Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jack Tuffin"'
Autor:
Jack Tuffin, Musleeha Chesor, Valeryia Kuzmuk, Tim Johnson, Simon C. Satchell, Gavin I. Welsh, Moin A. Saleem
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tuffin et al. demonstrate a method for culturing conditionally immortalized human podocytes and GEnCs in 3D by forming spheroid cultures termed GlomSpheres, which are found to segregate in an organized manner. These are shown to establish a GBM-like
Externí odkaz:
https://doaj.org/article/3454bab16428421b8cab931ece01a44c
Autor:
Musleeha Chesor, Jack Tuffin, Carl May, Irene Ghobrial, Melissa Little, Gavin Welsh, Moin Saleem
Recurrence of steroid-resistant nephrotic syndrome (SRNS) is thought to be due to an unknown “circulating factor”, the identity of which has so far remained elusive. Our previous work suggests a signaling role for protease-activated receptor-1 (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bec5cbf9af712e73c86c9a71a2b74f9b
https://doi.org/10.21203/rs.3.rs-1226619/v1
https://doi.org/10.21203/rs.3.rs-1226619/v1
Autor:
Musleeha Chesor, Gavin I. Welsh, Valeryia Kuzmuk, Tim Johnson, Jack Tuffin, Simon C. Satchell, Moin A. Saleem
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Tuffin, J, Chesor, M, Kuzmuk, V, Johnson, T, Satchell, S C, Welsh, G I & Saleem, M 2021, ' GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening ', Communications Biology, vol. 4, no. 1, 1351 . https://doi.org/10.1038/s42003-021-02868-7
Communications Biology
Tuffin, J, Chesor, M, Kuzmuk, V, Johnson, T, Satchell, S C, Welsh, G I & Saleem, M 2021, ' GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening ', Communications Biology, vol. 4, no. 1, 1351 . https://doi.org/10.1038/s42003-021-02868-7
The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease. Current two and three dimensional (2D and 3D) models that atte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55d34fce51c24becad76f58938dfa86
https://doi.org/10.1038/s42003-021-02868-7
https://doi.org/10.1038/s42003-021-02868-7
Autor:
Laura E. Swan, Kelly L. Budge, Gavin I. Welsh, Ioana-Roxana Martinas, Jack Tuffin, Rachael D. Wright, Thomas P. Wilm, Stephen J McWilliam, Louise Oni, James Littlewood
Publikováno v:
Clinical Kidney Journal
McWilliam, S, Wright, R, Welsh, G I, Tuffin, J, Budge, K, Swan, L, Will, T, Martinas, I-R, Littlewood, J & Oni, L 2020, ' The complex interplay between kidney injury and inflammation ', Clinical Kidney Journal . https://doi.org/10.1093/ckj/sfaa164
McWilliam, S, Wright, R, Welsh, G I, Tuffin, J, Budge, K, Swan, L, Will, T, Martinas, I-R, Littlewood, J & Oni, L 2020, ' The complex interplay between kidney injury and inflammation ', Clinical Kidney Journal . https://doi.org/10.1093/ckj/sfaa164
Acute kidney injury (AKI) has gained significant attention following patient safety alerts about the increased risk of harm to patients, including increased mortality and hospitalization. Common causes of AKI include hypovolaemia, nephrotoxic medicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff55ca2cf3a98fa56ce8637ad6fd9ed7
https://pubmed.ncbi.nlm.nih.gov/33777361
https://pubmed.ncbi.nlm.nih.gov/33777361
Autor:
Elisabeth L. Gill, Yan Yan Shery Huang, Francesco Simone Ruggeri, Iek Man Lei, Simon C. Satchell, Natasha S. Lewis, Tuomas P. J. Knowles, Jack Tuffin, Zhaoying Li, Luai Huleihel, Stephen F. Badylak, Gavin I. Welsh, Thierry Savin, Moin A. Saleem
Publikováno v:
Acta Biomaterialia, 78, 111-122
Acta Biomaterialia 78 (2018)
