Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jackie E. Mordaunt"'
Autor:
Zhi-Jie Ni, Qun Li, Martin John Slater, Wuxin Zou, Linos Lazarides, Yang Liu, Lois L. Wright, Paul Rowland, Liang Liao, Charles Z. Ding, Tadeusz Skarzynski, Jacob J. Plattner, Jackie E. Mordaunt, Don O. Somers, Xianfeng Li, Colin M. Edge, Yong-Kang Zhang, Gemma Victoria White, Malcolm Ellis, Jon Wright, Stephen J. Baker, Dazhong Fan, Wieslaw M. Kazmierski, Gary K. Smith, Pia Thommes, Lewis E. Pennicott, Julia A. Hubbard, Richard L. Jarvest, Bill McDowell, Yasheen Zhou, Xuelei Qian, Pamela Nassau, Richard Martin Grimes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3550-3556
We have designed and synthesized a novel series of alpha-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b19b36f802cbd917e005f688fe4d445
https://doi.org/10.1016/j.bmcl.2010.04.129
https://doi.org/10.1016/j.bmcl.2010.04.129
Autor:
Fabrizio Nerozzi, Shalia S Shabbir, Paul G. Wyatt, Mamta Patel, Michael Allen, Josie Chilcott, Christopher J. Gardner, Marion J. Perren, Jackie E. Mordaunt, Livermore David, Gordon G. Weingarten, Ping Zhou, Patrick M. Woollard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1405-1411
The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1b65e9e762608b3da232e63c0d7e45
https://doi.org/10.1016/s0960-894x(02)00160-9
https://doi.org/10.1016/s0960-894x(02)00160-9
Autor:
Josie Chilcott, Paul Wyatt, Alison Foster, Jan Scicinski, Livermore David, Patrick M. Woollard, Michael J. Allen, Jackie E. Mordaunt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1399-1404
Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11967548f9f2b9d5d19dcd0b66893618
https://doi.org/10.1016/s0960-894x(02)00159-2
https://doi.org/10.1016/s0960-894x(02)00159-2
Autor:
Jackie E. Mordaunt, Paul Wyatt, Michael J. Allen, Alison Foster, Livermore David, Jan Scicinski, Josie Chilcott, Patrick M. Woollard
Publikováno v:
ChemInform. 33
Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::955cc0b1469ba5adf5d66c959e356c2a
https://doi.org/10.1002/chin.200236159
https://doi.org/10.1002/chin.200236159
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576686b5eeec8c0f48365eebac6acee4
https://doi.org/10.1002/chin.200236160
https://doi.org/10.1002/chin.200236160
Autor:
Matthew Campbell, Ping Zhou, Robert J. Young, Weston Helen Elisabeth, Savvas Kleanthous, David W. Brown, Champa Patel, Satish Dayal, Shah Gita Punjabhai, Alan D. Borthwick, N. Paul King, Cynthia L. Burns-Kurtis, Stefan Senger, Hawa Diallo, Máire A. Convery, Nigel S. Watson, Paul W. Smith, Henry Anderson Kelly, Miriam Crowe, Chuen Chan, Anthony J. Pateman, Jackie E. Mordaunt, Andrew M. Mason
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group with acyclic tertiary amide termini. Optimized hydrophobic cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3b9901e5afa05ffed0024b5adc2fb9
https://pubmed.ncbi.nlm.nih.gov/16982190
https://pubmed.ncbi.nlm.nih.gov/16982190