Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Jack W, Singer"'
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222944 (2019)
Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling is critical to multiple cellular processes, including survival, differentiation, and proliferation. JAK-STAT signaling dysregulation has been noted in inflammatory d
Externí odkaz:
https://doaj.org/article/0a6c4642fce44293bfd6aac30fb1e078
Autor:
Srdan Verstovsek, Olatoyosi Odenike, Jack W. Singer, Tanya Granston, Suliman Al-Fayoumi, H. Joachim Deeg
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-12 (2016)
Abstract Background Pacritinib (SB1518) is a highly selective kinase inhibitor with specificity for JAK2, FLT3, IRAK1, and CFS1R. This multicenter phase 1/2 study evaluated the maximum tolerated dose (MTD), safety, and clinical activity of pacritinib
Externí odkaz:
https://doaj.org/article/0fdafc78409844928011088f7ac6b467
Autor:
Michael W. Deininger, Brian J. Druker, Junia V. Melo, Jack W. Singer, David Hollenback, Lynn Bonham, Peter de Vries, Nicolai Härtel, Shadmer Demehri, Taiping Jia, Paul La Rosée
Purpose: Lysophosphatidic acid acyltransferase (LPAAT)-β catalyzes the conversion of lysophosphatidic acid to phosphatidic acid, an essential component of several signaling pathways, including the Ras/mitogen-activated protein kinase pathway. Inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee49aa8ddce9e20ab10f9e83dfe9a19
https://doi.org/10.1158/1078-0432.c.6518575
https://doi.org/10.1158/1078-0432.c.6518575
Autor:
Michael W. Deininger, Brian J. Druker, Junia V. Melo, Jack W. Singer, David Hollenback, Lynn Bonham, Peter de Vries, Nicolai Härtel, Shadmer Demehri, Taiping Jia, Paul La Rosée
Supplementary Materials, Figures 1-4, Tables 1-2 from Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1723a7736fdf19c259754d3d2763f722
https://doi.org/10.1158/1078-0432.22441543.v1
https://doi.org/10.1158/1078-0432.22441543.v1
Autor:
Ryan A. Wilcox, Sami Malek, Megan S. Lim, Philip S. Boonstra, Jack W. Singer, Nathanael G. Bailey, Erlene Seymour, Tianjiao Wang, Ye Lu, Avery Polk
Generation of nurse-like cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7217adf7b8a0a2cde1342ab8bf6a0c6
https://doi.org/10.1158/1078-0432.22468323.v1
https://doi.org/10.1158/1078-0432.22468323.v1
Autor:
Ryan A. Wilcox, Sami Malek, Megan S. Lim, Philip S. Boonstra, Jack W. Singer, Nathanael G. Bailey, Erlene Seymour, Tianjiao Wang, Ye Lu, Avery Polk
Patient Characteristics (n=29)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34672646e5cebd8b8674f290844a2df
https://doi.org/10.1158/1078-0432.22468308
https://doi.org/10.1158/1078-0432.22468308
Autor:
Ryan A. Wilcox, Sami Malek, Megan S. Lim, Philip S. Boonstra, Jack W. Singer, Nathanael G. Bailey, Erlene Seymour, Tianjiao Wang, Ye Lu, Avery Polk
Generation of "nurse-like cells" in multiple myeloma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2368618df8cbc28e6b2cc970e48766b
https://doi.org/10.1158/1078-0432.22468311
https://doi.org/10.1158/1078-0432.22468311
Autor:
Ryan A. Wilcox, Sami Malek, Megan S. Lim, Philip S. Boonstra, Jack W. Singer, Nathanael G. Bailey, Erlene Seymour, Tianjiao Wang, Ye Lu, Avery Polk
Pacritinib impairs viability of established nurse-like cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c05aee9e55a059b408bf6cde9532130
https://doi.org/10.1158/1078-0432.22468314.v1
https://doi.org/10.1158/1078-0432.22468314.v1
Autor:
Ryan A. Wilcox, Sami Malek, Megan S. Lim, Philip S. Boonstra, Jack W. Singer, Nathanael G. Bailey, Erlene Seymour, Tianjiao Wang, Ye Lu, Avery Polk
Viable CLL cells may be identified by forward and side scatter characteristics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9457bcc941923cd23f37a6b2648dcfd2
https://doi.org/10.1158/1078-0432.22468320.v1
https://doi.org/10.1158/1078-0432.22468320.v1
Autor:
David Hollenback, Lynn Bonham, Laura Law, Eddie Rossnagle, Lisa Romero, Heather Carew, Christopher K. Tompkins, David W. Leung, Jack W. Singer, Thayer White
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 3, Pp 593-604 (2006)
Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the
Externí odkaz:
https://doaj.org/article/c9e298f004694354859270dc9a515b8e