pdr/source/autori:Cortelazzo, Alessio; De Felice, Claudio; Guerranti, Roberto; Signorini, Cinzia; Leoncini, Silvia; Pecorelli, Alessandra; Scalabri, Francesco; Madonna, Michele; Filosa, Stefania; Della Giovampaola, Cinzia; Capone, Antonietta; Durand, Thierry; Mirasole, Cristiana; Zolla, Lello; Valacchi, Giuseppe; Ciccoli, Lucia; Guy, Jacky; D'Esposito, Maurizio; Hayek, Joussef/titolo:Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome/doi:10.1016%2Fj.neures.2015.10.002/rivista:Neuroscience research (Print)/anno:2016/pagina_da:28/pagina_a:34/intervallo_pagine:28–34/volume:105
info:cnr-pdr/source/autori:Cortelazzo, Alessio; De Felice, Claudio; Guerranti, Roberto; Signorini, Cinzia; Leoncini, Silvia; Pecorelli, Alessandra; Scalabri, Francesco; Madonna, Michele; Filosa, Stefania; Della Giovampaola, Cinzia; Capone, Antonietta; Durand, Thierry; Mirasole, Cristiana; Zolla, Lello; Valacchi, Giuseppe; Ciccoli, Lucia; Guy, Jacky; D'Esposito, Maurizio; Hayek, Joussef/titolo:Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome/doi:10.1016%2Fj.neures.2015.10.002/rivista:Neuroscience research (Print)/anno:2016/pagina_da:28/pagina_a:34/intervallo_pagine:28–34/volume:105
Neurological disorders can be associated with protein glycosylation abnormalities. Rett syndrome is a devastating genetic brain disorder, mainly caused by de novo loss-of-function mutations in the methylCpG binding protein 2 (MECP2) gene. Although it