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Autor:
Manthena V.S. Varma, Ravi Visswanathan, David A. Tess, Caitlin Jagla, George Chang, JianHua Liu, Rhys M. Jones, Christopher Keefer, Li Di, John P. Umland, Nathaniel Johnson, Heather Eng, Michael J. Banker, R. Scott Obach, Keith Riccardi, Jillian Racich, Samantha Jordan, Anthony Carlo, Jonathan J. Novak, Jackie Carey, Julie Cianfrogna, Sarah Lazzaro
Publikováno v:
European Journal of Pharmaceutical Sciences. 155:105541
Human liver microsomes (HLM) and human hepatocytes (HHEP) are two common in vitro systems used in metabolic stability and inhibition studies. The comparison between the assays using the two systems can provide mechanistic insights on the interplay of