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Autor:
Justin C. Roth, G. Yancey Gillespie, Jackie N. Parker, James O. Peggins, Kathleen H. Price, Nicholas W. Powers, Jennifer M. Coleman, Steven L. Carroll, Richard J. Whitley, Sheila D. Grimes, James M. Markert, Kevin A. Cassady, Patricia E. Noker, James J. Cody
Publikováno v:
Human Gene Therapy Clinical Development. 25:16-27
Herpes simplex virus type 1 (HSV-1) mutants lacking the γ(1)34.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 to express immunostimulatory genes may potentiate therapeutic efficacy. We have previousl