Morphogen Delivery by Osteoconductive Nanoparticles Instructs Stromal Cell Spheroid Phenotype

Autor: J. Kent Leach, Jacklyn Whitehead, Alefia Kothambawala

Publikováno v: Advanced biosystems, vol 3, iss 12
Adv Biosyst

Mesenchymal stem/stromal cells (MSCs) exhibit a rapid loss in osteogenic phenotype upon removal of osteoinductive cues, as commonly occurs during transplantation. Osteogenic differentiation can be more effectively but not fully maintained by aggregat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b4dbff261dcebe83643f7baa8a4477
https://escholarship.org/uc/item/3nv4d6nn

Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids

Autor: J. Kent Leach, Katherine H. Griffin, Jacklyn Whitehead, Marissa Gionet-Gonzales, Charlotte E. Vorwald, Serena E. Cinque

Publikováno v: Biomaterials

Mesenchymal stromal cells (MSCs) can promote tissue repair in regenerative medicine, and their therapeutic potential is further enhanced via spheroid formation. Stress relaxation of hydrogels has emerged as a potent stimulus to enhance MSC spreading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3786bd5ec4d3695daa70f8cb3cea572c
https://doi.org/10.1016/j.biomaterials.2020.120607

High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels

Autor: J. Kent Leach, Charlotte E. Vorwald, Steve S. Ho, Jacklyn Whitehead

Publikováno v: Biomaterials for Tissue Engineering ISBN: 9781493977390

Mesenchymal stem cells (MSCs) are a promising cell source for tissue repair and regeneration due to their multilineage capacity, potential for autologous use, and secretion of potent bioactive factors to catalyze the endogenous repair program. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbdb4866d312db483a500108cdad602
https://pubmed.ncbi.nlm.nih.gov/29679328

Bioreactor culture duration of engineered constructs influences bone formation by mesenchymal stem cells

Autor: Jacklyn Whitehead, Osamu W. Yasui, J. Kent Leach, Debika Mitra

Perfusion culture of mesenchymal stem cells (MSCs) seeded in biomaterial scaffolds provides nutrients for cell survival, enhances extracellular matrix deposition, and increases osteogenic cell differentiation. However, there is no consensus on the ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca257c6b06f3a53b9040e21a79d7674
https://escholarship.org/uc/item/257433rz

Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation

Autor: Prue Talbot, Allison Ibarra, Jacklyn Whitehead, Nikki Jo-Hao Weng, Suzaynn F. Schick, Mohamad Sleiman, Vasundhra Bahl

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology, vol 150, iss 1
Bahl, V; Weng, NJ-H; Schick, SF; Sleiman, M; Whitehead, J; Ibarra, A; et al.(2016). Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. TOXICOLOGICAL SCIENCES, 150(1), 234-246. doi: 10.1093/toxsci/kfv327. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/4k69r4fr

Thirdhand smoke (THS) is a mixture of chemicals that remain on indoor surfaces after smoking has ceased. These chemicals can be inhaled, ingested, or absorbed dermally, and thus could impact human health. We evaluated the cytotoxicity and mode of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d407c96c25b46be12a0d6fba1b1910d
https://escholarship.org/uc/item/4k69r4fr