Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jacki M. Rorabaugh"'
Autor:
Darrick T. Balu, Harry Pantazopoulos, Cathy C.Y. Huang, Kevin Muszynski, Theresa Lynn Harvey, Yota Uno, Jacki M. Rorabaugh, Claire R. Galloway, Christian Botz-Zapp, Sabina Berretta, David Weinshenker, Joseph T. Coyle
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104511- (2019)
Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes indep
Externí odkaz:
https://doaj.org/article/1a5c97093b8940d89bd516ac40a6131c
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Degeneration of locus coeruleus (LC) is an underappreciated hallmark of Alzheimer’s disease (AD). The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-bet
Externí odkaz:
https://doaj.org/article/5abf8a1afaf2473e8c90131e54041429
Autor:
Michael A. Kelberman, Jacki M. Rorabaugh, Claire R. Anderson, Alexia Marriott, Seth D. DePuy, Kurt Rasmussen, Katharine E. McCann, Jay M. Weiss, David Weinshenker
Publikováno v:
Neurobiology of Aging. 125:98-108
Accumulation of hyperphosphorylated tau in the locus coeruleus (LC) is a ubiquitous feature of prodromal Alzheimer’s disease (AD), and LC neurons degenerate as AD progresses. Tau-mediated LC dysfunction may contribute to early neuropsychiatric symp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424dfa04835fd809a208b1fc9f5d73a1
https://doi.org/10.1016/j.neurobiolaging.2023.01.016
https://doi.org/10.1016/j.neurobiolaging.2023.01.016
Autor:
Michael Kelberman, Eli Chlan, Claire R. Anderson, Jacki M. Rorabaugh, David Weinshenker, Katharine E. McCann
BackgroundThe locus coeruleus (LC) is one of the earliest brain regions to accumulate hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has hampered our ability to understand its contributions to the pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::524d02556f2e4425e0de157135249046
https://doi.org/10.1101/2021.10.30.466530
https://doi.org/10.1101/2021.10.30.466530
Autor:
Theresa L. Harvey, Joseph T. Coyle, Kevin Muszynski, Claire R. Galloway, Harry Pantazopoulos, Cathy C.Y. Huang, Yota Uno, Christian A. Botz-Zapp, Sabina Berretta, Jacki M. Rorabaugh, David Weinshenker, Darrick T. Balu
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 130, Iss, Pp 104511-(2019)
Neurobiology of Disease, Vol 130, Iss, Pp 104511-(2019)
Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858b5bff250d09a080bcb33c7a6148da
https://europepmc.org/articles/PMC6689433/
https://europepmc.org/articles/PMC6689433/
Autor:
David Weinshenker, Allan I. Levey, Seth D. DePuy, James J. Lah, Jacki M. Rorabaugh, Termpanit Chalermpalanupap, Kurt Rasmussen, Robert M. Cohen
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8dfa2b47bea679ccfab1ea7d3cf6f1
https://doi.org/10.1016/j.jalz.2018.06.2891
https://doi.org/10.1016/j.jalz.2018.06.2891
Autor:
David Weinshenker, Allan I. Levey, James J. Lah, Jacki M. Rorabaugh, Jason P. Schroeder, L. Cameron Liles, Termpanit Chalermpalanupap
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(1)
The brainstem locus coeruleus (LC) supplies norepinephrine to the forebrain and degenerates in Alzheimer's disease (AD). Loss of LC neurons is correlated with increased severity of other AD hallmarks, including β-amyloid (Aβ) plaques, tau neurofibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62638204e32115d5ec5b3318037c736
https://pubmed.ncbi.nlm.nih.gov/29928191
https://pubmed.ncbi.nlm.nih.gov/29928191
Autor:
Robert M. Cohen, Termpanit Chalermpalanupap, Christian A. Botz-Zapp, Natalie A Lembeck, David Weinshenker, Vanessa M Fu, Jacki M. Rorabaugh
Publikováno v:
Brain : a journal of neurology. 140(11)
See Grinberg and Heinsen (doi:10.1093/brain/awx261) for a scientific commentary on this article. Clinical evidence suggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a critical early step in Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fe32096b9476873d9ed460bcb8df2d
https://pubmed.ncbi.nlm.nih.gov/29088348
https://pubmed.ncbi.nlm.nih.gov/29088348
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Neural Plasticity
Neural Plasticity
Degeneration of locus coeruleus (LC) is an underappreciated hallmark of Alzheimer’s disease (AD). The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9499c69feedb5247c77e701ab5b44a
https://doaj.org/article/5abf8a1afaf2473e8c90131e54041429
https://doaj.org/article/5abf8a1afaf2473e8c90131e54041429
Autor:
Bruce H. Mandt, Toni L. Richards, Gaynor A. Larson, Jacki M. Rorabaugh, Christopher M.C. Ng, Nancy R. Zahniser, Dorothy J. Yamamoto, Kelsey Barcomb, Richard M. Allen, Anna M. Nelson
Publikováno v:
Neuroscience & Biobehavioral Reviews. 37:1738-1753
Individual differences are a hallmark of drug addiction. Here, we describe a rat model based on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine levels, individual outbred Sprague-Dawley rats exhibit markedly dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9291dc2950d93efc8e2de7b5411e79c8
https://doi.org/10.1016/j.neubiorev.2013.07.002
https://doi.org/10.1016/j.neubiorev.2013.07.002