Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jackson Lucinda Victoria"'
Autor:
Andrew Dalgleish, Keith R. Mulholland, Andrew D. Campbell, David Dave, Hannah Askey, Zhaoshan Cui, Gareth AstraZeneca R D Charnwood Ensor, Shenghua Wang, Peter R. Hamilton, Simone Tomasi, Mark A. Graham, Claire Heffernan, Lai Chan, Pengpeng Liu, Emma Randles, Martin F. Jones, Michael Popadynec, Dajiang Jing, Cooper Katie Grace, Mohammed Pervez, Maria Rita Galan Espinosa, Jackson Lucinda Victoria
Publikováno v:
Organic Process Research & Development. 25:43-56
Ceralasertib is currently being evaluated in multiple phase I/II clinical trials for the treatment of cancer. Its structure, comprising a pyrimidine core decorated with a chiral morpholine, a cyclo...
Autor:
Zhang Enxuan, Chris D. Parsons, David C. McKinney, Kevin William Leslie, Zhi-qing Liu, Miguel Gonzalez, Mark A. Graham, Jackson Lucinda Victoria, Rachel H. Munday, Jun-wang Zhang, Janette H. Cherryman, James Douglas, David Whittaker, Gary M. Noonan
Publikováno v:
Organic Process Research & Development. 25:57-67
New route development activities toward ceralasertib (AZD6738) have resulted in the discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic understanding resulting f...
Autor:
Bethany A. Jackson, Matthew Charles Evans, Gareth AstraZeneca R D Charnwood Ensor, Adam Clarke, Chris D. Parsons, Mairi M. Littleson, Mark Dow, Danny H. Legg, Thomas O. Ronson, Adam Herring, David J. Klauber, Štefan Moravčík, Rebecca E. Meadows, Andrew D. Campbell, Jackson Lucinda Victoria, Kevin William Leslie, Staffan Karlsson
Publikováno v:
Organic Process Research & Development. 23:1407-1419
The AstraZeneca approach to synthetic Route Design is exemplified through our AZD4635 chemical development program. The identification of possible new route concepts is presented, as well as their ...