Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jackie L McCourt"'
Autor:
Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma
Externí odkaz:
https://doaj.org/article/b2cf4b0572df49f7aea7868e8825730a
Autor:
Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Cynthia Shu, Mohammad Hossein Afsharinia, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie
BackgroundThe dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3eae35cc0364e0e4d0f4446916199db
https://doi.org/10.1101/2022.07.26.501621
https://doi.org/10.1101/2022.07.26.501621
Autor:
Sivaraman Rajaganapathy, Murti V. Salapaka, Dawn A. Lowe, Preston M. McCourt, James M. Ervasti, Sayan Ghosal, Jackie L McCourt, Angus Lindsay
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Patients with Duchenne muscular dystrophy (DMD) lack the protein dystrophin, which is a critical molecular component of the dystrophin-glycoprotein complex (DGC). Dystrophin is hypothesized to function as a molecular shock absorber that mechanically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7faa69f6c5c788b2c6e051abd8c509b1
http://link.springer.com/article/10.1038/s41598-019-41569-4
http://link.springer.com/article/10.1038/s41598-019-41569-4
Autor:
Katherine G. Hammond, Elizabeth M. Gibbs, Kara M Shin, Jamie L. Marshall, Jackie L McCourt, Rachelle H. Crosbie
Publikováno v:
Hum Mol Genet
The dystrophin–glycoprotein complex (DGC) is a membrane adhesion complex that provides structural stability at the sarcolemma by linking the myocyte’s internal cytoskeleton and external extracellular matrix. In Duchenne muscular dystrophy (DMD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1651f2d41e93d82b0887ee001bb81060
https://europepmc.org/articles/PMC8091037/
https://europepmc.org/articles/PMC8091037/
Autor:
John T. Olthoff, Dawn A. Lowe, Jackie L McCourt, Robert W. Arpke, Dana M Talsness, James M. Ervasti, Michael Kyba, Joseph J. Belanto, Angus Lindsay, D'anna M. Nelson, Christopher M. Chamberlain, Paul D Chatterton, Preston M. McCourt
Publikováno v:
Human Molecular Genetics. 27:451-462
Missense mutations in the dystrophin protein can cause Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) through an undefined pathomechanism. In vitro studies suggest that missense mutations in the N-terminal actin-binding domain (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68a928c0f99288ccc316b5f315fa895
https://doi.org/10.1093/hmg/ddx414
https://doi.org/10.1093/hmg/ddx414
Autor:
Jackie L McCourt, Katrina K Rhett, Dana M Talsness, Michele A. Jaeger, Joseph J. Belanto, James M. Ervasti
Publikováno v:
Skeletal Muscle
Background The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating cooperative unfolding during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0a4eb48a1c93be29c6a619f693e4b4
http://europepmc.org/articles/PMC4424174
http://europepmc.org/articles/PMC4424174