Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jacky B. Buckton"'
Autor:
Duncan S. Holmes, Ann Louise Walker, Katherine Louise Jones, Chris D. Edwards, Dramane I. Laine, Don O. Somers, Paul Bamborough, Smith Kathryn Jane, Shila Patel, Jacky B. Buckton, Suzanne J. deBoeck, Richard Martyn Angell, Penny A. Smee, Nicola Mary Aston, Stuart G. Cockerill
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96035dc37dc9d60b0821a85dd7535ae
https://pubmed.ncbi.nlm.nih.gov/18614366
https://pubmed.ncbi.nlm.nih.gov/18614366
Autor:
Richard Martyn Angell, David W. Brown, Katherine Louise Jones, Smith Kathryn Jane, Ann Louise Walker, Penny A. Smee, Tim Longstaff, Paul Bamborough, Tony D. Angell, Stuart G. Cockerill, Chris D. Edwards, Don O. Somers, Murray J. B. Brown, Jacky B. Buckton, Malcolm Willson
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(1)
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure–activity relationships of the series against p38α are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86feebad65214ffc6c268e00b3237bb0
https://pubmed.ncbi.nlm.nih.gov/17981461
https://pubmed.ncbi.nlm.nih.gov/17981461