Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jack W Houghton"'
Autor:
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
Publikováno v:
eLife, Vol 9 (2020)
Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)−1 proteins pUL7 and pUL51 form a complex required for efficient virus envelopment. We show
Externí odkaz:
https://doaj.org/article/cfd82648c6a14487a1d5e6ed851657bb
Autor:
Chayachon Apiwat, Jack W. Houghton, Ren Ren, Edward Tate, Joshua B. Edel, Narong Chanlek, Patraporn Luksirikul, Deanpen Japrung
Publikováno v:
ACS Omega, Vol 9, Iss 39, Pp 40592-40607 (2024)
Externí odkaz:
https://doaj.org/article/4243bd359b9b4826894fb1b56ccb9986
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Orthodontic tooth movement (OTM) occurs through proteolytic remodelling within the periodontium following the application of external force to the tooth. This study describes the first characterization of the salivary peptidome and protease
Externí odkaz:
https://doaj.org/article/2eea2a06dbc5434787b26f4df32b0b0a
Autor:
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial
Externí odkaz:
https://doaj.org/article/368ff8225df849cf9afb4ff9c4c9c5e7
Autor:
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry
Externí odkaz:
https://doaj.org/article/fd64e47b9b4b4f72b97a7e62b277b2d8
Autor:
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly
HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3adbe43d1d79de2094f6b253d19fc9
Autor:
Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Sarah J. Horton, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J.P. Huntly
HOXA9is commonly upregulated in acute myeloid leukemia (AML), where it confers poor prognosis. Characterising the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachment prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a3d3b93e16667dece75d4af728e86c
https://doi.org/10.1101/2022.10.12.511919
https://doi.org/10.1101/2022.10.12.511919
Autor:
Andrew M. James, Abigail A.I. Norman, Jack W. Houghton, Hiran A. Prag, Angela Logan, Robin Antrobus, Richard C. Hartley, Michael P. Murphy
During metabolism, carboxylic acids are often activated by conjugation to the thiol of coenzyme A (CoA). The resulting acyl-CoAs comprise a group of ∼100 thioester-containing metabolites that could modify protein behavior through non-enzymatic N-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b911aa9580d8fe83e90a375365cc5c
https://www.repository.cam.ac.uk/handle/1810/336351
https://www.repository.cam.ac.uk/handle/1810/336351
Autor:
Edward Chung Yern Wang, Luis Nobre, Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Zerbe C, Nicolás M. Suárez, Jenna Nichols, Robin Antrobus, Andrew J. Davison, Jack W. Houghton, Leah M. Hunter, Michael P. Weekes, Richard J. Stanton, Ceri Alan Fielding, Blair L. Strang
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate and adaptive immunity. We have employed two novel, orthogonal multiplexed tandem mass tag-based proteomic screens to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb899ad069b60b78c6c6a6ccf4270619
https://www.repository.cam.ac.uk/handle/1810/331636
https://www.repository.cam.ac.uk/handle/1810/331636
Autor:
Michael P. Murphy, Alan J. Robinson, Ian M. Fearnley, Andrew M. James, Jack W. Houghton, Shujing Ding, Anthony C. Smith, Robin Antrobus
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Acyl-CoAs are reactive metabolites that can non-enzymatically S-acylate and N-acylate protein cysteine and lysine residues, respectively. N-acylation is irreversible and enhanced if a nearby cysteine residue undergoes an initial reversible S-acylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f09044d1d30b99d07f29d7d3291f9
https://www.repository.cam.ac.uk/handle/1810/316662
https://www.repository.cam.ac.uk/handle/1810/316662