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Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.

Autor: Orr ST; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 10770 Science Center Drive, San Diego, California 92121, United States., Beveridge R; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Bhattacharya SK; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 610 Main St., Cambridge, Massachusetts 02139, United States., Cameron KO; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 610 Main St., Cambridge, Massachusetts 02139, United States., Coffey S; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Fernando D; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Hepworth D; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 610 Main St., Cambridge, Massachusetts 02139, United States., Jackson MV; Cardiovascular and Metabolic Research Unit, Pfizer Global Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Khot V; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Kosa R; Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Lapham K; Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Loria PM; Primary Pharmacology Group, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., McClure KF; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 610 Main St., Cambridge, Massachusetts 02139, United States., Patel J; Pharmaceutical Sciences, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Rose C; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 610 Main St., Cambridge, Massachusetts 02139, United States., Saenz J; Pharmaceutical Sciences, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Stock IA; Primary Pharmacology Group, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Storer G; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., von Volkenburg M; Cardiovascular and Metabolic Research Unit, Pfizer Global Research and Development , 610 Main Street, Cambridge, Massachusetts 02139, United States., Vrieze D; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Wang G; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Xiao J; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States., Zhang Y; Worldwide Medicinal Chemistry, Pfizer Global Research and Development , 550 Eastern Point Road, Groton, Connecticut 06340, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Dec 14; Vol. 6 (2), pp. 156-61. Date of Electronic Publication: 2014 Dec 14 (Print Publication: 2015).