Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jackie Papkoff"'
Autor:
Linh Nguyen, Kiran Dhami, Jason Hudak, Ali Akin, Jun Ma, Peyman Akbari, Jackie Papkoff, Zuelay Rosario, Karin Ku
Publikováno v:
Cancer Research. 80:5566-5566
Recent evidence supports the role of gut commensal microbes in mediating patient response to immune checkpoint inhibitor therapies (ICT) and chemotherapy. Fecal transplants from ICT responder or non-responder patients into mice modulate syngeneic tum
Publikováno v:
Gastroenterology. 158:S-472
Autor:
Yang K. Chen, Daniel Langer, Joel S. Bentz, Jackie Papkoff, S. Russell Nash, Raj J. Shah, Wenhui Liu, Nida S. Awadallah, Kenneth R. Shroyer, Kathleen C. Torkko
Publikováno v:
Pancreas. 36:200-206
Objectives: This study compared p53 expression with B7-H4, a novel cancer biomarker, in pancreatic ductal adenocarcinoma (PDA) resection specimens and in a pilot series of endoscopic ultrasound-guided fine-needle aspirations (EUS-FNAs). Methods: B7-H
Autor:
Wenhui Liu, Sylvie Robine, Eunice Laurent, Roberto A. Macina, Guangjie Cheng, J. David Lambeth, Jackie Papkoff, James McCoy
Publikováno v:
International Journal of Cancer. 123:100-107
The NADPH-oxidase 1 (Nox1) is a homolog of gp91phox, the catalytic subunit of the phagocyte superoxide-generating NADPH-oxidase. Nox1 is expressed in normal colon epithelial cells and in colon tumor cell lines, and overexpression in model cells has b
Autor:
Donna L. Dehn, T. Miyatake, Barbara Tringler, Jackie Papkoff, Takayuki Enomoto, Ashanta Swisher, Shu-Hui Liu, Kathleen C. Torkko, Kenneth R. Shroyer, Wenhui Liu
Publikováno v:
Gynecologic Oncology. 106:119-127
Objectives and methods B7-H4 (DD-O110), a member of the B7 family, negatively regulates T cell-mediated immune response. Previous studies have shown that B7-H4 is highly expressed in endometrioid ovarian cancers with relatively low levels of expressi
Autor:
Jackie Papkoff
Publikováno v:
Expert Opinion on Therapeutic Targets. 11:585-588
Monoclonal antibodies are a rapidly growing class of drugs used for therapy of human cancers and other diseases. They can be used effectively to target tumor-specific molecules and thereby modulate key signaling pathways that play a role in tumor gro
Autor:
Wenhui Liu, Susan A. Davidson, Kenneth R. Shroyer, Laura Corral, Kathleen C. Torkko, M. Scott Lucia, Jackie Papkoff, Barbara Tringler, Takayuki Enomoto, David Heinz
Publikováno v:
Gynecologic Oncology. 100:44-52
Objectives. Despite great advances in therapeutic management, the mortality rate for ovarian cancer has remained relatively stable over the past 50 years. This study was designed to evaluate the expression of B7-H4 protein, recently identified as a p
Autor:
Wenhui Liu, Malavika Ghosh, Andrei Munteanu, Susana Salceda, Muriel Kmet, Roberto A. Macina, Tenny Tang, Jackie Papkoff, Glenn Pilkington
Publikováno v:
Experimental Cell Research. 306:128-141
B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. We independently identified B7-H4 (DD-O110) through a genomic effort to discover genes upregulated in tumors and here we
Publikováno v:
Cancer Research. 65:868-878
Human testisin, a serine protease, is highly expressed in ovarian cancer and premeiotic spermatocytes with relatively little expression in other normal tissues. We first showed that testisin was localized on the surface of cultured tumor cells as a g
Publikováno v:
Biochemical and Biophysical Research Communications. 301:84-91
Wnt glycoproteins are important regulators of cellular differentiation and embryonic development. Some Wnt proteins induce stabilization of beta-catenin which cooperatively regulates gene expression with LEF/Tcf transcription factors. Here we demonst