Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jackie L Ludgate"'
Autor:
Benjamin J Halliday, Ryuji Fukuzawa, David M Markie, Richard G Grundy, Jackie L Ludgate, Michael A Black, Jane E Skeen, Robert J Weeks, Daniel R Catchpoole, Aedan G K Roberts, Anthony E Reeve, Ian M Morison
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007399 (2018)
Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline mutations, the characterisation of which has refined our understanding of nephrogenesis and carcinogenesis. Here we report that germline loss of function mut
Externí odkaz:
https://doaj.org/article/40aef522afc74369a20470895065cac4
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151341 (2016)
BACKGROUND:Childhood acute lymphoblastic leukaemia (ALL) is the most common malignancy in children. Despite high cure rates, side effects and late consequences of the intensive treatments are common. Unquestionably, the identification of new therapeu
Externí odkaz:
https://doaj.org/article/30f16ca82a1842dc8c33b65e3c9c6ea8
Autor:
Teena K. J. B. Gamage, William Schierding, Daniel Hurley, Peter Tsai, Jackie L. Ludgate, Chandrakanth Bhoothpur, Lawrence W. Chamley, Robert J. Weeks, Erin C. Macaulay, Joanna L. James
Publikováno v:
Epigenetics, Vol 13, Iss 12, Pp 1154-1173 (2018)
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function. Trophoblasts transform the maternal vasculature to allow efficient bl
Externí odkaz:
https://doaj.org/article/128c01ec68fe4a9784aedbd76ec11c86
A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA
Autor:
Jackie L. Ludgate, James Wright, Peter A. Stockwell, Ian M. Morison, Michael R. Eccles, Aniruddha Chatterjee
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinki
Externí odkaz:
https://doaj.org/article/876519d173b84f5693f060137b509ecb
Autor:
Teena K. J. B. Gamage, William Schierding, Peter Tsai, Jackie L. Ludgate, Lawrence W. Chamley, Robert J. Weeks, Erin C. Macaulay, Joanna L. James
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal growth in utero. DNA methylation is thought to impact placental development and function. Global DNA methylation studies using human placental lysates suggest th
Externí odkaz:
https://doaj.org/article/41831f45c781426aa9310e1ddef19c12
Publikováno v:
Journal of Clinical Immunology. 41:1943-1945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78557ec38dab442220db313816767d0c
https://doi.org/10.1007/s10875-021-01114-3
https://doi.org/10.1007/s10875-021-01114-3
Autor:
Gail Williams, Antony W. Braithwaite, Tania L. Slatter, Ian M. Morison, Robert J. Weeks, Jackie L. Ludgate, Sunali Mehta, Gwenn Le Mée, Rubina Khanal
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
The tumour suppressor gene, TES, is frequently methylated in many human tumours. Previously, we demonstrated that TES promoter methylation and transcriptional silencing was the most common molecular abnormality detected in childhood acute lymphoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792ec7cb53f3d148f3840472f21e5c92
https://doi.org/10.1038/s41598-020-73229-3
https://doi.org/10.1038/s41598-020-73229-3
Autor:
Robert J, Weeks, Jackie L, Ludgate, Gwenn, Le Mée, Rubina, Khanal, Sunali, Mehta, Gail, Williams, Tania L, Slatter, Antony W, Braithwaite, Ian M, Morison
Publikováno v:
Scientific reports. 10(1)
The tumour suppressor gene, TES, is frequently methylated in many human tumours. Previously, we demonstrated that TES promoter methylation and transcriptional silencing was the most common molecular abnormality detected in childhood acute lymphoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::399bbf83bed988f1e822021e2ee65353
https://pubmed.ncbi.nlm.nih.gov/33004921
https://pubmed.ncbi.nlm.nih.gov/33004921
A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA
Autor:
Aniruddha Chatterjee, Jackie L. Ludgate, James Wright, Ian M. Morison, Peter A. Stockwell, Michael R. Eccles
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-10 (2017)
BMC Medical Genomics
BMC Medical Genomics
Background Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinking. FFPE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a987411d0be60b0a9556ae14742d1c72
http://link.springer.com/article/10.1186/s12920-017-0290-1
http://link.springer.com/article/10.1186/s12920-017-0290-1
Autor:
Matthew Parry, Aniruddha Chatterjee, Erin C. Macaulay, Antonio Ahn, Jackie L. Ludgate, Ian M. Morison, Peter A. Stockwell, Michael R. Eccles, Tim Foster, Robert J. Weeks, Ingrid M. Knarston
Publikováno v:
Epigenomics. 9:823-832
Aim: Validation of sequencing-based DNA methylation data is an important step for meaningful translation of findings. However, there has been limited assessment of different platforms to validate methylation data from next generation sequencing. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf2f09d6145425c14a1dea156a92d07
https://doi.org/10.2217/epi-2016-0176
https://doi.org/10.2217/epi-2016-0176