Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jackson Burton"'
Autor:
Juan Francisco Morales, Marian Klose, Yannick Hoffert, Jagdeep T. Podichetty, Jackson Burton, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1309-1316 (2024)
Abstract Clinical trials seeking to delay or prevent the onset of type 1 diabetes (T1D) face a series of pragmatic challenges. Despite more than 100 years since the discovery of insulin, teplizumab remains the only FDA‐approved therapy to delay pro
Externí odkaz:
https://doaj.org/article/8b4ca31b57414e94973b9675f895a590
Autor:
Juan Francisco Morales, Rhoda Muse, Jagdeep T. Podichetty, Jackson Burton, Sarah David, Patrick Lang, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 1016-1028 (2023)
Abstract Clinical trials seeking type 1 diabetes prevention are challenging in terms of identifying patient populations likely to progress to type 1 diabetes within limited (i.e., short‐term) trial durations. Hence, we sought to improve such effort
Externí odkaz:
https://doaj.org/article/f29e4953b25f4d88b03fbbb1b32d2233
Autor:
George Roussos, Teresa Ruiz Herrero, Derek L. Hill, Ariel V. Dowling, Martijn L. T. M. Müller, Luc J. W. Evers, Jackson Burton, Adrian Derungs, Katherine Fisher, Krishna Praneeth Kilambi, Nitin Mehrotra, Roopal Bhatnagar, Sakshi Sardar, Diane Stephenson, Jamie L. Adams, E. Ray Dorsey, Josh Cosman
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-10 (2022)
Abstract Smartphones and wearables are widely recognised as the foundation for novel Digital Health Technologies (DHTs) for the clinical assessment of Parkinson’s disease. Yet, only limited progress has been made towards their regulatory acceptabil
Externí odkaz:
https://doaj.org/article/db03089d79b34210b7b6df5f8e088dd6
Autor:
Karthik Lingineni, Varun Aggarwal, Juan Francisco Morales, Daniela J. Conrado, Diane Corey, Camille Vong, Jackson Burton, Jane Larkindale, Klaus Romero, Stephan Schmidt, Sarah Kim, the Cooperative International Neuromuscular Research Group investigators and Duchenne Regulatory Science Consortium members
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 318-332 (2022)
Abstract Early clinical trials of therapies to treat Duchenne muscular dystrophy (DMD), a fatal genetic X‐linked pediatric disease, have been designed based on the limited understanding of natural disease progression and variability in clinical mea
Externí odkaz:
https://doaj.org/article/9a5c7e29fe9d4a999c3b88d80d68d01e
Autor:
Ariana P. Mullin, Diane Corey, Emily C. Turner, Richard Liwski, Daniel Olson, Jackson Burton, Sudhir Sivakumaran, Lynn D. Hudson, Klaus Romero, Diane T. Stephenson, Jane Larkindale
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 214-221 (2021)
Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history
Externí odkaz:
https://doaj.org/article/040f5d647bf1412f9332d9664f2c5e5e
Autor:
Diane Stephenson, Robert Alexander, Varun Aggarwal, Reham Badawy, Lisa Bain, Roopal Bhatnagar, Bastiaan R. Bloem, Babak Boroojerdi, Jackson Burton, Jesse M. Cedarbaum, Josh Cosman, David T. Dexter, Marissa Dockendorf, E. Ray Dorsey, Ariel V. Dowling, Luc J. W. Evers, Katherine Fisher, Mark Frasier, Luis Garcia-Gancedo, Jennifer C. Goldsack, Derek Hill, Janice Hitchcock, Michele T. Hu, Michael P. Lawton, Susan J. Lee, Michael Lindemann, Ken Marek, Nitin Mehrotra, Marjan J. Meinders, Michael Minchik, Lauren Oliva, Klaus Romero, George Roussos, Robert Rubens, Sakshi Sadar, Joseph Scheeren, Eiichi Sengoku, Tanya Simuni, Glenn Stebbins, Kirsten I. Taylor, Beatrice Yang, Neta Zach
Publikováno v:
Digital Biomarkers, Vol 4, Iss 1, Pp 28-49 (2020)
Innovative tools are urgently needed to accelerate the evaluation and subsequent approval of novel treatments that may slow, halt, or reverse the relentless progression of Parkinson disease (PD). Therapies that intervene early in the disease continuu
Externí odkaz:
https://doaj.org/article/02833b80db5e4df4916766e3401c1666
Autor:
Mohamed H. Shahin, Sanchita Bhattacharya, Diego Silva, Sarah Kim, Jackson Burton, Jagdeep Podichetty, Klaus Romero, Daniela J. Conrado
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 4, Pp 665-674 (2020)
Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated data sets can catalyze biomedical discoveries and drug development. Among the benefits are the fact that data sharing can help generate
Externí odkaz:
https://doaj.org/article/7a8c30b9e10b483fbfa7e66b200ec0a3
Autor:
Alan Talevi, Juan Francisco Morales, Gregory Hather, Jagdeep T. Podichetty, Sarah Kim, Peter C. Bloomingdale, Samuel Kim, Jackson Burton, Joshua D. Brown, Almut G. Winterstein, Stephan Schmidt, Jensen Kael White, Daniela J. Conrado
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 3, Pp 129-142 (2020)
Artificial intelligence, in particular machine learning (ML), has emerged as a key promising pillar to overcome the high failure rate in drug development. Here, we present a primer on the ML algorithms most commonly used in drug discovery and develop
Externí odkaz:
https://doaj.org/article/d5208d0836bd4fb5b198a9feaf57dd9b
Autor:
Kirsi M. Kinnunen, Ariana P. Mullin, Dorian Pustina, Emily C. Turner, Jackson Burton, Mark F. Gordon, Rachael I. Scahill, Emily C. Gantman, Simon Noble, Klaus Romero, Nellie Georgiou-Karistianis, Adam J. Schwarz
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Volumetric magnetic resonance imaging (vMRI) has been widely studied in Huntington's disease (HD) and is commonly used to assess treatment effects on brain atrophy in interventional trials. Global and regional trajectories of brain atrophy in HD, wit
Externí odkaz:
https://doaj.org/article/e0577540947f4cd59d387c0f62683aca
Autor:
Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc
Externí odkaz:
https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75