Li, Z, Tuffin, J, Lei, I M, Ruggeri, F S, Lewis, N S, Gill, E L, Savin, T, Huleihel, L, Badylak, S F, Knowles, T, Satchell, S, Welsh, G, Saleem, M & Shery Huang, Y Y 2018, ' Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes ', Acta Biomaterialia, vol. 78, pp. 111-122 . https://doi.org/10.1016/j.actbio.2018.08.010
Acta Biomaterialia
Acta Biomaterialia 78 (2018)
Li, Z, Tuffin, J, Lei, I M, Ruggeri, F S, Lewis, N S, Gill, E L, Savin, T, Huleihel, L, Badylak, S F, Knowles, T, Satchell, S, Welsh, G, Saleem, M & Shery Huang, Y Y 2018, ' Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes ', Acta Biomaterialia, vol. 78, pp. 111-122 . https://doi.org/10.1016/j.actbio.2018.08.010
Acta Biomaterialia
Recreating tissue-specific microenvironments of the extracellular matrix (ECM) in vitro is of broad interest for the fields of tissue engineering and organ-on-a-chip. Here, we present biofunctional ECM protein fibres and suspended membranes, with tun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84aeadcc6220ee8644e1a38917b4e8e
https://doi.org/10.1016/j.actbio.2018.08.010
https://doi.org/10.1016/j.actbio.2018.08.010
Autor:
Jack Tuffin, Tim Johnson, Adam W. Perriman, Simon C. Satchell, Thomas O. Richardson, Gavin I. Welsh, Moin A. Saleem, Madeline Burke
Publikováno v:
Tuffin, J, Burke, M, Richardson, T, Johnson, T, Saleem, M A, Satchell, S, Welsh, G I & Perriman, A 2019, ' A Composite Hydrogel Scaffold Permits Self-Organization and Matrix Deposition by Cocultured Human Glomerular Cells ', Advanced Healthcare Materials, vol. 8, no. 17, 1900698 . https://doi.org/10.1002/adhm.201900698
Tuffin, J, Burke, M, Richardson, T G, Johnson, T, Saleem, M, Satchell, S C, Welsh, G I & Perriman, A 2019, ' A Composite Hydrogel Scaffold Permits Self-Organization and Matrix Deposition by Cocultured Human Glomerular Cells ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201900698
Tuffin, J, Burke, M, Richardson, T G, Johnson, T, Saleem, M, Satchell, S C, Welsh, G I & Perriman, A 2019, ' A Composite Hydrogel Scaffold Permits Self-Organization and Matrix Deposition by Cocultured Human Glomerular Cells ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201900698
Three-dimensional scaffolds provide cells with a spatial environment that more closely resembles that of in vivo tissue, when compared to 2D culture on a plastic substrate. However, many scaffolding materials commonly used in tissue engineering tend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700ba0c3fb9fd31c4b8994efc85aa746
https://research-information.bris.ac.uk/ws/files/202417807/Merging_Result.pdf
https://research-information.bris.ac.uk/ws/files/202417807/Merging_Result.pdf
Autor:
Jack Tuffin, Elisabeth Darwent, Roma Rambaran, William L. Klein, Kirsti Gorringe, Kevin Staras, Violetta Soura, Arjuna Ratnayaka, Joe Atherton, Thomas L. Williams, Julian R. Thorpe, Maris Stewart-Parker, Pascale N. Lacor, Louise C. Serpell
Publikováno v:
Biochemical Journal. 441:579-590
Aβ42 [amyloid-β peptide-(1–42)] plays a central role in Alzheimer's disease and is known to have a detrimental effect on neuronal cell function and survival when assembled into an oligomeric form. In the present study we show that administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4bd20fb4e67619779ed69d42e1a4c3
https://doi.org/10.1042/bj20110749
https://doi.org/10.1042/bj20110749
Autor:
Adam W. Perriman, Simon C. Satchell, Moin A. Saleem, Tim Johnson, Jack Tuffin, Gavin I. Welsh, Madeline Burke
Publikováno v:
Nephrology Dialysis Transplantation. 30:iii395-iii396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7391123c21a3e1b21f4fdf460abb6545
https://doi.org/10.1093/ndt/gfv188.09
https://doi.org/10.1093/ndt/gfv188.09