Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jackson Michuda"'
Autor:
Elle C. Moore, Gerard C. Blobe, Nicholas C. DeVito, Brent A. Hanks, Michael R. Harrison, Christopher J. Hoimes, Jingquan Jia, Michael A. Morse, Parvathy Jayaprakasan, Andrew MacKelfresh, Hillary Mulder, Adam J. Hockenberry, Alia Zander, Martin C. Stumpe, Jackson Michuda, Kyle A. Beauchamp, Eric Perakslis, Timothy Taxter, Daniel J. George
Publikováno v:
Cancer Medicine, Vol 12, Iss 19, Pp 19394-19405 (2023)
Abstract Background Roughly 5% of metastatic cancers present with uncertain origin, for which molecular classification could influence subsequent management; however, prior studies of molecular diagnostic classifiers have reported mixed results with
Externí odkaz:
https://doaj.org/article/b59390dd42bb4274953a6323c81735b6
Autor:
Benjamin D. Leibowitz, Bonnie V. Dougherty, Joshua S. K. Bell, Joshuah Kapilivsky, Jackson Michuda, Andrew J. Sedgewick, Wesley A. Munson, Tushar A. Chandra, Jonathan R. Dry, Nike Beaubier, Catherine Igartua, Timothy Taxter
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following th
Externí odkaz:
https://doaj.org/article/dabd382b971d4f07ac2e0b21a3f9c4c3
Autor:
Jackson Michuda, Alessandra Breschi, Joshuah Kapilivsky, Kabir Manghnani, Calvin McCarter, Adam J. Hockenberry, Brittany Mineo, Catherine Igartua, Joel T. Dudley, Martin C. Stumpe, Nike Beaubier, Maryam Shirazi, Ryan Jones, Elizabeth Morency, Kim Blackwell, Justin Guinney, Kyle A. Beauchamp, Timothy Taxter
Publikováno v:
Molecular Diagnosis & Therapy.
Cancers assume a variety of distinct histologies and may originate from a myriad of sites including solid organs, hematopoietic cells, and connective tissue. Clinical decision making based on consensus guidelines such as NCCN is often predicated on a
Autor:
Benjamin Leibowitz, Bonnie V Dougherty, Joshua SK Bell, Joshuah Kapilivsky, Jackson Michuda, Andrew Sedgwick, Wesley Munson, Tushar Chandra, Jonathan R Dry, Nike Beaubier, Catherine Igartua, Timothy Taxter
BackgroundWith the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c713e85db2fb93206b659ff5c74ee93c
https://doi.org/10.1101/2021.12.20.21267985
https://doi.org/10.1101/2021.12.20.21267985
Autor:
Benjamin D. Leibowitz, Nike Beaubier, Jason Perera, Ariane Lozac’hmeur, Ameen A. Salahudeen, Aly A. Khan, Timothy Taxter, Kaanan P. Shah, Derick Hoskinson, Emily Kudalkar, Jackson Michuda, Jerod Parsons, Alexandria M. Bobe, Denise Lau, Stephen Bush, Robert Huether, Alan L. Chang, Wei Zhu, Robert Tell, Kevin P. White, Martin Bontrager, Catherine Igartua
Publikováno v:
Nature Biotechnology. 37:1351-1360
Genomic analysis of paired tumor–normal samples and clinical data can be used to match patients to cancer therapies or clinical trials. We analyzed 500 patient samples across diverse tumor types using the Tempus xT platform by DNA-seq, RNA-seq and
Autor:
Kaanan P. Shah, Jason Perera, Eric Lefkofsky, Jerod Parsons, Aly Khan, Denise Lau, Catherine Iguartua, Robert Tell, Timothy Taxter, Martin Bontrager, Shelly Sorrells, Kimberly Yeatts, Stephen Bush, Jackson Michuda, Nike Beaubier, Shelley M. MacNeil, Kevin P. White, Alan Chang, Timothy Baker, Brett Mahon, Robert Huether, Philip Ellis
Publikováno v:
Oncotarget
We developed and clinically validated a hybrid capture next generation sequencing assay to detect somatic alterations and microsatellite instability in solid tumors and hematologic malignancies. This targeted oncology assay utilizes tumor-normal matc
Autor:
Jackson Michuda, Ben Ho Park, Amy Lauren Cummings, Siddhartha Devarakonda, Bert O'Neil, Sumaiya Islam, Jerod Parsons, Rotem Ben-Shachar, Alessandra Breschi, Kimberly L. Blackwell, James Lin Chen, Joel Dudley, Martin Stumpe, Justin Guinney, Ezra E.W. Cohen
Publikováno v:
Journal of Clinical Oncology. 40:3077-3077
3077 Background: While targeted DNA-seq can detect clinically actionable fusions in tumor tissue samples, technical and analytical challenges may give rise to false negatives. RNA-based, whole-exome sequencing provides a complementary method for fusi
Autor:
Joshua S.K. Bell, Calvin McCarter, Catherine Igartua, Kevin P. White, Benjamin D. Leibowitz, Jackson Michuda
Publikováno v:
Cancer Research. 80:5481-5481
Transcriptome profiling of tumors by standard RNA-seq measures the average effect of the tumor microenvironment. This expression profile is largely shaped by the tumor architecture where tumor purity can directly influence the genomic interpretation
Autor:
Shlomit Amar-Farkash, Joshuah Kapilivsky, Benjamin D. Leibowitz, Kyle A. Beauchamp, Nike Beaubier, Jackson Michuda, Crystal Bevis, Kevin P. White, Timothy Taxter, Joshua S.K. Bell, Alessandra Breschi, Catherine Igartua, Martin C. Stumpe
Publikováno v:
Cancer Research. 80:5423-5423
Background: Tumors of unknown origin account for up to 5% of newly diagnosed cancers and the average survival time is 9 to 12 months from diagnosis. Establishing tumor type and subtype guides standard of care treatment for several NCCN targeted thera
Autor:
Joshua S.K. Bell, Calvin McCarter, Joshua Drews, Lee F. Langer, Wesley Munson, Saksham Saini, Benjamin D. Leibowitz, Jackson Michuda, Catherine Igartua, Kevin P. White
Publikováno v:
Cancer Research. 80:5466-5466
Laboratories conducting high volumes of RNA sequencing must be extremely wary of technical batch effects if samples are to be compared across extended time periods, which is imperative for the most well-powered analyses of cancer transcriptomes. Chan