PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

Autor: Melissa A. Burns, Pieter Van Vlierberghe, Lewis B. Silverman, Karen R. Rabin, Donna Neuberg, Kimberly Bodaar, Randi Isenhart, Salmaan Karim, Birgit Knoechel, Meenakshi Devidas, Stuart H. Orkin, Björn Menten, Alejandro Gutierrez, Triona Ni Chonghaile, James Degar, Kristen E. Stevenson, Ingrid M. Ariës, Kimberly P. Dunsmore, Sofie Peirs, Sebastian T. Balbach, Jack T Landrigan, Stephen E. Sallan, Mignon L. Loh, Laura Hinze, Anthony Letai, Maren Pfirrmann, Brent L. Wood, David T. Teachey, Stuart S. Winter, Stephen P. Hunger

Publikováno v: The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
The Journal of experimental medicine, vol 215, iss 12

Mitochondrial apoptotic priming predicts response to cancer chemotherapy, but the mechanisms underlying variability in this mitochondrial phenotype among closely related tumors are poorly understood. Ariës et al. show that PRC2 loss-of-function muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1008118d65ee601a642016f1a55a5
http://europepmc.org/articles/PMC6279404