Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jackie Hollinshead"'
Autor:
Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 465-474 (2018)
Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical diseases (NTDs) fasciolosis and schistosomiasis. Due to the absence o
Externí odkaz:
https://doaj.org/article/d7538bd8d6a54de3a201e4bbc39ca081
Autor:
Hamza Hameed, Elizabeth F. B. King, Katerina Doleckova, Barbara Bartholomew, Jackie Hollinshead, Haddijatou Mbye, Imran Ullah, Karen Walker, Maria Van Veelen, Somaia Saif Abou-Akkada, Robert J. Nash, Paul D. Horrocks, Helen P. Price
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 227 (2021)
The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her
Externí odkaz:
https://doaj.org/article/4b09ffa503f5486080fe5aeb4bd8ed4b
Autor:
Zahraa S. Al-Taie, Barbara Bartholomew, Simon J. Coles, Daniel M. Evans, Jackie Hollinshead, Leigh F. Jones, Rolf Kraehenbuehl, Patrick J. Murphy, Robert J. Nash, Yana B. Penkova, Graham J. Tizzard
Publikováno v:
Tetrahedron. 123:132959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ae8825247718ad47f611b3c884876d
https://doi.org/10.1016/j.tet.2022.132959
https://doi.org/10.1016/j.tet.2022.132959
Autor:
Maria Van Veelen, Imran Ullah, Robert J. Nash, Somaia Saif Abou-Akkada, Haddijatou Mbye, Karen Walker, Elizabeth F. B. King, Katerina Doleckova, Helen P. Price, Barbara Bartholomew, Hamza Hameed, Jackie Hollinshead, Paul Horrocks
Publikováno v:
Pharmaceuticals
Volume 14
Issue 3
Pharmaceuticals, Vol 14, Iss 227, p 227 (2021)
Volume 14
Issue 3
Pharmaceuticals, Vol 14, Iss 227, p 227 (2021)
The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8244b57068c41f1c56bd6a270d879d
http://europepmc.org/articles/PMC7998250
http://europepmc.org/articles/PMC7998250
Autor:
Hazel Sharp, Patrick J. Murphy, Jackie Hollinshead, Victoria A. Evans, Daniel M. Evans, Fabian Mitschang, Matthew L. Buck, Jack Wenbourne, Robert J. Nash, Dominik Herkt
Publikováno v:
Tetrahedron. 73:4545-4548
Tiruchanduramine 1 was prepared using a convergent strategy with the longest linear sequence being eight steps. Synthetic 1, displayed a broader range of inhibition than reported previously and, in addition to α-glucosidases, 1 also inhibits almond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f589aeea9a1e39486cd30f034d3d178
https://doi.org/10.1016/j.tet.2017.06.008
https://doi.org/10.1016/j.tet.2017.06.008
Autor:
Barbara Bartholomew, Iestyn Jones, Patrick J. Murphy, Robert J. Nash, Graham J. Tizzard, Andrew J. Thornhill, Simon J. Coles, Daniel M. Evans, Richard Rowles, Marcel Arndt, Yones K. Sadaghiani, Jackie Hollinshead, Vera Leitmann, Zainab Al Shuhaib, Mark Dennis, Dion Roberts
Publikováno v:
Tetrahedron. 73:845-852
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35785273feb841235acb95104e1a09cb
https://doi.org/10.1016/j.tet.2016.12.065
https://doi.org/10.1016/j.tet.2016.12.065
Autor:
George W. J. Fleet, Mark R. Wormald, Sarah F. Jenkinson, Atsushi Kato, R. Fernando Martínez, Jackie Hollinshead, Robert J. Nash, Shinpei Nakagawa
DMDP acetic acid [N-carboxymethyl-2,5-dideoxy-2,5-imino-D-mannitol] 5 from Stevia rebaudiana is the first isolated natural amino acid derived from iminosugars bearing an N-alkyl acid side chain; it is clear from GCMS studies that such derivatives wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d97011ec57c3676957589540d3e807
https://doi.org/10.1007/s00726-019-02730-5
https://doi.org/10.1007/s00726-019-02730-5
Autor:
Mark Dennis, Richard Rowles, Iestyn Jones, Deiniol Davies, Paul Hancock, Kristina Kähm, Patrick J. Murphy, Robert J. Nash, Matthew D. Fletcher, Daniel M. Evans, Jackie Hollinshead, Zainab Al Shuhaib, Herjan Franken, David M Potter
Publikováno v:
Tetrahedron. 70:4412-4419
The cyclisation of mono-protected and bis-protected guanidines 8a–j under standard iodocyclisation conditions (I2/K2CO3) gave the guanidine heterocycles 9–25 via either a direct cyclisation or by a cyclisation/ring-contraction process, which coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de813cb7a9ebe40ae59d436c22fb058d
https://doi.org/10.1016/j.tet.2014.03.087
https://doi.org/10.1016/j.tet.2014.03.087
Autor:
Sarah F. Jenkinson, Zoltan A. Gal, Amber L. Thompson, Jackie Hollinshead, George W. J. Fleet, Laurence Edmund Jones, Robert J. Nash, David J. Watkin
The absolute and relative configurations of 1-epialexine are established by X-ray crystallographic analysis, giving (1S,2R,3R,7S,7aS)-1,2,7-trihydroxy-3-(hydroxymethyl)pyrrolizidine. The compound crystallizes as the hemihydrate C(8)H(15)NO(4) x 0.5H(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f5bbd3d4b16e9ad8484fa299351eb2
https://doi.org/10.1107/s0108270108037086
https://doi.org/10.1107/s0108270108037086
[reaction: see text] A flexible route to polyhydroxylated pyrrolizidine alkaloids is described, starting from commercially available N-Boc pyrrole and using a partial reduction as the key step. Tactics for varying the stereochemistry around the ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a500307a9605cb8537c9d9c6646e50
https://ora.ox.ac.uk/objects/uuid:5e0b784a-2ffd-48ef-a004-430cc77d8e68
https://ora.ox.ac.uk/objects/uuid:5e0b784a-2ffd-48ef-a004-430cc77d8e68