Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jacky Chi-Ki Ngo"'
Autor:
Qian Zhang, Ho Tsoi, Shaohong Peng, Pan P. Li, Kwok-Fai Lau, Dobrila D. Rudnicki, Jacky Chi-Ki Ngo, Ho Yin Edwin Chan
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 321-334 (2016)
Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also the
Externí odkaz:
https://doaj.org/article/2c9810f11c6f4bf2b4437298fa3f9600
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Serine–arginine (SR) proteins are splicing factors that play essential roles in both constitutive and alternative pre-mRNA splicing. Phosphorylation of their C-terminal RS domains by SR protein kinases (SRPKs) regulates their localization
Externí odkaz:
https://doaj.org/article/e53373ed56454d088bb4b4724601b5c9
Autor:
Ryan Pak Hong Yip, Doris Ching Ying Kwok, Louis Tung Faat Lai, Siu-Ming Ho, Ivan Chun Kit Wong, Chi-Ping Chan, Wilson Chun Yu Lau, Jacky Chi Ki Ngo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011978 (2024)
Members of the serine-arginine protein kinase (SRPK) family, SRPK1 and SRPK2, phosphorylate the hepatitis B core protein (Cp) and are crucial for pregenomic RNA encapsidation during viral nucleocapsid assembly. Among them, SRPK2 exhibits higher kinas
Externí odkaz:
https://doaj.org/article/bbcce046117a45109a7b6089359813bc
Autor:
Qian Zhang, Ying An, Zhefan Stephen Chen, Alex Chun Koon, Kwok-Fai Lau, Jacky Chi Ki Ngo, Ho Yin Edwin Chan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 172-185 (2019)
One drug, two diseases is a rare and economical therapeutic strategy that is highly desirable in the pharmaceutical industry. We previously reported a 21-amino acid peptide named beta-structured inhibitor for neurodegenerative diseases (BIND) that ca
Externí odkaz:
https://doaj.org/article/93a3c017448d49dfb54ad5fc338c760b
Autor:
Qingyun Li, Chuyue Zeng, Haizhen Liu, Kristen Wing Yu Yung, Chun Chen, Qiuling Xie, Yu Zhang, Stephanie Winn Chee Wan, Bertha Sze Wing Mak, Jiang Xia, Sheng Xiong, Jacky Chi Ki Ngo
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102423- (2021)
Summary: Serine-arginine (SR) protein kinases (SRPKs) regulate the functions of the SR-rich splicing factors by phosphorylating multiple serines within their C-terminal arginine-serine-rich domains. Dysregulation of these phosphorylation events has b
Externí odkaz:
https://doaj.org/article/afa3e81a24ce425db651e30e9295dc91
Publikováno v:
Nucleic Acids Research. 50:7655-7668
Polyglutamine (polyQ) diseases are a type of inherited neurodegenerative disorders caused by cytosine–adenine–guanine (CAG) trinucleotide expansion within the coding region of the disease-associated genes. We previously demonstrated that a pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1144ee0420396be58ab6a10af59f72
https://doi.org/10.1093/nar/gkac532
https://doi.org/10.1093/nar/gkac532
Autor:
Yi Wang, Ming-Yan Cheung, Yitao Gou, Qi Jia, Jacky Chi Ki Ngo, Tianjie Li, Zhongzhou Chen, Hon-Ming Lam
Publikováno v:
Biochemical Journal. 477:3935-3949
The unconventional G-protein OsYchF1 plays regulatory roles in plant defense and abiotic stress responses. We have previously resolved the crystal structures of OsYchF1 and its plant-specific regulator, OsGAP1, and determined the residues on OsGAP1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e8de933702e06d1990a00a7776343
https://doi.org/10.1042/bcj20200380
https://doi.org/10.1042/bcj20200380
Autor:
Jacky Chi Ki Ngo, Alex Chun Koon, Ho Yu Au-Yeung, Huiling Hong, Ho Yin Edwin Chan, Zhefan Stephen Chen, Chun-Ho Wong, Wen Li, Matthew Ho Yan Lau, Yuming Wei, Ying An, Steven C. Zimmerman, Kwok-Fai Lau
Publikováno v:
Journal of Biological Chemistry. 294:2757-5526
Polyglutamine (polyQ) diseases are a group of dominantly inherited neurodegenerative disorders caused by the expansion of an unstable CAG repeat in the coding region of the affected genes. Hallmarks of polyQ diseases include the accumulation of misfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e319b129a27497e9ee63e3bf939daf
https://doi.org/10.1074/jbc.ra118.006307
https://doi.org/10.1074/jbc.ra118.006307
Autor:
Richard Y.T. Kao, Tinyi Chu, Jacky Chi Ki Ngo, Sheila Li, Carmen O. K. Law, Liang Zhang, Jeffrey Kwan-Yiu Lau, Terrence Chi-Kong Lau, Xing Weng, Hoa Quynh Pham, Hoi-Kuan Kong, Kwok-Fai Lau, Rui Wang
Publikováno v:
Journal of Biological Chemistry. 294:372-378
The ribosomal maturation factor P (RimP) is a highly conserved protein in bacteria and has been shown to be important in ribosomal assembly in Escherichia coli. Because of its central importance in bacterial metabolism, RimP represents a good potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a428f8031b32b1e7f947a3c02b44df19
https://doi.org/10.1074/jbc.ra118.002298
https://doi.org/10.1074/jbc.ra118.002298
Autor:
Kristen Wing Yu Yung, Gordon Ho Ching Chan, Terrence Chi-Kong Lau, Chuyue Zeng, Jacky Chi Ki Ngo, Yunxin Long, Carmen O. K. Law, Weng Hong Sou, Haizhen Liu, Stephanie Winn Chee Wan, Qingyun Li
Publikováno v:
Journal of Biological Chemistry. 294:1312-1327
Serine-arginine (SR) proteins are essential splicing factors containing a canonical RNA recognition motif (RRM), sometimes followed by a pseudo-RRM, and a C-terminal arginine/serine-rich (RS) domain that undergoes multisite phosphorylation. Phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461d25c10dce8a7f6e4a9ed9ed8e39aa
https://doi.org/10.1074/jbc.ra118.003392
https://doi.org/10.1074/jbc.ra118.003392