Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jackie Linehan"'
Autor:
Eleni Demetriou, Mohamed Tachrount, Matthew Ellis, Jackie Linehan, Sebastian Brandner, John Collinge, Simon Mead, Karin Shmueli, Mark Farrow, Xavier Golay
Human prion diseases are fatal neurodegenerative disorders which cause cognitive impairment and neurological deficits. Additional measures of tissue status are necessary for improving the sensitivity and specificity of clinical diagnosis as in many c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a66ac839cc65dc548d20b6cced498be
https://doi.org/10.1101/2021.12.28.474373
https://doi.org/10.1101/2021.12.28.474373
Autor:
Graham S. Jackson, Jackie Linehan, Julie Ann Edgeworth, Anita Sicilia, Sebastian Brandner, John Collinge
Publikováno v:
The Journal of General Virology
Prions are comprised principally of aggregates of a misfolded host protein and cause fatal transmissible neurodegenerative disorders of mammals, such as variant Creutzfeldt–Jakob disease in humans and bovine spongiform encephalopathy in cattle. Pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a10c75473b9623c5a6e240fb6fb7ba5
https://doi.org/10.1099/vir.0.027201-0
https://doi.org/10.1099/vir.0.027201-0
Autor:
Heike Naumann, Jackie Linehan, Fiona Kerr, Naushaba Nayeem, Simon Lovestone, Sebastian Brandner
Publikováno v:
Molecular and Cellular Neuroscience. 34:400-408
Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de579c72f0b03da52b7ef96360311636
https://doi.org/10.1016/j.mcn.2006.11.014
https://doi.org/10.1016/j.mcn.2006.11.014
Autor:
Petra Hirsch, Edward McKintosh, Eckhard Flechsig, Charles Weissmann, Kanella Prodromidou, Jackie Linehan, Anthony R. Clarke, John Collinge, Graham S. Jackson, Sebastian Brandner
Publikováno v:
Journal of General Virology. 86:869-878
Prions, transmissible agents that cause Creutzfeldt-Jakob disease (CJD) and other prion diseases, are known to resist conventional sterilization procedures. Iatrogenic transmission of classical CJD via neurosurgical instruments is well documented and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c0407668823148554a272f08becd7
https://doi.org/10.1099/vir.0.80484-0
https://doi.org/10.1099/vir.0.80484-0
Autor:
John Collinge, Jackie Linehan, Elizabeth M. C. Fisher, Majid Hafezparast, Sebastian Brandner, Joanne E. Martin
Publikováno v:
Biochemical and Biophysical Research Communications. 326:18-22
A mechanism for transmission of the infectious prions from the peripheral nerve ends to the central nervous system is thought to involve neuronal anterograde and retrograde transport systems. Cytoplasmic dynein is the major retrograde transport molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a8c177e9962782d59b7001a23c11e0
https://doi.org/10.1016/j.bbrc.2004.10.206
https://doi.org/10.1016/j.bbrc.2004.10.206
Publikováno v:
Proceedings of the National Academy of Sciences. 101:3644-3649
The Doppel (Dpl) and Prion (PrP) proteins show 25% sequence identity and share several structural features with only minor differences. Dpl shows a PrP-like fold of its C-terminal globular domain and lacks the flexible N-terminal tail. The physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1349ab343fcefe3b38e8d1baa8f53f93
https://doi.org/10.1073/pnas.0308681101
https://doi.org/10.1073/pnas.0308681101
Case: Spinal cord compression arising from a failure to diagnose and treat a spinal epidural abscess
Autor:
QC Robin Oppenheim, QC Angus Moon, Kirsty Pike, Jane Lang, Ewan Lockhart, QC Martin Porter, Jackie Linehan, Matthew Trinder, Helen Staines
Publikováno v:
Clinical Risk. 16:192-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2d7a1e766dac4b240914c79909100c
https://doi.org/10.1258/cr.2010.10a016
https://doi.org/10.1258/cr.2010.10a016
Autor:
Sebastian Brandner, Nathalie Gros, Jackie Linehan, Graham S. Jackson, Susan Joiner, Julie Ann Edgeworth, Jonathan D. F. Wadsworth, Charles Weissmann, John Collinge, Jack Alden
Prions are transmissible agents that cause lethal neurodegeneration in humans and other mammals. Prions bind avidly to metal surfaces such as steel wires and, when surface-bound, can initiate infection of brain or cultured cells with remarkable effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee238356741c31ab7cf709cbfc607953
https://europepmc.org/articles/PMC2922516/
https://europepmc.org/articles/PMC2922516/
Autor:
Jackie Linehan, John Collinge, Sarah E. Lloyd, Marie O'Shea, Sebastian Brandner, Emma G. Maytham
The genetic basis of prion disease incubation time is principally determined by polymorphisms in the prion protein gene, Prnp. However, it is now known that other genetic factors are important. Several quantitative trait loci (QTL) have been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4f517ed58c358a8887fb836897ef47
https://europepmc.org/articles/PMC2535705/
https://europepmc.org/articles/PMC2535705/
Autor:
Victor L. J. Tybulewicz, Dean Nizetic, Claire Mulligan, Jackie Linehan, Janet Shipley, Afua Adjeiwaa Mensah, Beata Grygalewicz, Sebastian Brandner, Juergen Groet, Elizabeth M. C. Fisher, Sandra Ruf, Aideen O'Doherty
Publikováno v:
BMC Developmental Biology, Vol 7, Iss 1, p 131 (2007)
BMC Developmental Biology
BMC Developmental Biology
Background Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a number of neural pathologies including smaller brain size, redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6740291958c47740052800d1d6ea6d1
http://hdl.handle.net/10044/1/57996
http://hdl.handle.net/10044/1/57996