Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jackie Eudaly"'
Autor:
Phil Ruiz, Gary S. Gilkeson, Mara Lennard Richard, Jennifer L. Scott, Jackie Eudaly, Melissa A. Cunningham, Jena R. Wirth
Publikováno v:
Journal of Autoimmunity. 97:59-69
Female sex is a risk factor for lupus. Sex hormones, sex chromosomes and hormone receptors are implicated in the pathogenic pathways in lupus. Estrogen receptor alpha (ERα) knockout (KO) mice are used for defining hormone receptor effects in lupus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b505fbc17144940ca69bd3265c259923
https://doi.org/10.1016/j.jaut.2018.10.011
https://doi.org/10.1016/j.jaut.2018.10.011
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d57e1aae12218d59519fcc7526af6f42
https://doi.org/10.1530/endoabs.54.p4
https://doi.org/10.1530/endoabs.54.p4
Autor:
Jackie Eudaly, Gary S. Gilkeson, Osama Naga, Jennifer L. Scott, Melissa A. Cunningham, Jena R. Wirth
Publikováno v:
The Journal of Immunology. 195:5561-5571
Female lupus-prone NZM2410 estrogen receptor α (ERα)–deficient mice are protected from renal disease and have prolonged survival compared with wild-type littermates; however, the mechanism of protection is unknown. Plasmacytoid dendritic cells (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4409ca204c13c5100d8b573020fda711
https://doi.org/10.4049/jimmunol.1500315
https://doi.org/10.4049/jimmunol.1500315
Publikováno v:
Clinical immunology (Orlando, Fla.). 183
Systemic lupus erythematosus (SLE) is a chronic and potentially severe autoimmune disease that disproportionately affects women. Despite a known role for hormonal factors impacting autoimmunity and disease pathogenesis, the specific mechanisms of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57505d72b6daefe67d16c943b69bf58
https://pubmed.ncbi.nlm.nih.gov/28822833
https://pubmed.ncbi.nlm.nih.gov/28822833
Plasmacytoid dendritic cells (pDCs) and their production of type I interferons (IFN) are key pathogenic mediators of systemic lupus erythematosus (SLE). Despite the key role of pDCs in SLE, the mechanism by which pDCs promote disease is not well unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294fa270fcdd5031f3c846992d8968c7
https://europepmc.org/articles/PMC7055466/
https://europepmc.org/articles/PMC7055466/
Publikováno v:
Rheumatology International. 33:2677-2681
Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d52800a248a51321ce90fd3875b9373
https://doi.org/10.1007/s00296-012-2493-2
https://doi.org/10.1007/s00296-012-2493-2
Publikováno v:
Clinical Immunology. 144:1-12
Systemic lupus erythematosus (SLE) is a disease that disproportionately affects females. Despite significant research effort, the mechanisms underlying the female predominance in this disease are largely unknown. Previously, we showed that estrogen r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aa2df6caad3e596740b1ffd0e969fd
https://doi.org/10.1016/j.clim.2012.04.001
https://doi.org/10.1016/j.clim.2012.04.001
Autor:
Jackie Eudaly, Subhajit Dasgupta
Publikováno v:
Results in Immunology. 2:196-203
TLR2 agonists are well known for inducing NF-kB activation and inflammation, while estrogen receptor-alpha (ER-α) is a regulator of estrogen-mediated anti-inflammatory responses. In the present work, we determined the role of ER-α and phosphorylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7129bf9efac4534a8e2ff1d2ecbfbce
Publikováno v:
Clinical Immunology. 128:259-268
Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca300ee5b209106b603cdc840cb89f65
https://doi.org/10.1016/j.clim.2008.03.508
https://doi.org/10.1016/j.clim.2008.03.508
Autor:
Matthew J. Jenny, Jackie Eudaly, Margie M. Peden-Adams, D. Alan Warren, Deborah E. Keil, Joshua Smythe
Publikováno v:
Toxicological Sciences. 76:347-356
Immunological parameters, host resistance, and thyroid hormones were evaluated in F 1 mice exposed in utero to jet propulsion fuel-8 (JP-8). C57BL/6 pregnant dams (mated with C3H/HeJ males) were gavaged daily on gestation days 6-15 with JP-8 in a veh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d6568444348bbb16a3d1461bb99c47
https://doi.org/10.1093/toxsci/kfg244
https://doi.org/10.1093/toxsci/kfg244