Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jackson G. Egen"'
Autor:
Paul Noe, Joy H. Wang, Kyu Chung, Zhiyong Cheng, Jessica J. Field, Xiaomeng Shen, Stephanie C. Casey, Christa L. Cortesio, Cinthia V. Pastuskovas, Hyewon Phee, Kristin V. Tarbell, Jackson G. Egen, Amy-Jo Casbon
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/4f829c7b7a4d48b3bfb167162bd40337
Autor:
Paul Noe, Joy H. Wang, Kyu Chung, Zhiyong Cheng, Jessica J. Field, Xiaomeng Shen, Stephanie C. Casey, Christa L. Cortesio, Cinthia V. Pastuskovas, Hyewon Phee, Kristin V. Tarbell, Jackson G. Egen, Amy-Jo Casbon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Conventional type 1 dendritic cells (cDC1s) are superior in antigen cross-presentation and priming CD8+ T cell anti-tumor immunity and thus, are a target of high interest for cancer immunotherapy. Type I interferon (IFN) is a potent inducer of antige
Externí odkaz:
https://doaj.org/article/03541fea0c654008afc71aef6450c703
Autor:
Jennie C. Kim, Xian Liu, Karen Fitzgerald, Jason S. Eng, Jessica Orf, Sarah A. O’Brien, Brian Belmontes, Amy-Jo Casbon, Sergey V. Novitskiy, Kristin V. Tarbell, Jason DeVoss, Jackson G. Egen
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1327-1335
Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA sensing pathway is a critical upstream mediator of type I interferon product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c1085f9aa0140df9bbf9ebb6eac27d
https://doi.org/10.1007/s00262-022-03327-w
https://doi.org/10.1007/s00262-022-03327-w
Autor:
Tara Arvedson, Julie M. Bailis, Carolyn D. Britten, Matthias Klinger, Dirk Nagorsen, Angela Coxon, Jackson G. Egen, Flavius Martin
Publikováno v:
Annual Review of Cancer Biology. 6:17-34
T cell engagers (TCEs) are targeted immunotherapies that have emerged as a promising treatment to redirect effector T cells for tumor cell killing. The strong therapeutic value of TCEs, established by the approval of blinatumomab for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56250912f9054b6bf46ce2a8162b07ff
https://doi.org/10.1146/annurev-cancerbio-070620-104325
https://doi.org/10.1146/annurev-cancerbio-070620-104325
Publikováno v:
Immunity. 52:36-54
Therapeutics that target the T cell inhibitory checkpoint proteins CTLA-4 and PD(L)1 are efficacious across a broad range of cancers, resulting in reductions in tumor burden and increased long-term survival in subsets of patients. The significant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd730b2780bfda260c89e4da3ecf5ed
https://doi.org/10.1016/j.immuni.2019.12.010
https://doi.org/10.1016/j.immuni.2019.12.010
Autor:
Brian Belmontes, Rajkumar Noubade, Sarah A. O’Brien, Hayley Ma, Jason DeVoss, Benjamin M. Alba, Hong Tan, Jason Eng, Melissa Thomas, Kevin Cook, Deepali V. Sawant, Peng Li, Matthew Chun, Jackson G. Egen, Wendy Zhong, Anupurna Kaul, Famke Aeffner, Olivier Nolan-Stevaux, Xiaoting Wang, Markus Muenz
Publikováno v:
Science Translational Medicine. 13
Therapeutic approaches are needed to promote T cell-mediated destruction of poorly immunogenic, "cold" tumors typically associated with minimal response to immune checkpoint blockade (ICB) therapy. Bispecific T cell engager (BiTE) molecules induce re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3186549e7ccd8cfb6494764a71f7cab2
https://doi.org/10.1126/scitranslmed.abd1524
https://doi.org/10.1126/scitranslmed.abd1524
Autor:
Wenjun Ouyang, Andrew K. Sewell, Aeryon Kim, Xin Yu, Ian Driver, Jackson G. Egen, Zemin Zhang, Chia-Jung Han, Aleksandra Olow
Publikováno v:
The Journal of Immunology. 203:1076-1087
Elicitation of tumor cell killing by CD8+ T cells is an effective therapeutic approach for cancer. In addition to using immune checkpoint blockade to reinvigorate existing but unresponsive tumor-specific T cells, alternative therapeutic approaches ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b4e39cf041e37c8f557cd8172c34f3
https://doi.org/10.4049/jimmunol.1801472
https://doi.org/10.4049/jimmunol.1801472
Autor:
Steven E Kauder, Lydia Santell, Elaine Mai, Lilyan Y Wright, Elizabeth Luis, Elsa N N'Diaye, Jeff Lutman, Navneet Ratti, Susan M Sa, Henry R Maun, Eric Stefanich, Lino C Gonzalez, Robert R Graham, Lauri Diehl, William A Faubion, Mary E Keir, Judy Young, Amitabha Chaudhuri, Robert A Lazarus, Jackson G Egen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83958 (2013)
Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility t
Externí odkaz:
https://doaj.org/article/6b29382e11a343b58a0d4a762432fc8a
Autor:
Kristin V. Tarbell, Jackson G. Egen
Publikováno v:
Journal of Leukocyte Biology. 103:1117-1129
The generation and regulation of innate immune signals are key determinants of autoimmune pathogenesis. Emerging evidence suggests that parallel processes operating in the setting of solid tumors can similarly determine the balance between tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942395a0df8cb50ef5220aa927947ed
https://doi.org/10.1002/jlb.3mir1017-400r
https://doi.org/10.1002/jlb.3mir1017-400r
Publikováno v:
Methods. 127:45-52
Intra-vital two-photon microscopy (2P-IVM) allows for in-situ investigation of tissue organization, cell behavior and the dynamic interactions between different cell types in their natural environment. This methodology has also expanded our understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18cc46250f37451b3e7e79e729f0af5
https://doi.org/10.1016/j.ymeth.2017.04.012
https://doi.org/10.1016/j.ymeth.2017.04.012